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• W2168013372 abstract "Background: Endoscopic recurrence after surgery in Crohn9s disease is frequent and unpredictable. Abnormal intestinal production of pro- (interleukin (IL)-1β, tumour necrosis factor α (TNF-α)) and anti- (IL-10) inflammatory cytokines has been associated with severe outcome in experimental models of colitis. Patients and methods: We evaluated if ileal TNF-α, IL-1β, or IL-10 mRNA levels measured at the time of surgery predict endoscopic recurrence, and if ileal IL-10 levels are associated with particular IL-10 promoter alleles. Ileal biopsies were obtained peroperatively from the healthy neoileum of patients undergoing a right ileocolectomy for Crohn9s disease. Mucosal TNF-α, IL-1β, and IL-10 mRNA levels were quantified by competitive polymerase chain reaction. A cut off value was determined using a receiver operating curve. IL-10.G promoter haplotypes were analysed using a polymorphic dinucleotide repeat in the IL-10 promoter region. Results: Three months after surgery, 53% of patients had endoscopic recurrence while 47% remained free of disease. The risk of endoscopic recurrence correlated with ileal IL-10 mRNA concentrations (<i>r</i>²=0.81). Endoscopic recurrence occurred more frequently in patients classified as low IL-10 producers than in those that were high producers (80% <i>v</i> 40%) (p=0.02). Patients with at least one of the two alleles G7–8 or G10–13 produced, respectively, higher (p=0.006) and lower (p=0.029) ileal IL-10 mRNA. The distribution of IL-10.G microsatellite genotypes was similar in patients with or without endoscopic recurrence. Conclusion: Low ileal IL-10 mRNA concentration is a good marker of endoscopic recurrence in Crohn9s disease but the distribution of IL-10.G haplotypes cannot predict the postoperative evolution of the disease." @default.
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• W2168013372 date "2002-01-01" @default.
• W2168013372 modified "2023-10-16" @default.
• W2168013372 title "Low ileal interleukin 10 concentrations are predictive of endoscopic recurrence in patients with Crohn's disease" @default.
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• W2168013372 doi "https://doi.org/10.1136/gut.50.1.25" @default.
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