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• W2168019073 abstract "The chondroprotective success of meniscal transplantation is variable. Poorly controlled factors such as a geometrical mismatch of the implant may be partly responsible. Clinical data, animal studies and cadaver experiments suggest that smaller transplants perform better than oversized, but clear evidence is lacking. The hypothesis of this study is that smaller menisci outperform larger ones because they distribute stresses more effectively at those particular locations that receive the highest loads. Consequently, collagen in the adjacent cartilage is protected from damage due to overstraining. Experimentally it is not possible to measure load distribution and collagen strain inside articular cartilage (AC). Therefore, a numerical model was used to determine the mechanical conditions throughout the depth of the AC. Meniscus implants with different sizes and mechanical properties were evaluated. These were compared with healthy and with meniscectomized joints. To account for the time-dependent behavior 600 s of loading was simulated; results were visualized after 1 s and 600 s. Simulations showed that AC’s strains strongly depended on implant size and loading duration. They depended less on the stiffness of the implant material. With an oversized implant, collagen strains were particularly large in the femoral AC initially and further increased upon sustained loading. The severest compressive strains occurred after sustained loading in the meniscectomized joint. Strains with an undersized meniscus were comparable to a perfectly sized implant. In conclusion, these results support the hypothesis that an undersized implant may outperform an oversized one because it distributes stresses better in the most intensely loaded joint area." @default.
• W2168019073 created "2016-06-24" @default.
• W2168019073 creator A5081456981 @default.
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• W2168019073 date "2015-06-01" @default.
• W2168019073 modified "2023-10-18" @default.
• W2168019073 title "Meniscus replacement: Influence of geometrical mismatches on chondroprotective capabilities" @default.
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• W2168019073 doi "https://doi.org/10.1016/j.jbiomech.2015.02.063" @default.
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• W2168019073 hasPublicationYear "2015" @default.
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