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- W216804313 abstract "Objective To observe the expression of P2X1 receptor in the detrusors of both normal rats and overactive bladder(OAB)rats. Evaluate the function and role of the P2X1 receptors in the OAB bladder,and discuss the relationship between P2X1 receptor and bladder dysfunction. Methods Divided the experimental rats into normal control group,model control group and OAB group after establishing the rats model of overactive bladder successfully. By RT-PCR and Immunohistochemistry detection methods,observe the expression of P2X1 receptor in the detrusors of both normalrats and OAB rats. Results The expression of P2X1 receptor was detected in the normal control group, model control group and also in OAB group.The expression of P2X1 receptor in the rats detrusor of normal control group is lower than that in the OAB group,with statistical significance(P 0.01). Conclusion The expression of P2X1 receptor in the detrusor of OAB rats is higher than that of normal rats,which demonstrating that P2X1 receptor may play an important role in the mechanism of OAB bladder systolic and diastolicdysfunction.This is likely related to bladder dysfunction closely ." @default.
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- W216804313 date "2009-01-01" @default.
- W216804313 modified "2023-09-28" @default.
- W216804313 title "Expression of P2X1 purinergic receptor in the rat detrusor of overactive bladder disease." @default.
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