FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168011390> ?p ?o ?g. }

• W2168011390 endingPage "214" @default.
• W2168011390 startingPage "207" @default.
• W2168011390 abstract "Perinatal Pb exposure may modulate arterial tone through nitric oxide (NO) and cyclooxygenase products. To investigate this, Wistar dams received 1000 ppm of Pb or sodium acetate (control) in drinking water during pregnancy and lactation. Curves were constructed in phenylephrine-precontracted intact and/or denuded rings of thoracic aortas of weaned (23-day-old) male pups from their responses to Nω-nitro-L-arginine methyl ester (L-NAME, NO synthase inhibitor) and ACh in the absence or presence of indomethacin (10−5M, cyclooxygenase inhibitor) or L-NAME (3 × 10−7M and 3 × 10−4M). Blood lead concentration and systolic blood pressure (SBP) were higher in intoxicated than control pups (blood lead μg/dl: control < 3.0, Pb 58.7 ± 6.5*; SBP mmHg: control 111.4 ± 2.3, Pb 135.5 ± 2.4*). In L-NAME–treated rings maximal responses increased in Pb-exposed rats, and were higher in intact than in denuded aortas (contraction [% of phenylephrine] intact: control 184.3 ± 23.7, Pb 289.1 ± 18.3*; denuded: control 125.1 ± 4.5, Pb 154.8 ± 13.3*). ACh-induced relaxation in intact aortas from Pb-exposed rats presented rightward shift in L-NAME presence (EC50 × 10−7M: control 1.32 [0.33–5.18], Pb 4.88 [3.56–6.69]*) but moved left under indomethacin (EC50 × 10−7M: control 8.95 [3.47–23.07], Pb 0.97 [0.38–2.43]*). *p < 0.05 significant relative to the respective control; N = 7–9. Endothelium removal abolished ACh-induced relaxation. Perinatal Pb exposure caused hypertension associated with alterations in the production and/or release of basal and stimulated endothelium-derived relaxing factors–NO and constricting cyclooxygenase products. These findings may help explain the contribution of NO and cyclooxygenase products to the etiology and/or maintenance of Pb-induced hypertension and could ultimately lead to therapeutic advantages in plumbism." @default.
• W2168011390 created "2016-06-24" @default.
• W2168011390 creator A5043467655 @default.
• W2168011390 creator A5049289413 @default.
• W2168011390 date "2008-01-30" @default.
• W2168011390 modified "2023-10-17" @default.
• W2168011390 title "Perinatal Lead Exposure Affects Nitric Oxide and Cyclooxygenase Pathways in Aorta of Weaned Rats" @default.
• W2168011390 cites W1966303951 @default.
• W2168011390 cites W1968037963 @default.
• W2168011390 cites W1972239750 @default.
• W2168011390 cites W1980172356 @default.
• W2168011390 cites W1988645515 @default.
• W2168011390 cites W1995490134 @default.
• W2168011390 cites W1996044976 @default.
• W2168011390 cites W2008467261 @default.
• W2168011390 cites W2008574207 @default.
• W2168011390 cites W2042602221 @default.
• W2168011390 cites W2043038271 @default.
• W2168011390 cites W2050920589 @default.
• W2168011390 cites W2055852663 @default.
• W2168011390 cites W2058860373 @default.
• W2168011390 cites W2060979954 @default.
• W2168011390 cites W2076598140 @default.
• W2168011390 cites W2077264422 @default.
• W2168011390 cites W2086487642 @default.
• W2168011390 cites W2088441373 @default.
• W2168011390 cites W2090073200 @default.
• W2168011390 cites W2090976877 @default.
• W2168011390 cites W2092516111 @default.
• W2168011390 cites W2102917615 @default.
• W2168011390 cites W2118571380 @default.
• W2168011390 cites W2162417004 @default.
• W2168011390 cites W2165131979 @default.
• W2168011390 cites W2329913746 @default.
