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• W2168105870 abstract "Matrix degradation by metalloproteinases is considered a key feature in the loss of articular cartilage seen in many joint diseases. Membrane-type matrix metalloproteinase-3 (MT3-MMP) expression is elevated in human cartilage in end-stage osteoarthritis. We investigated whether MT3-MMP is similarly regulated in cartilage in two naturally occurring arthropathies in vivo and whether proinflammatory cytokines regulate its expression in vitro. MT3-MMP expression was evaluated in cartilage from horses with osteoarthritis and osteochondrosis and compared with age- and site-matched normal cartilage. MT3-MMP also was measured in normal cartilage stimulated with proinflammatory cytokines. MT3-MMP expression was not significantly altered in either osteoarthritis or osteochondrosis cartilage. However, gene expression was significantly downregulated by the addition of recombinant human interleukin-1β, oncostatin M, or tumor necrosis factor-α to normal cartilage explants. The results suggest that MT3-MMP may not have a role in matrix destruction in equine cartilage diseases. Further work is required to characterize its regulation and function." @default.
• W2168105870 created "2016-06-24" @default.
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• W2168105870 date "2008-01-01" @default.
• W2168105870 modified "2023-09-27" @default.
• W2168105870 title "MT3-MMP (MMP-16) is Downregulated by<i>In Vitro</i>Cytokine Stimulation of Cartilage, but Unaltered in Naturally Occurring Equine Osteoarthritis and Osteochondrosis" @default.
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• W2168105870 doi "https://doi.org/10.1080/03008200801913338" @default.
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• W2168105870 hasPublicationYear "2008" @default.
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