FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168133067> ?p ?o ?g. }

• W2168133067 endingPage "3101" @default.
• W2168133067 startingPage "3089" @default.
• W2168133067 abstract "The molecular mechanisms that promote progression of localized prostate cancer to hormone-refractory and disseminated disease are poorly understood. Prolactin (Prl) is a local growth factor produced in high-grade prostate cancer, and exogenously added Prl in tissue or explant cultures of normal and malignant prostate is a strong mitogen and survival factor for prostate epithelium. The key signaling proteins that mediate the biological effects of Prl in prostate cancer are Signal Transducer and Activator of Transcription (Stat)-5a/5b via activation of Janus kinase-2. Importantly, inhibition of Stat5a/b in prostate cancer cells induces apoptotic death. Using a specific Prl receptor antagonist (Delta1-9G129R-hPRL), we demonstrate here for the first time that autocrine Prl in androgen-independent human prostate cancer cells promotes cell viability via Stat5 signaling pathway. Furthermore, we examined a unique clinical material of human hormone refractory prostate cancers and metastases and show that autocrine Prl is expressed in 54% of hormone-refractory clinical human prostate cancers and 62% prostate cancer metastases. Finally, we demonstrate that autocrine Prl is expressed from both the proximal and distal promoters of the Prl gene in clinical human prostate cancers and in vivo and in vitro human prostate cancer models, independently of pituitary transcription factor-1 (Pit-1). Collectively, the data provide novel evidence for the concept that autocrine Prl signaling pathway is involved in growth of hormone-refractory and metastatic prostate cancer. The study also provides support for the use of Prl receptor antagonists or other therapeutic strategies to block the Prl-Janus kinase-2-Stat5 signaling pathway in advanced prostate cancer." @default.
• W2168133067 created "2016-06-24" @default.
• W2168133067 creator A5000570624 @default.
• W2168133067 creator A5024459881 @default.
• W2168133067 creator A5025695753 @default.
• W2168133067 creator A5040800642 @default.
• W2168133067 creator A5041012326 @default.
• W2168133067 creator A5041638532 @default.
• W2168133067 creator A5056302482 @default.
• W2168133067 creator A5064081956 @default.
• W2168133067 creator A5065388539 @default.
• W2168133067 creator A5067554686 @default.
• W2168133067 creator A5072652868 @default.
• W2168133067 creator A5077228679 @default.
• W2168133067 creator A5085775392 @default.
• W2168133067 creator A5089377917 @default.
• W2168133067 date "2007-07-01" @default.
• W2168133067 modified "2023-09-30" @default.
• W2168133067 title "Autocrine Prolactin Promotes Prostate Cancer Cell Growth via Janus Kinase-2-Signal Transducer and Activator of Transcription-5a/b Signaling Pathway" @default.
• W2168133067 cites W1486018587 @default.
• W2168133067 cites W1534952091 @default.
• W2168133067 cites W1559736216 @default.
• W2168133067 cites W1889623179 @default.
• W2168133067 cites W1969589565 @default.
• W2168133067 cites W1973946175 @default.
• W2168133067 cites W1976292966 @default.
• W2168133067 cites W1986137495 @default.
• W2168133067 cites W1986373643 @default.
• W2168133067 cites W2005658600 @default.
• W2168133067 cites W2007468664 @default.
• W2168133067 cites W2011501880 @default.
• W2168133067 cites W2012277787 @default.
• W2168133067 cites W2020894510 @default.
• W2168133067 cites W2021515327 @default.
• W2168133067 cites W2023759516 @default.
• W2168133067 cites W2029122973 @default.
• W2168133067 cites W2040836033 @default.
• W2168133067 cites W2046707099 @default.
• W2168133067 cites W2054923884 @default.
• W2168133067 cites W2058051750 @default.
• W2168133067 cites W2061911613 @default.
• W2168133067 cites W206263215 @default.
• W2168133067 cites W2067884089 @default.
• W2168133067 cites W2088371750 @default.
• W2168133067 cites W2090844907 @default.
• W2168133067 cites W2091571305 @default.
• W2168133067 cites W2094098906 @default.
• W2168133067 cites W2098834104 @default.
• W2168133067 cites W2106480944 @default.
• W2168133067 cites W2112609982 @default.
• W2168133067 cites W2132807638 @default.
• W2168133067 cites W2157116140 @default.
• W2168133067 cites W2159132187 @default.
• W2168133067 cites W2165122774 @default.
• W2168133067 doi "https://doi.org/10.1210/en.2006-1761" @default.
• W2168133067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17412813" @default.
• W2168133067 hasPublicationYear "2007" @default.
• W2168133067 type Work @default.
• W2168133067 sameAs 2168133067 @default.
• W2168133067 citedByCount "117" @default.
• W2168133067 countsByYear W21681330672012 @default.
• W2168133067 countsByYear W21681330672013 @default.
• W2168133067 countsByYear W21681330672014 @default.
• W2168133067 countsByYear W21681330672015 @default.
• W2168133067 countsByYear W21681330672016 @default.
• W2168133067 countsByYear W21681330672017 @default.
• W2168133067 countsByYear W21681330672018 @default.
• W2168133067 countsByYear W21681330672019 @default.
• W2168133067 countsByYear W21681330672020 @default.
• W2168133067 countsByYear W21681330672021 @default.
• W2168133067 countsByYear W21681330672022 @default.
• W2168133067 crossrefType "journal-article" @default.
• W2168133067 hasAuthorship W2168133067A5000570624 @default.
• W2168133067 hasAuthorship W2168133067A5024459881 @default.
• W2168133067 hasAuthorship W2168133067A5025695753 @default.
• W2168133067 hasAuthorship W2168133067A5040800642 @default.
• W2168133067 hasAuthorship W2168133067A5041012326 @default.
• W2168133067 hasAuthorship W2168133067A5041638532 @default.
• W2168133067 hasAuthorship W2168133067A5056302482 @default.
• W2168133067 hasAuthorship W2168133067A5064081956 @default.
• W2168133067 hasAuthorship W2168133067A5065388539 @default.
• W2168133067 hasAuthorship W2168133067A5067554686 @default.
• W2168133067 hasAuthorship W2168133067A5072652868 @default.
• W2168133067 hasAuthorship W2168133067A5077228679 @default.
• W2168133067 hasAuthorship W2168133067A5085775392 @default.
• W2168133067 hasAuthorship W2168133067A5089377917 @default.
• W2168133067 hasBestOaLocation W21681330671 @default.
• W2168133067 hasConcept C121608353 @default.
• W2168133067 hasConcept C126322002 @default.
• W2168133067 hasConcept C128240485 @default.
• W2168133067 hasConcept C134018914 @default.
• W2168133067 hasConcept C170493617 @default.
• W2168133067 hasConcept C2776235491 @default.
• W2168133067 hasConcept C2780192828 @default.
• W2168133067 hasConcept C502942594 @default.
• W2168133067 hasConcept C71924100 @default.
• W2168133067 hasConcept C86803240 @default.
• W2168133067 hasConceptScore W2168133067C121608353 @default.

• next