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- W2168155462 abstract "Clinicians are faced with an expansive array of treatment choices when caring for patients with type 2 diabetes. Because patient compliance may be affected when media sensationalism about controversial findings is misunderstood, we sought to clarify the recent controversy surrounding the cardiovascular and bone-health risks of thiazolidinediones, the risk of lactic acidosis with metformin, and the risk of hypoglycemia with oral therapies. The side effect profile of thiazolidinediones includes fluid retention, heart failure; and an increased risk of fracture. A recent controversial meta-analysis suggested that rosiglitazone increases the risk of myocardial infarction, which is possibly related to thiazolidinedione-induced lipid changes, weight gain, congestive heart failure, and anemia. Metformin is restricted to patients with normal renal function because of concerns that metformin may cause lactic acidosis. However, few cases of metformin-associated lactic acidosis have been reported, and most have occurred in patients with other reasons for developing lactic acidosis, such as sepsis or renal failure. Although the use of metformin continues to increase, observational studies have not been able to demonstrate an increased incidence of lactic acidosis in metformin-treated patients, even when it is used in populations with relative contraindications. Some oral hypoglycemic medications can cause hypoglycemia. Hypoglycemia is especially common in older patients, alcoholics, and patients with liver or renal disease. Patients on sulfonylureas and meglitinides have the highest incidence of hypoglycemia because of their pharmacological action of increasing insulin secretion. Of the sulfonylureas, glyburide presents the highest risk of hypoglycemia. Combination therapies, especially those regimens containing a sulfonylurea, increase the risk of hypoglycemia. Mt Sinai J Med 76:234–243, 2009. © 2009 Mount Sinai School of Medicine" @default.
- W2168155462 created "2016-06-24" @default.
- W2168155462 creator A5042176376 @default.
- W2168155462 creator A5046399206 @default.
- W2168155462 date "2009-05-06" @default.
- W2168155462 modified "2023-10-14" @default.
- W2168155462 title "Balancing Risk and Benefit with Oral Hypoglycemic Drugs" @default.
- W2168155462 cites W1527881916 @default.
- W2168155462 cites W1531432037 @default.
- W2168155462 cites W157477409 @default.
- W2168155462 cites W172609984 @default.
- W2168155462 cites W1963995578 @default.
- W2168155462 cites W1968330079 @default.
- W2168155462 cites W1969276663 @default.
- W2168155462 cites W1971827509 @default.
- W2168155462 cites W1972136146 @default.
- W2168155462 cites W1974657065 @default.
- W2168155462 cites W1976942305 @default.
- W2168155462 cites W1977390060 @default.
- W2168155462 cites W1981978041 @default.
- W2168155462 cites W1987491854 @default.
- W2168155462 cites W1988135937 @default.
- W2168155462 cites W1989405402 @default.
- W2168155462 cites W1990421974 @default.
- W2168155462 cites W1994030315 @default.
- W2168155462 cites W1994117393 @default.
- W2168155462 cites W1995069275 @default.
- W2168155462 cites W1997416444 @default.
- W2168155462 cites W2000223845 @default.
- W2168155462 cites W2000242491 @default.
- W2168155462 cites W2004271550 @default.
- W2168155462 cites W2004716488 @default.
- W2168155462 cites W2004885518 @default.
- W2168155462 cites W2006837571 @default.
- W2168155462 cites W2008001887 @default.
- W2168155462 cites W2008775815 @default.
- W2168155462 cites W2014346836 @default.
- W2168155462 cites W2015279471 @default.
- W2168155462 cites W2016818962 @default.
- W2168155462 cites W2018075481 @default.
- W2168155462 cites W2020741797 @default.
- W2168155462 cites W2021390129 @default.
- W2168155462 cites W2022248805 @default.
- W2168155462 cites W2024727673 @default.
- W2168155462 cites W2024874163 @default.
- W2168155462 cites W2026186581 @default.
- W2168155462 cites W2032682780 @default.
- W2168155462 cites W2033737255 @default.
- W2168155462 cites W2035840172 @default.
- W2168155462 cites W2046503553 @default.
- W2168155462 cites W2055769770 @default.
- W2168155462 cites W2056347227 @default.
- W2168155462 cites W2056622903 @default.
- W2168155462 cites W2056726092 @default.
- W2168155462 cites W2058528681 @default.
- W2168155462 cites W2058802517 @default.
- W2168155462 cites W2062141355 @default.
- W2168155462 cites W2063045277 @default.
- W2168155462 cites W2063586398 @default.
- W2168155462 cites W2064641938 @default.
- W2168155462 cites W2067763579 @default.
- W2168155462 cites W2073026477 @default.
- W2168155462 cites W2075222273 @default.
- W2168155462 cites W2078508655 @default.
- W2168155462 cites W2081276121 @default.
- W2168155462 cites W2085095809 @default.
- W2168155462 cites W2085925007 @default.
- W2168155462 cites W2086417193 @default.
- W2168155462 cites W2087748317 @default.
- W2168155462 cites W2089225574 @default.
- W2168155462 cites W2093718596 @default.
- W2168155462 cites W2098099316 @default.
- W2168155462 cites W2099673402 @default.
- W2168155462 cites W2104113021 @default.
- W2168155462 cites W2107235161 @default.
- W2168155462 cites W2108597252 @default.
- W2168155462 cites W2116822087 @default.
- W2168155462 cites W2120774442 @default.
- W2168155462 cites W2125827301 @default.
- W2168155462 cites W2127125241 @default.
- W2168155462 cites W2129451833 @default.
- W2168155462 cites W2134605962 @default.
- W2168155462 cites W2138514161 @default.
- W2168155462 cites W2140090067 @default.
- W2168155462 cites W2141713511 @default.
- W2168155462 cites W2142027700 @default.
- W2168155462 cites W2144330800 @default.
- W2168155462 cites W2146354558 @default.
- W2168155462 cites W2149460582 @default.
- W2168155462 cites W2151616821 @default.
- W2168155462 cites W2153449155 @default.
- W2168155462 cites W2158727328 @default.
- W2168155462 cites W2159969745 @default.
- W2168155462 cites W2164160382 @default.
- W2168155462 cites W2164367541 @default.
- W2168155462 cites W2164584957 @default.
- W2168155462 cites W2165815833 @default.
- W2168155462 cites W2166179667 @default.