FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168118833> ?p ?o ?g. }

• W2168118833 endingPage "e17472" @default.
• W2168118833 startingPage "e17472" @default.
• W2168118833 abstract "Deoxynivalenol (DON) is a Fusarium derived mycotoxin, often occurring on cereals used for human and animal nutrition. The intestine, as prominent barrier for nutritional toxins, has to handle the mycotoxin from the mucosa protected luminal side (apical exposure), as well as already absorbed toxin, reaching the cells from basolateral side via the blood stream. In the present study, the impact of the direction of DON exposure on epithelial cell behaviour and intestinal barrier integrity was elucidated.A non-transformed intestinal porcine epithelial cell line (IPEC-J2), cultured in membrane inserts, serving as a polarised in vitro model to determine the effects of deoxynivalenol (DON) on cellular viability and tight junction integrity.Application of DON in concentrations up to 4000 ng/mL for 24, 48 and 72 hours on the basolateral side of membrane cultured polarised IPEC-J2 cells resulted in a breakdown of the integrity of cell connections measured by transepithelial electrical resistance (TEER), as well as a reduced expression of the tight junction proteins ZO-1 and claudin 3. Epithelial cell number decreased and nuclei size was enlarged after 72 h incubation of 4000 ng/mL DON from basolateral. Although necrosis or caspase 3 mediated apoptosis was not detectable after basolateral DON application, cell cycle analysis revealed a significant increase in DNA fragmentation, decrease in G0/G1 phase and slight increase in G2/M phase after 72 hours incubation with DON 2000 ng/mL.Severity of impact of the mycotoxin deoxynivalenol on the intestinal epithelial barrier is dependent on route of application. The epithelium appears to be rather resistant towards apical (luminal) DON application whereas the same toxin dose from basolateral severely undermines barrier integrity." @default.
• W2168118833 created "2016-06-24" @default.
• W2168118833 creator A5000272874 @default.
• W2168118833 creator A5011382543 @default.
• W2168118833 creator A5026402911 @default.
• W2168118833 creator A5026470015 @default.
• W2168118833 creator A5052687526 @default.
• W2168118833 creator A5073365474 @default.
• W2168118833 creator A5073664283 @default.
• W2168118833 creator A5082706506 @default.
• W2168118833 date "2011-02-25" @default.
• W2168118833 modified "2023-10-03" @default.
• W2168118833 title "Vulnerability of Polarised Intestinal Porcine Epithelial Cells to Mycotoxin Deoxynivalenol Depends on the Route of Application" @default.
• W2168118833 cites W1703412159 @default.
• W2168118833 cites W1967313050 @default.
• W2168118833 cites W1970727708 @default.
• W2168118833 cites W1971821680 @default.
• W2168118833 cites W1973986846 @default.
• W2168118833 cites W1978129793 @default.
• W2168118833 cites W1981393628 @default.
• W2168118833 cites W1987265868 @default.
• W2168118833 cites W1988618157 @default.
• W2168118833 cites W1989038708 @default.
• W2168118833 cites W2006823165 @default.
• W2168118833 cites W2011356699 @default.
• W2168118833 cites W2024920599 @default.
• W2168118833 cites W2026811557 @default.
• W2168118833 cites W2029685880 @default.
• W2168118833 cites W2031163754 @default.
• W2168118833 cites W2032612517 @default.
• W2168118833 cites W2035492472 @default.
• W2168118833 cites W2036619842 @default.
• W2168118833 cites W2037087465 @default.
• W2168118833 cites W2037414605 @default.
• W2168118833 cites W2042905219 @default.
• W2168118833 cites W2043325002 @default.
• W2168118833 cites W2051556121 @default.
• W2168118833 cites W2054163089 @default.
• W2168118833 cites W2054371494 @default.
• W2168118833 cites W2055959752 @default.
• W2168118833 cites W2065407996 @default.
• W2168118833 cites W2079078533 @default.
• W2168118833 cites W2081101945 @default.
• W2168118833 cites W2081185975 @default.
• W2168118833 cites W2081320138 @default.
• W2168118833 cites W2088810826 @default.
• W2168118833 cites W2091340154 @default.
• W2168118833 cites W2093658549 @default.
• W2168118833 cites W2113684814 @default.
• W2168118833 cites W2126432315 @default.
• W2168118833 cites W2136513361 @default.
• W2168118833 cites W2138310803 @default.
• W2168118833 cites W2148911589 @default.
• W2168118833 cites W2159745814 @default.
• W2168118833 cites W2170385301 @default.
• W2168118833 cites W2174478651 @default.
• W2168118833 cites W2198700387 @default.
• W2168118833 cites W2416053501 @default.
• W2168118833 cites W87529319 @default.
• W2168118833 doi "https://doi.org/10.1371/journal.pone.0017472" @default.
• W2168118833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3045462" @default.
• W2168118833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21364771" @default.
• W2168118833 hasPublicationYear "2011" @default.
• W2168118833 type Work @default.
• W2168118833 sameAs 2168118833 @default.
• W2168118833 citedByCount "102" @default.
• W2168118833 countsByYear W21681188332012 @default.
• W2168118833 countsByYear W21681188332013 @default.
• W2168118833 countsByYear W21681188332014 @default.
• W2168118833 countsByYear W21681188332015 @default.
• W2168118833 countsByYear W21681188332016 @default.
• W2168118833 countsByYear W21681188332017 @default.
• W2168118833 countsByYear W21681188332018 @default.
• W2168118833 countsByYear W21681188332019 @default.
• W2168118833 countsByYear W21681188332020 @default.
• W2168118833 countsByYear W21681188332021 @default.
• W2168118833 countsByYear W21681188332022 @default.
• W2168118833 countsByYear W21681188332023 @default.
• W2168118833 crossrefType "journal-article" @default.
• W2168118833 hasAuthorship W2168118833A5000272874 @default.
• W2168118833 hasAuthorship W2168118833A5011382543 @default.
• W2168118833 hasAuthorship W2168118833A5026402911 @default.
• W2168118833 hasAuthorship W2168118833A5026470015 @default.
• W2168118833 hasAuthorship W2168118833A5052687526 @default.
• W2168118833 hasAuthorship W2168118833A5073365474 @default.
• W2168118833 hasAuthorship W2168118833A5073664283 @default.
• W2168118833 hasAuthorship W2168118833A5082706506 @default.
• W2168118833 hasBestOaLocation W21681188331 @default.
• W2168118833 hasConcept C126322002 @default.
• W2168118833 hasConcept C1491633281 @default.
• W2168118833 hasConcept C177779419 @default.
• W2168118833 hasConcept C185592680 @default.
• W2168118833 hasConcept C18903297 @default.
• W2168118833 hasConcept C190283241 @default.
• W2168118833 hasConcept C191015642 @default.
• W2168118833 hasConcept C193176779 @default.
• W2168118833 hasConcept C2776889654 @default.
• W2168118833 hasConcept C2781077229 @default.

• next