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- W2168031871 endingPage "713" @default.
- W2168031871 startingPage "677" @default.
- W2168031871 abstract "Dynamic tuning of cellular responsiveness as a result of repeated stimuli improves the ability of cells to distinguish physiologically meaningful signals from each other and from noise. In particular, lymphocyte activation thresholds are subject to tuning, which contributes to maintaining tolerance to self-antigens and persisting foreign antigens, averting autoimmunity and immune pathogenesis, but allowing responses to strong, structured perturbations that are typically associated with acute infection. Such tuning is also implicated in conferring flexibility to positive selection in the thymus, in controlling the magnitude of the immune response, and in generating memory cells. Additional functional properties are dynamically and differentially tuned in parallel via subthreshold contact interactions between developing or mature lymphocytes and self-antigen-presenting cells. These interactions facilitate and regulate lymphocyte viability, maintain their functional integrity, and influence their responses to foreign antigens and accessory signals, qualitatively and quantitatively. Bidirectional tuning of T cells and antigen-presenting cells leads to the definition of homeostatic set points, thus maximizing clonal diversity." @default.
- W2168031871 created "2016-06-24" @default.
- W2168031871 creator A5042367370 @default.
- W2168031871 creator A5050068749 @default.
- W2168031871 date "2015-03-21" @default.
- W2168031871 modified "2023-10-18" @default.
- W2168031871 title "Dynamic Tuning of Lymphocytes: Physiological Basis, Mechanisms, and Function" @default.
- W2168031871 cites W109212507 @default.
- W2168031871 cites W1488377901 @default.
- W2168031871 cites W1497531634 @default.
- W2168031871 cites W1509142888 @default.
- W2168031871 cites W1509514214 @default.
- W2168031871 cites W1513014113 @default.
- W2168031871 cites W1544401280 @default.
- W2168031871 cites W1549160904 @default.
- W2168031871 cites W1563913816 @default.
- W2168031871 cites W1598920005 @default.
- W2168031871 cites W1608547690 @default.
- W2168031871 cites W1662182196 @default.
- W2168031871 cites W1735808189 @default.
- W2168031871 cites W1830427486 @default.
- W2168031871 cites W1859429438 @default.
- W2168031871 cites W1964077677 @default.
- W2168031871 cites W1966432380 @default.
- W2168031871 cites W1969958391 @default.
- W2168031871 cites W1971692004 @default.
- W2168031871 cites W1971806373 @default.
- W2168031871 cites W1974308995 @default.
- W2168031871 cites W1974424684 @default.
- W2168031871 cites W1975673932 @default.
- W2168031871 cites W1975950809 @default.
- W2168031871 cites W1981357515 @default.
- W2168031871 cites W1984726722 @default.
- W2168031871 cites W1986189485 @default.
- W2168031871 cites W1986533011 @default.
- W2168031871 cites W1989199118 @default.
- W2168031871 cites W1989620589 @default.
- W2168031871 cites W1990328636 @default.
- W2168031871 cites W1991988533 @default.
- W2168031871 cites W1992676642 @default.
- W2168031871 cites W1993263603 @default.
- W2168031871 cites W1993887733 @default.
- W2168031871 cites W1995538143 @default.
- W2168031871 cites W1995687337 @default.
- W2168031871 cites W2001640241 @default.
- W2168031871 cites W2001740313 @default.
- W2168031871 cites W2002641565 @default.
- W2168031871 cites W2007797448 @default.
- W2168031871 cites W2008403163 @default.
- W2168031871 cites W2011066310 @default.
- W2168031871 cites W2018947464 @default.
- W2168031871 cites W2022626810 @default.
- W2168031871 cites W2023261644 @default.
- W2168031871 cites W2023276714 @default.
- W2168031871 cites W2024449521 @default.
- W2168031871 cites W2025465431 @default.
- W2168031871 cites W2025567420 @default.
- W2168031871 cites W2026501453 @default.
- W2168031871 cites W2027284694 @default.
- W2168031871 cites W2036958461 @default.
- W2168031871 cites W2038169247 @default.
- W2168031871 cites W2039480619 @default.
- W2168031871 cites W2040586689 @default.
- W2168031871 cites W2041226315 @default.
- W2168031871 cites W2041603328 @default.
- W2168031871 cites W2043364533 @default.
- W2168031871 cites W2046421048 @default.
- W2168031871 cites W2048159226 @default.
- W2168031871 cites W2048245039 @default.
- W2168031871 cites W2048925354 @default.
- W2168031871 cites W2052249831 @default.
- W2168031871 cites W2057871932 @default.
- W2168031871 cites W2058158581 @default.
- W2168031871 cites W2059689009 @default.
- W2168031871 cites W2063116057 @default.
- W2168031871 cites W2064189084 @default.
- W2168031871 cites W2064628970 @default.
- W2168031871 cites W2065151627 @default.
- W2168031871 cites W2065514217 @default.
- W2168031871 cites W2066893530 @default.
- W2168031871 cites W2067025901 @default.
- W2168031871 cites W2067064730 @default.
- W2168031871 cites W2068888843 @default.
- W2168031871 cites W2073276303 @default.
- W2168031871 cites W2074391032 @default.
- W2168031871 cites W2076237275 @default.
- W2168031871 cites W2077884399 @default.
- W2168031871 cites W2078956671 @default.
- W2168031871 cites W2082761772 @default.
- W2168031871 cites W2084183699 @default.
- W2168031871 cites W2084388859 @default.
- W2168031871 cites W2084524844 @default.
- W2168031871 cites W2087733503 @default.
- W2168031871 cites W2095339383 @default.
- W2168031871 cites W2100412095 @default.
- W2168031871 cites W2104750134 @default.
- W2168031871 cites W2105130781 @default.
- W2168031871 cites W2105286884 @default.