Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167977390> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2167977390 endingPage "2322" @default.
- W2167977390 startingPage "2312" @default.
- W2167977390 abstract "Abstract A sensitive and specific high‐performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the quantitative determination of gemcitabine (dFdC) and its metabolite 2′,2′‐difluorodeoxyuridine (dFdU) is presented. A 200‐µL aliquot of human plasma was spiked with a mixture of internal standards, didanosine, lamivudine and fludarabine, and extracted using solid‐phase extraction. Dried extracts were reconstituted in 1 mM ammonium acetate/acetonitrile (97:3, v/v) and 10‐µL volumes were injected onto the HPLC system. Separation was achieved on a 150 × 2.1 mm C18 bonded phase endcapped with polar groups (Synergi Hydro‐RP column) using an eluent composed of 1 mM ammonium acetate (pH 6.8)/acetonitrile (94:6, v/v). Detection was performed by positive ion electrospray ionization followed by MS/MS. The assay quantifies a range from 0.5 to 1000 ng/mL for gemcitabine and from 5 to 10 000 ng/mL for dFdU using 200 µL of human plasma sample. Validation results demonstrate that gemcitabine and dFdU concentrations can be accurately and precisely quantified in human plasma. This assay is used to support clinical pharmacologic studies with gemcitabine. Copyright © 2007 John Wiley & Sons, Ltd." @default.
- W2167977390 created "2016-06-24" @default.
- W2167977390 creator A5000418012 @default.
- W2167977390 creator A5041259777 @default.
- W2167977390 creator A5042446845 @default.
- W2167977390 creator A5056917101 @default.
- W2167977390 creator A5062227574 @default.
- W2167977390 date "2007-06-18" @default.
- W2167977390 modified "2023-10-17" @default.
- W2167977390 title "Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2′,2′-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry" @default.
- W2167977390 cites W1578231679 @default.
- W2167977390 cites W1890647543 @default.
- W2167977390 cites W1976487179 @default.
- W2167977390 cites W1977206788 @default.
- W2167977390 cites W1977515504 @default.
- W2167977390 cites W1987929588 @default.
- W2167977390 cites W2007640889 @default.
- W2167977390 cites W2012432138 @default.
- W2167977390 cites W2036064715 @default.
- W2167977390 cites W2037466436 @default.
- W2167977390 cites W2050226999 @default.
- W2167977390 cites W2050359740 @default.
- W2167977390 cites W2070381172 @default.
- W2167977390 cites W2083159715 @default.
- W2167977390 cites W2093004194 @default.
- W2167977390 cites W2102153151 @default.
- W2167977390 cites W2154587211 @default.
- W2167977390 cites W2155080317 @default.
- W2167977390 cites W2408127551 @default.
- W2167977390 doi "https://doi.org/10.1002/rcm.3096" @default.
- W2167977390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17577879" @default.
- W2167977390 hasPublicationYear "2007" @default.
- W2167977390 type Work @default.
- W2167977390 sameAs 2167977390 @default.
- W2167977390 citedByCount "36" @default.
- W2167977390 countsByYear W21679773902012 @default.
- W2167977390 countsByYear W21679773902013 @default.
- W2167977390 countsByYear W21679773902014 @default.
- W2167977390 countsByYear W21679773902015 @default.
- W2167977390 countsByYear W21679773902018 @default.
- W2167977390 countsByYear W21679773902019 @default.
- W2167977390 countsByYear W21679773902020 @default.
- W2167977390 countsByYear W21679773902021 @default.
- W2167977390 countsByYear W21679773902022 @default.
- W2167977390 countsByYear W21679773902023 @default.
- W2167977390 crossrefType "journal-article" @default.
- W2167977390 hasAuthorship W2167977390A5000418012 @default.
- W2167977390 hasAuthorship W2167977390A5041259777 @default.
- W2167977390 hasAuthorship W2167977390A5042446845 @default.
- W2167977390 hasAuthorship W2167977390A5056917101 @default.
- W2167977390 hasAuthorship W2167977390A5062227574 @default.
- W2167977390 hasConcept C162356407 @default.
- W2167977390 hasConcept C179998833 @default.
- W2167977390 hasConcept C185592680 @default.
- W2167977390 hasConcept C2777463227 @default.
- W2167977390 hasConcept C2777477808 @default.
- W2167977390 hasConcept C2780782300 @default.
- W2167977390 hasConcept C31827203 @default.
- W2167977390 hasConcept C40684141 @default.
- W2167977390 hasConcept C43617362 @default.
- W2167977390 hasConcept C4725764 @default.
- W2167977390 hasConcept C55493867 @default.
- W2167977390 hasConcept C64489805 @default.
- W2167977390 hasConcept C71043704 @default.
- W2167977390 hasConceptScore W2167977390C162356407 @default.
- W2167977390 hasConceptScore W2167977390C179998833 @default.
- W2167977390 hasConceptScore W2167977390C185592680 @default.
- W2167977390 hasConceptScore W2167977390C2777463227 @default.
- W2167977390 hasConceptScore W2167977390C2777477808 @default.
- W2167977390 hasConceptScore W2167977390C2780782300 @default.
- W2167977390 hasConceptScore W2167977390C31827203 @default.
- W2167977390 hasConceptScore W2167977390C40684141 @default.
- W2167977390 hasConceptScore W2167977390C43617362 @default.
- W2167977390 hasConceptScore W2167977390C4725764 @default.
- W2167977390 hasConceptScore W2167977390C55493867 @default.
- W2167977390 hasConceptScore W2167977390C64489805 @default.
- W2167977390 hasConceptScore W2167977390C71043704 @default.
- W2167977390 hasIssue "14" @default.
- W2167977390 hasLocation W21679773901 @default.
- W2167977390 hasLocation W21679773902 @default.
- W2167977390 hasOpenAccess W2167977390 @default.
- W2167977390 hasPrimaryLocation W21679773901 @default.
- W2167977390 hasRelatedWork W1988661674 @default.
- W2167977390 hasRelatedWork W1999397561 @default.
- W2167977390 hasRelatedWork W2000133861 @default.
- W2167977390 hasRelatedWork W2020902296 @default.
- W2167977390 hasRelatedWork W2044016383 @default.
- W2167977390 hasRelatedWork W2055798233 @default.
- W2167977390 hasRelatedWork W2091473231 @default.
- W2167977390 hasRelatedWork W2120155947 @default.
- W2167977390 hasRelatedWork W2151017812 @default.
- W2167977390 hasRelatedWork W964154261 @default.
- W2167977390 hasVolume "21" @default.
- W2167977390 isParatext "false" @default.
- W2167977390 isRetracted "false" @default.
- W2167977390 magId "2167977390" @default.
- W2167977390 workType "article" @default.