FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168129243> ?p ?o ?g. }

• W2168129243 endingPage "1671" @default.
• W2168129243 startingPage "1664" @default.
• W2168129243 abstract "Chromosome Segregation and Genome Integrity At cell division, both daughter cells receive only one copy of the parental genome. Not surprisingly, chromatin plays a role at numerous stages to ensure that genome segregation occurs with high fidelity. First, each chromosome is duplicated to produce two identical chromosomes called sister chromatids. Second, sister chromatids become paired, or glued together, along the entire chromosome length (Sumner 1991; Selig et al. 1992; Guacci et al. 1994). This pairing, or cohesion, provides a mechanism by which the identity of sister chromatids can be maintained over time. Third, sister pairs associate with the mitotic spindle apparatus via kinetochores, specialized protein complexes that assemble on centromeres. This association produces a highly defined geometry: The kinetochore of one chromatid associates with microtubules from the spindle pole opposite that of her sister. Cohesion between sister chromatids facilitates this orientation, most probably by physically constraining sister kinetochores to face in opposite directions (Rieder 1982; Waters et al. 1996; Michaelis et al. 1997; Tanaka et al. 2000a). Fourth, kinetochores associated with spindle microtubules generate poleward-pulling forces that act to separate sister chromatids (McNeill and Berns 1981; Rieder et al. 1986; Skibbens et al. 1995). Cohesion opposes these kinetochore pulling forces, stretching the intervening chromatin and generating tension across the chromatid pair. This tension is critical for coordinating sister chromatid movement during mitosis (Skibbens et al. 1995), and for cell cycle progression. In support of the latter, kinetochores capture microtubules by chance, such that initial attachments are not always correct (Nicklas 1997). Fortunately, cells have evolved a mitotic checkpoint mechanism that halts cell cycle progression in response to inappropriate kinetochore–microtubule interactions or in the absence of tension (Hoyt et al. 1991; Li and Murray 1991; Nicklas et al. 1995; Li and Nicklas 1997; Waters et al. 1998, 1999; Skibbens et al. 1999). Only after all of the chromatid pairs are properly oriented to the mitotic spindle apparatus does dissolution of cohesion occur, allowing sister chromatids to segregate away from each other and move into the newly forming daughter cells (Fig. 1). Numerous advances have facilitated the molecular dissection of cis and trans factors required for establishing sister chromatid cohesion. A seminal finding that propelled forward our understanding of cohesion and cell cycle regulation was that anaphase onset (sister separation) and exit from mitosis (M-phase to interphase transition) are separable events: The dissolution of sister chromatid cohesion could now be studied in an isolated context (Holloway et al. 1993; Surana et al. 1993; Irniger et al. 1995). Other advancements, including the adaptations of fluorescent in situ hybridization (FISH) and GFP-tagged repressor/operator methodologies, allowed for the visualization of individual sister chromatid loci in yeast cells, an organism in which mutants are readily generated and the genome sequence is known (Guacci et al. 1994; Straight et al. 1996; Michaelis et al. 1997; Megee and Koshland 1999). Finally, analyses of DNA from coimmunoprecipitates, in combination with functional assays of cohesion in minichromosomes, have provided a vehicle to identify DNA sequences that participate in cohesion (Dedon et al. 1991; Meluh and Koshland 1997; Blat and Kleckner 1999; Megee and Koshland 1999; Megee et al. 1999; Tanaka et al. 1999). In this review, we take a cerevisiae-centric view of the recent advances that have brought insights, as well as intrigue, to the mechanism by which cis and trans factors participate in cohesion establishment." @default.
• W2168129243 created "2016-06-24" @default.
• W2168129243 creator A5020815987 @default.
• W2168129243 date "2000-11-01" @default.
• W2168129243 modified "2023-10-01" @default.
• W2168129243 title "Holding Your Own: Establishing Sister Chromatid Cohesion" @default.
• W2168129243 cites W109419785 @default.
• W2168129243 cites W1509135035 @default.
• W2168129243 cites W1540274642 @default.
• W2168129243 cites W1552586455 @default.
• W2168129243 cites W1597612612 @default.
• W2168129243 cites W1611596666 @default.