• W2168011390 cites W2403921759 @default.
• W2168011390 doi "https://doi.org/10.1093/toxsci/kfn018" @default.
• W2168011390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18234738" @default.
• W2168011390 hasPublicationYear "2008" @default.
• W2168011390 type Work @default.
• W2168011390 sameAs 2168011390 @default.
• W2168011390 citedByCount "37" @default.
• W2168011390 countsByYear W21680113902012 @default.
• W2168011390 countsByYear W21680113902013 @default.
• W2168011390 countsByYear W21680113902014 @default.
• W2168011390 countsByYear W21680113902015 @default.
• W2168011390 countsByYear W21680113902016 @default.
• W2168011390 countsByYear W21680113902018 @default.
• W2168011390 countsByYear W21680113902019 @default.
• W2168011390 countsByYear W21680113902020 @default.
• W2168011390 countsByYear W21680113902021 @default.
• W2168011390 countsByYear W21680113902022 @default.
• W2168011390 countsByYear W21680113902023 @default.
• W2168011390 crossrefType "journal-article" @default.
• W2168011390 hasAuthorship W2168011390A5043467655 @default.
• W2168011390 hasAuthorship W2168011390A5049289413 @default.
• W2168011390 hasBestOaLocation W21680113901 @default.
• W2168011390 hasConcept C126322002 @default.
• W2168011390 hasConcept C134018914 @default.
• W2168011390 hasConcept C163415756 @default.
• W2168011390 hasConcept C181199279 @default.
• W2168011390 hasConcept C185592680 @default.
• W2168011390 hasConcept C2777622882 @default.
• W2168011390 hasConcept C2777663904 @default.
• W2168011390 hasConcept C2777952589 @default.
• W2168011390 hasConcept C2779689624 @default.
• W2168011390 hasConcept C2779961880 @default.
• W2168011390 hasConcept C2779980429 @default.
• W2168011390 hasConcept C519581460 @default.
• W2168011390 hasConcept C55493867 @default.
• W2168011390 hasConcept C71924100 @default.
• W2168011390 hasConcept C84393581 @default.
• W2168011390 hasConceptScore W2168011390C126322002 @default.
• W2168011390 hasConceptScore W2168011390C134018914 @default.
• W2168011390 hasConceptScore W2168011390C163415756 @default.
• W2168011390 hasConceptScore W2168011390C181199279 @default.
• W2168011390 hasConceptScore W2168011390C185592680 @default.
• W2168011390 hasConceptScore W2168011390C2777622882 @default.
• W2168011390 hasConceptScore W2168011390C2777663904 @default.
• W2168011390 hasConceptScore W2168011390C2777952589 @default.
• W2168011390 hasConceptScore W2168011390C2779689624 @default.
• W2168011390 hasConceptScore W2168011390C2779961880 @default.
• W2168011390 hasConceptScore W2168011390C2779980429 @default.
• W2168011390 hasConceptScore W2168011390C519581460 @default.
• W2168011390 hasConceptScore W2168011390C55493867 @default.
• W2168011390 hasConceptScore W2168011390C71924100 @default.
• W2168011390 hasConceptScore W2168011390C84393581 @default.
• W2168011390 hasIssue "1" @default.
• W2168011390 hasLocation W21680113901 @default.
• W2168011390 hasLocation W21680113902 @default.
• W2168011390 hasOpenAccess W2168011390 @default.
• W2168011390 hasPrimaryLocation W21680113901 @default.
• W2168011390 hasRelatedWork W2035949096 @default.
• W2168011390 hasRelatedWork W2044091624 @default.
• W2168011390 hasRelatedWork W2064969264 @default.
• W2168011390 hasRelatedWork W2080832935 @default.
• W2168011390 hasRelatedWork W2129759033 @default.
• W2168011390 hasRelatedWork W2313118354 @default.
• W2168011390 hasRelatedWork W2357536703 @default.

• next