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- W2168121525 abstract "β-(S-Methyl)thioaspartic acid occurs as a posttranslational modification at position 88 in Escherichia coli ribosomal protein S12, a position that is a mutational hotspot resulting in both antibiotic-resistant and antibiotic-sensitive phenotypes. Critical to research designed to determine the biological function of β-(S-methyl)thioaspartic acid will be the availability of synthetic β-(S-methyl)thioaspartic acid as well as derivatives designed for peptide incorporation. We report here the synthesis of β-(S-methyl)thioaspartic acid and derivatives. The installation of the β-methylthio moiety into the aspartic acid structure was accomplished by electrophilic sulfenylation of N-protected-l-aspartic acid derivatives with 2,4-dinitrophenyl methyl disulfide. Following this key transformation, we were able to prepare protected β-(S-methyl)thioaspartic acid derivative suitable for peptide coupling." @default.
- W2168121525 created "2016-06-24" @default.
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- W2168121525 date "2008-06-01" @default.
- W2168121525 modified "2023-09-23" @default.
- W2168121525 title "Synthesis of β-(S-methyl)thioaspartic acid and derivatives" @default.
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- W2168121525 doi "https://doi.org/10.1016/j.bmc.2008.04.069" @default.
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