FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167940772> ?p ?o ?g. }

• W2167940772 endingPage "498" @default.
• W2167940772 startingPage "491" @default.
• W2167940772 abstract "Antibodies that react with self-molecules occur in healthy individuals and are referred to as natural antibodies or autoantibodies. Natural autoantibodies are mainly IgM, are encoded by unmutated V(D)J genes and display a moderate affinity for self-antigens. They provide a first line of defense against infections, probably serve housekeeping functions and contribute to the homeostasis of the immune system. By contrast, high-affinity, somatically mutated IgG autoantibodies reflect a pathologic process whereby homeostatic pathways related to cell clearance, antigen-receptor signaling or cell effector functions are disturbed. In some autoimmune disorders, autoantibodies might be present before disease onset, show remarkable specificity and serve as biomarkers providing an opportunity for diagnosis and therapeutic intervention. In organ-specific autoimmune diseases, such as myasthenia gravis or pemphigus, autoantibodies directly bind to and injure target organs. In systemic autoimmune diseases, autoantibodies react with free molecules, such as phospholipids, as well as cell surface and nucleoprotein antigens, forming pathogenic antigen-antibody (immune) complexes. These autoantibodies injure tissues and organs through engagement of Fc gammaR activation of complement as well as internalization and activation of Toll-like receptors. Activation of intracellular Toll-like receptors in plasmacytoid dendritic cells leads to the production of type I interferon, whereas engagement of intracellular Toll-like receptors on antigen-presenting cells stimulates cell activation and the production of other inflammatory cytokines. Thus, immune complexes might perpetuate a positive feedback loop amplifying inflammatory responses." @default.
• W2167940772 created "2016-06-24" @default.
• W2167940772 creator A5005493295 @default.
• W2167940772 creator A5046159238 @default.
• W2167940772 date "2008-09-01" @default.
• W2167940772 modified "2023-10-11" @default.
• W2167940772 title "Nature and functions of autoantibodies" @default.
• W2167940772 cites W145446037 @default.
• W2167940772 cites W1513182594 @default.
• W2167940772 cites W1549704190 @default.
• W2167940772 cites W1590814315 @default.
• W2167940772 cites W1605213317 @default.
• W2167940772 cites W1891716036 @default.
• W2167940772 cites W1968677737 @default.
• W2167940772 cites W1969154794 @default.
• W2167940772 cites W1974032459 @default.
• W2167940772 cites W1976270460 @default.
• W2167940772 cites W1976399964 @default.
• W2167940772 cites W1981003679 @default.
• W2167940772 cites W1983263967 @default.
• W2167940772 cites W1988712438 @default.
• W2167940772 cites W1992707199 @default.
• W2167940772 cites W1994094364 @default.
• W2167940772 cites W2003790326 @default.
• W2167940772 cites W2004054985 @default.
• W2167940772 cites W2016333231 @default.
• W2167940772 cites W2018038239 @default.
• W2167940772 cites W2027102035 @default.
• W2167940772 cites W2034074912 @default.
• W2167940772 cites W2042797177 @default.
• W2167940772 cites W2046544896 @default.
• W2167940772 cites W2046957298 @default.
• W2167940772 cites W2055416932 @default.
• W2167940772 cites W2069359556 @default.
• W2167940772 cites W2070301660 @default.
• W2167940772 cites W2072261402 @default.
• W2167940772 cites W2075831717 @default.
• W2167940772 cites W2078610240 @default.
• W2167940772 cites W2078702080 @default.
• W2167940772 cites W2085382985 @default.
• W2167940772 cites W2085406842 @default.
• W2167940772 cites W2089900609 @default.
• W2167940772 cites W2091329672 @default.
• W2167940772 cites W2097556922 @default.
• W2167940772 cites W2110990893 @default.
• W2167940772 cites W2112157366 @default.
• W2167940772 cites W2116370657 @default.
• W2167940772 cites W2123412929 @default.
• W2167940772 cites W2125038143 @default.
• W2167940772 cites W2128904113 @default.
• W2167940772 cites W2129048672 @default.
• W2167940772 cites W2129375889 @default.
• W2167940772 cites W2134666735 @default.
• W2167940772 cites W2136960636 @default.
• W2167940772 cites W2155990088 @default.
• W2167940772 cites W2162532663 @default.
• W2167940772 cites W2166774900 @default.
• W2167940772 cites W2173075155 @default.
• W2167940772 cites W4238163997 @default.
• W2167940772 cites W4249053098 @default.
• W2167940772 doi "https://doi.org/10.1038/ncprheum0895" @default.
• W2167940772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2703183" @default.
• W2167940772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18756274" @default.
• W2167940772 hasPublicationYear "2008" @default.
• W2167940772 type Work @default.
• W2167940772 sameAs 2167940772 @default.
• W2167940772 citedByCount "278" @default.
• W2167940772 countsByYear W21679407722012 @default.
• W2167940772 countsByYear W21679407722013 @default.
• W2167940772 countsByYear W21679407722014 @default.
• W2167940772 countsByYear W21679407722015 @default.
• W2167940772 countsByYear W21679407722016 @default.
• W2167940772 countsByYear W21679407722017 @default.
• W2167940772 countsByYear W21679407722018 @default.
• W2167940772 countsByYear W21679407722019 @default.
• W2167940772 countsByYear W21679407722020 @default.
• W2167940772 countsByYear W21679407722021 @default.
• W2167940772 countsByYear W21679407722022 @default.
• W2167940772 countsByYear W21679407722023 @default.
• W2167940772 crossrefType "journal-article" @default.
• W2167940772 hasAuthorship W2167940772A5005493295 @default.
• W2167940772 hasAuthorship W2167940772A5046159238 @default.
• W2167940772 hasBestOaLocation W21679407722 @default.
• W2167940772 hasConcept C147483822 @default.
• W2167940772 hasConcept C159654299 @default.
• W2167940772 hasConcept C163764329 @default.
• W2167940772 hasConcept C170493617 @default.
• W2167940772 hasConcept C203014093 @default.
• W2167940772 hasConcept C55493867 @default.
• W2167940772 hasConcept C86803240 @default.
• W2167940772 hasConcept C8891405 @default.
• W2167940772 hasConcept C95444343 @default.
• W2167940772 hasConceptScore W2167940772C147483822 @default.
• W2167940772 hasConceptScore W2167940772C159654299 @default.
• W2167940772 hasConceptScore W2167940772C163764329 @default.
• W2167940772 hasConceptScore W2167940772C170493617 @default.
• W2167940772 hasConceptScore W2167940772C203014093 @default.
• W2167940772 hasConceptScore W2167940772C55493867 @default.

• next