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• W2167946160 abstract "To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum.Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages.The recombinant protein was produced successfully and a specific ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals varied minimally (147 ± 19 ng/mL). In contrast, 5 hepatitis C patients with cirrhosis showed much decreased sH2a levels (50 ± 9 ng/mL).Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential." @default.
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• W2167946160 date "2011-01-01" @default.
• W2167946160 modified "2023-10-16" @default.
• W2167946160 title "Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis" @default.
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• W2167946160 doi "https://doi.org/10.3748/wjg.v17.i48.5305" @default.
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