FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168104423> ?p ?o ?g. }

• W2168104423 endingPage "826" @default.
• W2168104423 startingPage "822" @default.
• W2168104423 abstract "Abstract Fanconi anemia (FA) is an autosomal recessive condition associated with congenital abnormalities, progressive pancytopenia, and a predisposition to leukemia and solid tumors. We studied a retrospective cohort of North American patients with FA. We calculated relative risks of cancer compared to the general population and cause-specific hazards of the first major adverse outcomes of FA: bone marrow transplantation (BMT) for marrow complications, acute myeloid leukemia (AML), solid tumors, or death from bone marrow failure. We also estimated the cumulative incidence of each adverse event in the presence of the competing risks. Among 145 patients with FA, 9 developed leukemia and 14 developed a total of 18 solid tumors. The ratio of observed to expected cancers (O/E ratio) was 50 for all cancers, 48 for all solid tumors, and 785 for leukemia; these increased risks were statistically significant. The highest solid tumor O/E ratios were 4317 for vulvar cancer, 2362 for esophageal cancer, and 706 for head and neck cancer. Cause-specific hazards of both death and AML peaked at 1%/y in teenage years; the hazard of BMT peaked at 4%/y at age 7. In contrast, the hazard of a solid tumor approached 8%/y by age 40 years. The cumulative incidence to age 48 was 10% for leukemia, 11% for death from marrow failure, 29% for a solid tumor, and 43% for BMT. The risk of a solid tumor may become even higher as death from aplastic anemia is reduced and as patients survive longer after BMT." @default.
• W2168104423 created "2016-06-24" @default.
• W2168104423 creator A5045246519 @default.
• W2168104423 creator A5084089970 @default.
• W2168104423 creator A5089073198 @default.
• W2168104423 date "2003-02-01" @default.
• W2168104423 modified "2023-10-10" @default.
• W2168104423 title "Cancer incidence in persons with Fanconi anemia" @default.
• W2168104423 cites W140046979 @default.
• W2168104423 cites W1549538719 @default.
• W2168104423 cites W1972125775 @default.
• W2168104423 cites W1991841649 @default.
• W2168104423 cites W2017694119 @default.
• W2168104423 cites W2035003065 @default.
• W2168104423 cites W2035625368 @default.
• W2168104423 cites W2092113847 @default.
• W2168104423 cites W2101161126 @default.
• W2168104423 cites W2127403065 @default.
• W2168104423 cites W2138746759 @default.
• W2168104423 cites W2142919660 @default.
• W2168104423 cites W2145582626 @default.
• W2168104423 cites W2149166037 @default.
• W2168104423 cites W2168571815 @default.
• W2168104423 cites W3117462546 @default.
• W2168104423 cites W3147894994 @default.
• W2168104423 cites W4252684946 @default.
• W2168104423 cites W4293241248 @default.
• W2168104423 doi "https://doi.org/10.1182/blood-2002-05-1498" @default.
• W2168104423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12393424" @default.
• W2168104423 hasPublicationYear "2003" @default.
• W2168104423 type Work @default.
• W2168104423 sameAs 2168104423 @default.
• W2168104423 citedByCount "438" @default.
• W2168104423 countsByYear W21681044232012 @default.
• W2168104423 countsByYear W21681044232013 @default.
• W2168104423 countsByYear W21681044232014 @default.
• W2168104423 countsByYear W21681044232015 @default.
• W2168104423 countsByYear W21681044232016 @default.
• W2168104423 countsByYear W21681044232017 @default.
• W2168104423 countsByYear W21681044232018 @default.
• W2168104423 countsByYear W21681044232019 @default.
• W2168104423 countsByYear W21681044232020 @default.
• W2168104423 countsByYear W21681044232021 @default.
• W2168104423 countsByYear W21681044232022 @default.
• W2168104423 countsByYear W21681044232023 @default.
• W2168104423 crossrefType "journal-article" @default.
• W2168104423 hasAuthorship W2168104423A5045246519 @default.
• W2168104423 hasAuthorship W2168104423A5084089970 @default.
• W2168104423 hasAuthorship W2168104423A5089073198 @default.
• W2168104423 hasBestOaLocation W21681044231 @default.
• W2168104423 hasConcept C104317684 @default.
• W2168104423 hasConcept C109159458 @default.
• W2168104423 hasConcept C121608353 @default.
• W2168104423 hasConcept C126322002 @default.
• W2168104423 hasConcept C134935766 @default.
• W2168104423 hasConcept C143998085 @default.
• W2168104423 hasConcept C207103383 @default.
• W2168104423 hasConcept C2778124228 @default.
• W2168104423 hasConcept C2778461978 @default.
• W2168104423 hasConcept C2779382419 @default.
• W2168104423 hasConcept C2780007613 @default.
• W2168104423 hasConcept C2780525284 @default.
• W2168104423 hasConcept C2781440808 @default.
• W2168104423 hasConcept C28328180 @default.
• W2168104423 hasConcept C2908647359 @default.
• W2168104423 hasConcept C2911091166 @default.
• W2168104423 hasConcept C44249647 @default.
• W2168104423 hasConcept C54355233 @default.
• W2168104423 hasConcept C55493867 @default.
• W2168104423 hasConcept C71924100 @default.
• W2168104423 hasConcept C86803240 @default.
• W2168104423 hasConcept C88879693 @default.
• W2168104423 hasConcept C90924648 @default.
• W2168104423 hasConcept C99454951 @default.
• W2168104423 hasConceptScore W2168104423C104317684 @default.
• W2168104423 hasConceptScore W2168104423C109159458 @default.
• W2168104423 hasConceptScore W2168104423C121608353 @default.
• W2168104423 hasConceptScore W2168104423C126322002 @default.
• W2168104423 hasConceptScore W2168104423C134935766 @default.
• W2168104423 hasConceptScore W2168104423C143998085 @default.
• W2168104423 hasConceptScore W2168104423C207103383 @default.
• W2168104423 hasConceptScore W2168104423C2778124228 @default.
• W2168104423 hasConceptScore W2168104423C2778461978 @default.
• W2168104423 hasConceptScore W2168104423C2779382419 @default.
• W2168104423 hasConceptScore W2168104423C2780007613 @default.
• W2168104423 hasConceptScore W2168104423C2780525284 @default.
• W2168104423 hasConceptScore W2168104423C2781440808 @default.
• W2168104423 hasConceptScore W2168104423C28328180 @default.
• W2168104423 hasConceptScore W2168104423C2908647359 @default.
• W2168104423 hasConceptScore W2168104423C2911091166 @default.
• W2168104423 hasConceptScore W2168104423C44249647 @default.
• W2168104423 hasConceptScore W2168104423C54355233 @default.
• W2168104423 hasConceptScore W2168104423C55493867 @default.
• W2168104423 hasConceptScore W2168104423C71924100 @default.
• W2168104423 hasConceptScore W2168104423C86803240 @default.
• W2168104423 hasConceptScore W2168104423C88879693 @default.
• W2168104423 hasConceptScore W2168104423C90924648 @default.
• W2168104423 hasConceptScore W2168104423C99454951 @default.

• next