FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168103311> ?p ?o ?g. }

• W2168103311 endingPage "411" @default.
• W2168103311 startingPage "404" @default.
• W2168103311 abstract "Metastasis is still the most serious reason for the high mortality of cancer patients. It is a complex process in which platelets play a crucial role. Several attempts have been performed to inhibit the metastatic process, some of these using modified liposomes. The aggregation behaviour of human platelets and HT29 colon carcinoma cells in the presence of liposomes with a modified surface has been investigated in the present study. Liposomes (PC/CH/DMPE) were unmodified, sterically stabilized by polyethylene glycol (PEG-DSPE), or equipped with the carbohydrate ligand sialyl Lewis(X) (conjugated to PEG-DMPE or DMPE as anchor) intended to specifically compete with ligands expressed by HT29 cells. We found in vitro that an addition of surface modified liposomes to human platelets in plasma caused an up to 2.9-fold increase in platelet aggregation. In addition, when HT29 tumor cells were mixed with platelets and surface modified liposomes, the number of tumor cells found in aggregates increased significantly from 8.3 % (only tumor cells) to 30.2 %. This result was supported by fluorescence micrographs demonstrating a strong association of platelets and liposomes around the tumor cells. In addition, a clear decrease in number and a change in the distribution of metastases after intravenous injection of HT29 cells in combination with liposomes was observed in vivo. While in control mice metastases in lung, liver and in intestine were prevailing, liposomal treatment resulted in a new localization of metastases in muscles. Taking together, the ability of surface modified liposomes to enhance aggregate formation of platelets and tumor cells has been demonstrated for the first time. The capability of these vesicles to interfere with the metastatic process might have implications for the use of such liposomes for therapeutic applications." @default.
• W2168103311 created "2016-06-24" @default.
• W2168103311 creator A5015081490 @default.
• W2168103311 creator A5039156712 @default.
• W2168103311 creator A5081015372 @default.
• W2168103311 date "2005-01-01" @default.
• W2168103311 modified "2023-10-16" @default.
• W2168103311 title "Effect of surface modified liposomes on the aggregation of platelets and tumor cells" @default.
• W2168103311 cites W1483494790 @default.
• W2168103311 cites W1509067292 @default.
• W2168103311 cites W1531203186 @default.
• W2168103311 cites W1963502802 @default.
• W2168103311 cites W1967826713 @default.
• W2168103311 cites W1997870290 @default.
• W2168103311 cites W2010965251 @default.
• W2168103311 cites W2013308107 @default.
• W2168103311 cites W2015487717 @default.
• W2168103311 cites W2017062022 @default.
• W2168103311 cites W2020654599 @default.
• W2168103311 cites W2021779392 @default.
• W2168103311 cites W2026294775 @default.
• W2168103311 cites W2026463198 @default.
• W2168103311 cites W2037161261 @default.
• W2168103311 cites W2039097438 @default.
• W2168103311 cites W2051616588 @default.
• W2168103311 cites W2053919896 @default.
• W2168103311 cites W2060529002 @default.
• W2168103311 cites W2065768184 @default.
• W2168103311 cites W2071902807 @default.
• W2168103311 cites W2086596141 @default.
• W2168103311 cites W2101764813 @default.
• W2168103311 cites W2109765003 @default.
• W2168103311 cites W2127113737 @default.
• W2168103311 cites W2135245673 @default.
• W2168103311 cites W2150531719 @default.
• W2168103311 cites W215298869 @default.
• W2168103311 cites W2160147504 @default.
• W2168103311 cites W2170200613 @default.
• W2168103311 cites W2246634871 @default.
• W2168103311 cites W2298229328 @default.
• W2168103311 cites W2402817846 @default.
• W2168103311 cites W2952111719 @default.
• W2168103311 doi "https://doi.org/10.1160/th04-12-0810" @default.
• W2168103311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16113832" @default.
• W2168103311 hasPublicationYear "2005" @default.
• W2168103311 type Work @default.
• W2168103311 sameAs 2168103311 @default.
• W2168103311 citedByCount "6" @default.
• W2168103311 countsByYear W21681033112018 @default.
• W2168103311 crossrefType "journal-article" @default.
• W2168103311 hasAuthorship W2168103311A5015081490 @default.
• W2168103311 hasAuthorship W2168103311A5039156712 @default.
• W2168103311 hasAuthorship W2168103311A5081015372 @default.
• W2168103311 hasConcept C10138342 @default.
• W2168103311 hasConcept C121608353 @default.
• W2168103311 hasConcept C12554922 @default.
• W2168103311 hasConcept C126322002 @default.
• W2168103311 hasConcept C150903083 @default.
• W2168103311 hasConcept C155619193 @default.
• W2168103311 hasConcept C16224149 @default.
• W2168103311 hasConcept C162324750 @default.
• W2168103311 hasConcept C185154212 @default.
• W2168103311 hasConcept C185592680 @default.
• W2168103311 hasConcept C202751555 @default.
• W2168103311 hasConcept C203014093 @default.
• W2168103311 hasConcept C207001950 @default.
• W2168103311 hasConcept C2776964284 @default.
• W2168103311 hasConcept C2777117008 @default.
• W2168103311 hasConcept C2777847059 @default.
• W2168103311 hasConcept C2779013556 @default.
• W2168103311 hasConcept C502942594 @default.
• W2168103311 hasConcept C54400483 @default.
• W2168103311 hasConcept C55493867 @default.
• W2168103311 hasConcept C71924100 @default.
• W2168103311 hasConcept C86803240 @default.
• W2168103311 hasConcept C89560881 @default.
• W2168103311 hasConceptScore W2168103311C10138342 @default.
• W2168103311 hasConceptScore W2168103311C121608353 @default.
• W2168103311 hasConceptScore W2168103311C12554922 @default.
• W2168103311 hasConceptScore W2168103311C126322002 @default.
• W2168103311 hasConceptScore W2168103311C150903083 @default.
• W2168103311 hasConceptScore W2168103311C155619193 @default.
• W2168103311 hasConceptScore W2168103311C16224149 @default.
• W2168103311 hasConceptScore W2168103311C162324750 @default.
• W2168103311 hasConceptScore W2168103311C185154212 @default.
• W2168103311 hasConceptScore W2168103311C185592680 @default.
• W2168103311 hasConceptScore W2168103311C202751555 @default.
• W2168103311 hasConceptScore W2168103311C203014093 @default.
• W2168103311 hasConceptScore W2168103311C207001950 @default.
• W2168103311 hasConceptScore W2168103311C2776964284 @default.
• W2168103311 hasConceptScore W2168103311C2777117008 @default.
• W2168103311 hasConceptScore W2168103311C2777847059 @default.
• W2168103311 hasConceptScore W2168103311C2779013556 @default.
• W2168103311 hasConceptScore W2168103311C502942594 @default.
• W2168103311 hasConceptScore W2168103311C54400483 @default.
• W2168103311 hasConceptScore W2168103311C55493867 @default.
• W2168103311 hasConceptScore W2168103311C71924100 @default.
• W2168103311 hasConceptScore W2168103311C86803240 @default.

• next