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- W2168126281 abstract "To know which anatomical factors may constrain long-term functional recovery after cerebral insult remains a critical issue. To obtain a better knowledge of neuroplasticity implies a fine-grained understanding of how the brain orchestrates the functional interactions through its complex networks to implement high-level cognition, and subsequently produce sophisticated forms of behavior. In such a perspective, the role of axonal connectivity is crucial in ensuring inter-regional functional integration across neurocognitive systems.1 Tractography imaging and the revival of anatomic dissections have revolutionized our knowledge about the precise organization of anatomical connectivity. Interestingly, white matter (WM) damage resulting in disconnections may constitute a prominent source of cognitive impairments,2,3 with little compensatory likelihood, given the low level of neuroplasticity for long-range WM connections.4 Indeed, axonal injury could prevent any possibility of brain-wide reorganization. Although the limitation imposed by WM disconnection in functional recovery was demonstrated in brain tumor surgery,4 evidence is scarce following penetrating traumatic brain injury (pTBI).4" @default.
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- W2168126281 date "2015-03-06" @default.
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- W2168126281 title "The role of cerebral disconnection in cognitive recovery after brain damage" @default.
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- W2168126281 doi "https://doi.org/10.1212/wnl.0000000000001453" @default.
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