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• W2167995517 endingPage "1831" @default.
• W2167995517 startingPage "1826" @default.
• W2167995517 abstract "Uterine ornithine decarboxylase (ODC) activity is reported to increase after estrogen administration to fetal, neonatal, immature, and adult rats, suggesting that it may be a useful marker in studies of the development of estrogen responsiveness. Standard conditions were validated for enzyme assay of uterine cytosols from 5-day-old rats, and it was demonstrated that full activity was retained after freezing cytosol in liquid N2. Maximal activity, obtained 6 h after the injection of 10 μgestradiol (E2) to 5-day-old rats, was also elicited by the same dose of mestranol, ethynylestradiol, diethylstilbestrol, or mox-estrol. Progesterone, testosterone, and low doses of the anties-trogens clomiphene and tamoxifen failed to alter background ODC levels, while high antiestrogen doses induced small increases in enzyme activity. The glucocorticoid prednisolone low-ered ODC activity. Dose-response curves established that E2 was more effective in increasing adult ODC levels (ED50 < 0.2 μg/kg E2) than neonatal ODC levels (ED50 = 2 μg/kg E2). Time-course measurements were conducted over 24 h in control and E2-injected animals on postnatal days 5, 10, 14, 20, and 28 and in 60-day-old ovariectomized adults. While an age-dependent de-crease in control and 6 h E2-induced ODC levels was observed,there was an unexpected progressive development by day 28 of a second peak of E2-induced ODC at 15-18 h. The 6 h neonatal and 6 and 15-18 h adult ODC peaks had apparent Km values for ornithine near 0.2 mM. The potential origin of the second peak and its relationship to other uterine events are discussed. (Endocrinology113: 1826, 1983)" @default.
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• W2167995517 date "1983-11-01" @default.
• W2167995517 modified "2023-09-27" @default.
• W2167995517 title "The Postnatal Ontogeny of Rat Uterine Ornithine Decarboxylase: Acquisition of a Second Peak of Estrogen-Induced Enzyme Activity" @default.
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• W2167995517 doi "https://doi.org/10.1210/endo-113-5-1826" @default.
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