FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167998990> ?p ?o ?g. }

• W2167998990 endingPage "2273" @default.
• W2167998990 startingPage "2263" @default.
• W2167998990 abstract "The flap endonuclease, FEN1, is an evolutionarily conserved component of DNA replication from archaebacteria to humans. Based on in vitro results, it processes Okazaki fragments during replication and is involved in base excision repair. FEN1 removes the last primer ribonucleotide on the lagging strand and it cleaves a 5' flap that may result from strand displacement during replication or during base excision repair. Its biological importance has been revealed largely through studies in the yeast Saccharomyces cerevisiae where deletion of the homologous gene RAD27 results in genome instability and mutagen sensitivity. While the in vivo function of Rad27 has been well characterized through genetic and biochemical approaches, little is understood about the in vivo functions of human FEN1. Guided by our recent results with yeast RAD27, we explored the function of human FEN1 in yeast. We found that the human FEN1 protein complements a yeast rad27 null mutant for a variety of defects including mutagen sensitivity, genetic instability and the synthetic lethal interactions of a rad27 rad51 and a rad27 pol3-01 mutant. Furthermore, a mutant form of FEN1 lacking nuclease function exhibits dominant-negative effects on cell growth and genome instability similar to those seen with the homologous yeast rad27 mutation. This genetic impact is stronger when the human and yeast PCNA-binding domains are exchanged. These data indicate that the human FEN1 and yeast Rad27 proteins act on the same substrate in vivo. Our study defines a sensitive yeast system for the identification and characterization of mutations in FEN1." @default.
• W2167998990 created "2016-06-24" @default.
• W2167998990 creator A5009256839 @default.
• W2167998990 creator A5040055257 @default.
• W2167998990 creator A5057522916 @default.
• W2167998990 creator A5070358742 @default.
• W2167998990 date "1999-11-01" @default.
• W2167998990 modified "2023-09-24" @default.
• W2167998990 title "Functional Analysis of Human FEN1 in Saccharomyces Cerevisiae and Its Role in Genome Stability" @default.
• W2167998990 cites W1506492200 @default.
• W2167998990 cites W1516514485 @default.
• W2167998990 cites W1546701310 @default.
• W2167998990 cites W1559808711 @default.
• W2167998990 cites W1604801834 @default.
• W2167998990 cites W1605120960 @default.
• W2167998990 cites W1856170453 @default.
• W2167998990 cites W1860417382 @default.
• W2167998990 cites W1922687004 @default.
• W2167998990 cites W1967209251 @default.
• W2167998990 cites W1974823582 @default.
• W2167998990 cites W1978955263 @default.
• W2167998990 cites W1981277651 @default.
• W2167998990 cites W1987115840 @default.
• W2167998990 cites W1988134858 @default.
• W2167998990 cites W1989026106 @default.
• W2167998990 cites W1993073412 @default.
• W2167998990 cites W1994084252 @default.
• W2167998990 cites W1999375826 @default.
• W2167998990 cites W2000965988 @default.
• W2167998990 cites W2011970141 @default.
• W2167998990 cites W2012306350 @default.
• W2167998990 cites W2013735712 @default.
• W2167998990 cites W2018078151 @default.
• W2167998990 cites W2019404529 @default.
• W2167998990 cites W2023476869 @default.
• W2167998990 cites W2026388436 @default.
• W2167998990 cites W2027998177 @default.
• W2167998990 cites W2028513756 @default.
• W2167998990 cites W2034535098 @default.
• W2167998990 cites W2036045863 @default.
• W2167998990 cites W2037987328 @default.
• W2167998990 cites W2038529419 @default.
• W2167998990 cites W2038599420 @default.
• W2167998990 cites W2039263836 @default.
• W2167998990 cites W2041929141 @default.
• W2167998990 cites W2049528447 @default.
• W2167998990 cites W2064477710 @default.
• W2167998990 cites W2067437719 @default.
• W2167998990 cites W2068388955 @default.
• W2167998990 cites W2069157381 @default.
• W2167998990 cites W2078424943 @default.
• W2167998990 cites W2081341310 @default.
• W2167998990 cites W2083843933 @default.
• W2167998990 cites W2088867782 @default.
• W2167998990 cites W2090110799 @default.
• W2167998990 cites W2090903262 @default.
• W2167998990 cites W2094292611 @default.
• W2167998990 cites W2097766570 @default.
• W2167998990 cites W2105311265 @default.
• W2167998990 cites W2106837356 @default.
• W2167998990 cites W2107856790 @default.
• W2167998990 cites W2112035003 @default.
• W2167998990 cites W2113320982 @default.
• W2167998990 cites W2115534366 @default.
• W2167998990 cites W2120179554 @default.
• W2167998990 cites W2121781767 @default.
• W2167998990 cites W2126938336 @default.
• W2167998990 cites W2133167492 @default.
• W2167998990 cites W2133231925 @default.
• W2167998990 cites W2136577955 @default.
• W2167998990 cites W2142485616 @default.
• W2167998990 cites W2146267178 @default.
• W2167998990 cites W2159531864 @default.
• W2167998990 cites W2161102962 @default.
• W2167998990 cites W2161588324 @default.
• W2167998990 cites W2161804304 @default.
• W2167998990 cites W2163827697 @default.
• W2167998990 cites W2167124397 @default.
• W2167998990 cites W2170294911 @default.
• W2167998990 cites W2183095402 @default.
• W2167998990 cites W4231457987 @default.
• W2167998990 cites W61650054 @default.
• W2167998990 doi "https://doi.org/10.1093/hmg/8.12.2263" @default.
• W2167998990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10545607" @default.
• W2167998990 hasPublicationYear "1999" @default.
• W2167998990 type Work @default.
• W2167998990 sameAs 2167998990 @default.
• W2167998990 citedByCount "38" @default.
• W2167998990 countsByYear W21679989902012 @default.
• W2167998990 countsByYear W21679989902014 @default.
• W2167998990 countsByYear W21679989902015 @default.
• W2167998990 countsByYear W21679989902020 @default.
• W2167998990 countsByYear W21679989902021 @default.
• W2167998990 countsByYear W21679989902022 @default.
• W2167998990 countsByYear W21679989902023 @default.
• W2167998990 crossrefType "journal-article" @default.
• W2167998990 hasAuthorship W2167998990A5009256839 @default.
• W2167998990 hasAuthorship W2167998990A5040055257 @default.

• next