• W2168129243 cites W1638194466 @default.
• W2168129243 cites W1826500529 @default.
• W2168129243 cites W1849604341 @default.
• W2168129243 cites W1855895296 @default.
• W2168129243 cites W1856940032 @default.
• W2168129243 cites W1862400400 @default.
• W2168129243 cites W1865573391 @default.
• W2168129243 cites W1898400269 @default.
• W2168129243 cites W1924427056 @default.
• W2168129243 cites W1934183749 @default.
• W2168129243 cites W1937702437 @default.
• W2168129243 cites W1940379257 @default.
• W2168129243 cites W1963648581 @default.
• W2168129243 cites W1963750681 @default.
• W2168129243 cites W1967920462 @default.
• W2168129243 cites W1968938287 @default.
• W2168129243 cites W1971799079 @default.
• W2168129243 cites W1972307085 @default.
• W2168129243 cites W1973916918 @default.
• W2168129243 cites W1974062319 @default.
• W2168129243 cites W1976067971 @default.
• W2168129243 cites W1981772689 @default.
• W2168129243 cites W1983412918 @default.
• W2168129243 cites W1983636619 @default.
• W2168129243 cites W1988475931 @default.
• W2168129243 cites W1993073412 @default.
• W2168129243 cites W1999044166 @default.
• W2168129243 cites W2007093272 @default.
• W2168129243 cites W2007853809 @default.
• W2168129243 cites W2013298631 @default.
• W2168129243 cites W2017863712 @default.
• W2168129243 cites W2018705198 @default.
• W2168129243 cites W2019918748 @default.
• W2168129243 cites W2026061099 @default.
• W2168129243 cites W2031077971 @default.
• W2168129243 cites W2034217568 @default.
• W2168129243 cites W2034789837 @default.
• W2168129243 cites W2038932046 @default.
• W2168129243 cites W2040433610 @default.
• W2168129243 cites W2045590352 @default.
• W2168129243 cites W2047458668 @default.
• W2168129243 cites W2054337761 @default.
• W2168129243 cites W2058945227 @default.
• W2168129243 cites W2059634393 @default.
• W2168129243 cites W2063240589 @default.
• W2168129243 cites W2063509605 @default.
• W2168129243 cites W2063759666 @default.
• W2168129243 cites W2066185444 @default.
• W2168129243 cites W2066892858 @default.
• W2168129243 cites W2069559082 @default.
• W2168129243 cites W2078028629 @default.
• W2168129243 cites W2084343743 @default.
• W2168129243 cites W2091502861 @default.
• W2168129243 cites W2095558945 @default.
• W2168129243 cites W2097201830 @default.
• W2168129243 cites W2102155883 @default.
• W2168129243 cites W2106049510 @default.
• W2168129243 cites W2108688550 @default.
• W2168129243 cites W2120295812 @default.
• W2168129243 cites W2120917736 @default.
• W2168129243 cites W2125240364 @default.
• W2168129243 cites W2126428759 @default.
• W2168129243 cites W2126615528 @default.
• W2168129243 cites W2127315808 @default.
• W2168129243 cites W2127886165 @default.
• W2168129243 cites W2130141461 @default.
• W2168129243 cites W2133188555 @default.
• W2168129243 cites W2142157138 @default.
• W2168129243 cites W2146084258 @default.
• W2168129243 cites W2148140410 @default.
• W2168129243 cites W2152414953 @default.
• W2168129243 cites W2153442585 @default.
• W2168129243 cites W2154241215 @default.
• W2168129243 cites W2159879351 @default.
• W2168129243 cites W2163943304 @default.
• W2168129243 cites W2175705587 @default.
• W2168129243 cites W2186190038 @default.
• W2168129243 cites W2186830799 @default.
• W2168129243 doi "https://doi.org/10.1101/gr.153600" @default.
• W2168129243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11076851" @default.
• W2168129243 hasPublicationYear "2000" @default.
• W2168129243 type Work @default.
• W2168129243 sameAs 2168129243 @default.
• W2168129243 citedByCount "42" @default.
• W2168129243 countsByYear W21681292432012 @default.
• W2168129243 countsByYear W21681292432013 @default.

• next