Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168128529> ?p ?o ?g. }
- W2168128529 abstract "Stress is a response of the central nervous system to environmental stimuli perceived as a threat to homeostasis. The stress response triggers the generation of neurotransmitters and hormones from the hypothalamus pituitary adrenal axis, sympathetic axis and brain gut axis, and in this way modulates the intestinal immune system. The effects of psychological stress on intestinal immunity have been investigated mostly with the restraint/immobilization rodent model, resulting in an up or down modulation of SIgA levels depending on the intensity and time of exposure to stress. SIgA is a protein complex formed by dimeric (dIgA) or polymeric IgA (pIgA) and the secretory component (SC), a peptide derived from the polymeric immunoglobulin receptor (pIgR). The latter receptor is a transmembrane protein expressed on the basolateral side of gut epithelial cells, where it uptakes dIgA or pIgA released by plasma cells in the lamina propria. As a result, the IgA-pIgR complex is formed and transported by vesicles to the apical side of epithelial cells. pIgR is then cleaved to release SIgA into the luminal secretions of gut. Down modulation of SIgA associated with stress can have negative repercussions on intestinal function and integrity. This can take the form of increased adhesion of pathogenic agents to the intestinal epithelium and/or an altered balance of inflammation leading to greater intestinal permeability. Most studies on the molecular and biochemical mechanisms involved in the stress response have focused on systemic immunity. The present review analyzes the impact of stress (mostly by restraint/immobilization, but also with mention of other models) on the generation of SIgA, pIgR and other humoral and cellular components involved in the intestinal immune response. Insights into these mechanisms could lead to better therapies for protecting against pathogenic agents and avoiding epithelial tissue damage by modulating intestinal inflammation." @default.
- W2168128529 created "2016-06-24" @default.
- W2168128529 creator A5003756815 @default.
- W2168128529 creator A5029119570 @default.
- W2168128529 creator A5048844720 @default.
- W2168128529 creator A5052727140 @default.
- W2168128529 creator A5058864551 @default.
- W2168128529 creator A5065529255 @default.
- W2168128529 creator A5069821924 @default.
- W2168128529 date "2013-01-01" @default.
- W2168128529 modified "2023-10-18" @default.
- W2168128529 title "Stress modulates intestinal secretory immunoglobulin A" @default.
- W2168128529 cites W1552635305 @default.
- W2168128529 cites W1570229015 @default.
- W2168128529 cites W1639792556 @default.
- W2168128529 cites W1895482825 @default.
- W2168128529 cites W1966452112 @default.
- W2168128529 cites W1967691905 @default.
- W2168128529 cites W1972179606 @default.
- W2168128529 cites W1972557504 @default.
- W2168128529 cites W1977774953 @default.
- W2168128529 cites W1982189917 @default.
- W2168128529 cites W1987810117 @default.
- W2168128529 cites W1991123229 @default.
- W2168128529 cites W1993983321 @default.
- W2168128529 cites W1997648536 @default.
- W2168128529 cites W2000947467 @default.
- W2168128529 cites W2004818680 @default.
- W2168128529 cites W2006027642 @default.
- W2168128529 cites W2006318861 @default.
- W2168128529 cites W2007384208 @default.
- W2168128529 cites W2008501231 @default.
- W2168128529 cites W2019921788 @default.
- W2168128529 cites W2023334981 @default.
- W2168128529 cites W2024825121 @default.
- W2168128529 cites W2026429915 @default.
- W2168128529 cites W2027606763 @default.
- W2168128529 cites W2029493862 @default.
- W2168128529 cites W2029498867 @default.
- W2168128529 cites W2031026757 @default.
- W2168128529 cites W2033729278 @default.
- W2168128529 cites W2034621596 @default.
- W2168128529 cites W2039841890 @default.
- W2168128529 cites W2041155701 @default.
- W2168128529 cites W2044073180 @default.
- W2168128529 cites W2047339004 @default.
- W2168128529 cites W2048814693 @default.
- W2168128529 cites W2049357172 @default.
- W2168128529 cites W2054483041 @default.
- W2168128529 cites W2057534786 @default.
- W2168128529 cites W2062519390 @default.
- W2168128529 cites W2065174433 @default.
- W2168128529 cites W2065382235 @default.
- W2168128529 cites W2073965758 @default.
- W2168128529 cites W2075260782 @default.
- W2168128529 cites W2075949774 @default.
- W2168128529 cites W2080854072 @default.
- W2168128529 cites W2085600022 @default.
- W2168128529 cites W2087525289 @default.
- W2168128529 cites W2087869665 @default.
- W2168128529 cites W2090836952 @default.
- W2168128529 cites W2091057898 @default.
- W2168128529 cites W2095004479 @default.
- W2168128529 cites W2096699747 @default.
- W2168128529 cites W2097193630 @default.
- W2168128529 cites W2098449174 @default.
- W2168128529 cites W2100203899 @default.
- W2168128529 cites W2102237050 @default.
- W2168128529 cites W2108859484 @default.
- W2168128529 cites W2110729358 @default.
- W2168128529 cites W2113940450 @default.
- W2168128529 cites W2118667105 @default.
- W2168128529 cites W2119766596 @default.
- W2168128529 cites W2127590896 @default.
- W2168128529 cites W2135397870 @default.
- W2168128529 cites W2136054045 @default.
- W2168128529 cites W2137577469 @default.
- W2168128529 cites W2140418964 @default.
- W2168128529 cites W2144451848 @default.
- W2168128529 cites W2163037006 @default.
- W2168128529 cites W2165922813 @default.
- W2168128529 cites W2186875195 @default.
- W2168128529 cites W2319599345 @default.
- W2168128529 cites W2416901430 @default.
- W2168128529 cites W2075847527 @default.
- W2168128529 doi "https://doi.org/10.3389/fnint.2013.00086" @default.
- W2168128529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3845795" @default.
- W2168128529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24348350" @default.
- W2168128529 hasPublicationYear "2013" @default.
- W2168128529 type Work @default.
- W2168128529 sameAs 2168128529 @default.
- W2168128529 citedByCount "68" @default.
- W2168128529 countsByYear W21681285292014 @default.
- W2168128529 countsByYear W21681285292015 @default.
- W2168128529 countsByYear W21681285292016 @default.
- W2168128529 countsByYear W21681285292017 @default.
- W2168128529 countsByYear W21681285292018 @default.
- W2168128529 countsByYear W21681285292019 @default.
- W2168128529 countsByYear W21681285292020 @default.
- W2168128529 countsByYear W21681285292021 @default.