FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168065604> ?p ?o ?g. }

• W2168065604 endingPage "309" @default.
• W2168065604 startingPage "300" @default.
• W2168065604 abstract "Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity and mortality in neonates and alternative strategies are needed. Stem cells have become a therapeutic option for other intestinal diseases, which share some features with NEC. We tested the hypothesis that amniotic fluid stem (AFS) cells exerted a beneficial effect in a neonatal rat model of NEC.Rats intraperitoneally injected with AFS cells and their controls (bone marrow mesenchymal stem cells, myoblast) were analysed for survival, behaviour, bowel imaging (MRI scan), histology, bowel absorption and motility, immunofluorescence for AFS cell detection, degree of gut inflammation (myeloperoxidase and malondialdehyde), and enterocyte apoptosis and proliferation.AFS cells integrated in the bowel wall and improved rat survival and clinical conditions, decreased NEC incidence and macroscopic gut damage, improved intestinal function, decreased bowel inflammation, increased enterocyte proliferation and reduced apoptosis. The beneficial effect was achieved via modulation of stromal cells expressing cyclooxygenase 2 in the lamina propria, as shown by survival studies using selective and non-selective cyclooxygenase 2 inhibitors. Interestingly, AFS cells differentially expressed genes of the Wnt/β-catenin pathway, which regulate intestinal epithelial stem cell function and cell migration and growth factors known to maintain gut epithelial integrity and reduce mucosal injury.We demonstrated here for the first time that AFS cells injected in an established model of NEC improve survival, clinical status, gut structure and function. Understanding the mechanism of this effect may help us to develop new cellular or pharmacological therapies for infants with NEC." @default.
• W2168065604 created "2016-06-24" @default.
• W2168065604 creator A5004848162 @default.
• W2168065604 creator A5009975977 @default.
• W2168065604 creator A5015565496 @default.
• W2168065604 creator A5016629990 @default.
• W2168065604 creator A5017930238 @default.
• W2168065604 creator A5021618906 @default.
• W2168065604 creator A5022764193 @default.
• W2168065604 creator A5037501835 @default.
• W2168065604 creator A5047109750 @default.
• W2168065604 creator A5048560367 @default.
• W2168065604 creator A5050444658 @default.
• W2168065604 creator A5058744331 @default.
• W2168065604 creator A5066209097 @default.
• W2168065604 creator A5071198012 @default.
• W2168065604 creator A5072120186 @default.
• W2168065604 creator A5072125789 @default.
• W2168065604 creator A5087571938 @default.
• W2168065604 creator A5089268626 @default.
• W2168065604 creator A5090148112 @default.
• W2168065604 creator A5090399752 @default.
• W2168065604 creator A5091278652 @default.
• W2168065604 date "2013-03-24" @default.
• W2168065604 modified "2023-10-16" @default.
• W2168065604 title "Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism" @default.
• W2168065604 cites W1539392991 @default.
• W2168065604 cites W1754398997 @default.
• W2168065604 cites W1762434727 @default.
• W2168065604 cites W1965732972 @default.
• W2168065604 cites W1966382927 @default.
• W2168065604 cites W1967269661 @default.
• W2168065604 cites W1968537403 @default.
• W2168065604 cites W1971024627 @default.
• W2168065604 cites W1975864305 @default.
• W2168065604 cites W1977527748 @default.
• W2168065604 cites W1981334287 @default.
• W2168065604 cites W1982248155 @default.
• W2168065604 cites W1986547199 @default.
• W2168065604 cites W1986711722 @default.
• W2168065604 cites W1992143229 @default.
• W2168065604 cites W2000584719 @default.
• W2168065604 cites W2010136306 @default.
• W2168065604 cites W2011721064 @default.
• W2168065604 cites W2011883974 @default.
• W2168065604 cites W2013860391 @default.
• W2168065604 cites W2018282805 @default.
• W2168065604 cites W2023553056 @default.
• W2168065604 cites W2034649992 @default.
• W2168065604 cites W2034891814 @default.
• W2168065604 cites W2037883636 @default.
• W2168065604 cites W2037926016 @default.
• W2168065604 cites W2038281554 @default.
• W2168065604 cites W2041436149 @default.
• W2168065604 cites W2044425784 @default.
• W2168065604 cites W2046089477 @default.
• W2168065604 cites W2046293893 @default.
• W2168065604 cites W2050291905 @default.
• W2168065604 cites W2051326485 @default.
• W2168065604 cites W2058319227 @default.
• W2168065604 cites W2058677985 @default.
• W2168065604 cites W2060146566 @default.
• W2168065604 cites W2067548751 @default.
• W2168065604 cites W2072191437 @default.
• W2168065604 cites W2073205471 @default.
• W2168065604 cites W2079172324 @default.
• W2168065604 cites W2084106740 @default.
• W2168065604 cites W2085045473 @default.
• W2168065604 cites W2086861900 @default.
• W2168065604 cites W2103272211 @default.
• W2168065604 cites W2106360005 @default.
• W2168065604 cites W2119207044 @default.
• W2168065604 cites W2120159169 @default.
• W2168065604 cites W2120528311 @default.
• W2168065604 cites W2126563561 @default.
• W2168065604 cites W2134234269 @default.
• W2168065604 cites W2145719229 @default.
• W2168065604 cites W2156260147 @default.
• W2168065604 cites W2156390096 @default.
• W2168065604 cites W2161858872 @default.
• W2168065604 cites W2162111206 @default.
• W2168065604 cites W2163194273 @default.
• W2168065604 cites W2164602079 @default.
• W2168065604 cites W2165438231 @default.
• W2168065604 cites W2166019746 @default.
• W2168065604 cites W4210999361 @default.
• W2168065604 doi "https://doi.org/10.1136/gutjnl-2012-303735" @default.
• W2168065604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23525603" @default.
• W2168065604 hasPublicationYear "2013" @default.
• W2168065604 type Work @default.
• W2168065604 sameAs 2168065604 @default.
• W2168065604 citedByCount "143" @default.
• W2168065604 countsByYear W21680656042013 @default.
• W2168065604 countsByYear W21680656042014 @default.
• W2168065604 countsByYear W21680656042015 @default.
• W2168065604 countsByYear W21680656042016 @default.
• W2168065604 countsByYear W21680656042017 @default.
• W2168065604 countsByYear W21680656042018 @default.

• next