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- W2167992014 abstract "In previous reports we have shown that ginsenosides inhibit high threshold voltage-dependent channels in neuronal cells. However, these studies did not show whether ginsenosides-induced inhibition of currents discriminates among the various channel subtypes, although it is known that there are at least five different channel subtypes in neuronal cells. In this study we investigated the effect of ginsenosides on high threshold voltage-dependent channel subtypes using their selective channel blockers nimodipine (L-type), -conotoxin GVIA (N-type), or -agatoxin IVA (P-type) in bovine chromaffin cells. We could observe that ginsenosides inhibited high threshold voltage-dependent currents in a dose-dependent manner. The / was about 120 g/ml. Nimodipine had no effect on ginsenosides response. However, the effect of ginsenosides on currents was reduced by -conotoxin GVIA, -agatoxin IVA, and mixture of nimodipine, -contoxin GVIA, and -agatoxin IVA. These data suggest that ginsenosides are negatively coupled to three types of calcium channels in bovine chromaffin cell, including an -conotoxin GVIA-sensitive (N-type) channel, an -agatoxin IVA-sensitive (P-type) channel and nimodipine/-conotoxin GVIA/-agatoxin IVA-resistant (presumptive Q-type) channel.Q-type) channel." @default.
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- W2167992014 date "2000-03-01" @default.
- W2167992014 modified "2023-09-27" @default.
- W2167992014 title "Ginsenosides Inhibit N-, P-, and Q-types but not L-type of Ca2+ Channel in Bovine Chromaffin cells" @default.
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