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- W2168040106 abstract "Objective: Earlier studies have revealed sarcolemmal (SL) defects in congestive heart failure due to myocardial infarction; however, the mechanisms of SL changes in the failing heart are poorly understood. Since congestive heart failure is associated with various metabolic abnormalities including a deficiency of carnitine, we examined the effects of propionyl l-carnitine, a carnitine derivative, in animals with congestive heart failure. Methods: For this purpose, heart failure in rats was induced by occluding the coronary artery and 3 weeks later the animals were treated with 100 mg/kg (i.p. daily) propionyl l-carnitine for 4 weeks. The sham control group received saline injections. The animals were assessed for their left ventricular function. SL membranes were examined for Na+–K+ ATPase, Na+–Ca2+ exchange and adenylate cyclase activities. Results: A marked improvement in the attenuated left ventricular function of the experimental animals was seen upon treatment with propionyl l-carnitine. The SL adenylyl cyclase activities in control, untreated failing hearts and treated failing hearts were 590±36, 190±22 and 320±21 pmol cAMP/mg/10 min, whereas the SL Na+–K+ ATPase activities were 35.7±2.8, 22.5±2.4 and 30.1±2.8 μmol Pi/mg/h, respectively. Furthermore, the SL Na+-dependent Ca2+-uptake activity, which decreased in the failing hearts (4.6±0.4 vs. 9.3±0.7 nmol Ca2+/mg/2 s for control), was improved (6.8±0.5 nmol Ca2+/mg/2 s) significantly following treatment with propionyl l-carnitine. Conclusion: These results indicate that metabolic therapy with propionyl l-carnitine may attenuate defects in the SL membrane and thus may improve heart function in congestive heart failure due to myocardial infarction." @default.
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- W2168040106 date "1999-06-01" @default.
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- W2168040106 title "Beneficial effects of propionyl ?-carnitine on sarcolemmal changes in congestive heart failure due to myocardial infarction" @default.
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- W2168040106 doi "https://doi.org/10.1016/s0008-6363(99)00089-9" @default.
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