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• W2168096165 abstract "The high affinity, selective dopamine transporter ligand GBR 12909 has served as a template for the design of two novel classes of dopamine transporter ligands. A series of 3-[2- (diarylmethoxyethyidenyl)]-N-substituted tropane derivatives were synthesized and the binding affinities of these compounds were determined at the dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in rat brain tissue preparations. The tropane derivatives were found to exhibit more potent affinity and selectivity for DAT than GBR 12909. From the SAR of the tropane analogues and GBR 12909, a novel series of 3-[2-(diarylmethoxyethylidenyl)]-Nsubstituted azetidine derivatives has been developed." @default.
• W2168096165 created "2016-06-24" @default.
• W2168096165 creator A5024858438 @default.
• W2168096165 date "2007-01-01" @default.
• W2168096165 modified "2023-09-27" @default.
• W2168096165 title "Synthesis and Biological Evaluation of Novel GBR 12909 Tropane and Azetidine Hybrid Analogues" @default.
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