FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168157584> ?p ?o ?g. }

• W2168157584 endingPage "866" @default.
• W2168157584 startingPage "862" @default.
• W2168157584 abstract "Objectives: Antibodies against granulocyte colony stimulating factor are frequently found in patients with Felty’s syndrome (FS). In this study, we examined the prevalence of antibodies against two other granulopoietic cytokines: granulocyte−macrophage colony stimulating factor (GM-CSF) and interleukin-3 (IL3). Methods: Sera of 32 patients with FS, 20 normocytic patients with rheumatoid arthritis (RA), and 72 healthy individuals were screened for the presence of antibodies against GM-CSF and IL3 by ELISA and bioassays, using the human erythroleukaemia cell line TF-1. Results: In two of the 32 patients with FS, antibodies to GM-CSF and IL3 were detectable by ELISA. Binding anti-GM-CSF antibodies were also detected in one of the 72 healthy controls, while in another healthy subject and in one of the patients with normocytic RA, anti-IL3 antibodies were present. Serum from one of the two patients with FS who tested positive for anti-IL3 and anti-GM-CSF antibodies by ELISA showed strong neutralising capacity to the biological effect of IL3, but not to GM-CSF in vitro. Patients with FS had significantly higher serum levels of GM-CSF (median; 2.82 pg/mL; interquartile range 2.64–3.19 pg/mL) compared with patients with RA (2.52 pg/mL; 2.28–2.72 pg/mL; p = 0.012) and healthy controls (2.23 pg/mL; 2.04–2.52; p<0.001). In addition, serum levels of IL3 in patients were significantly higher in FS (10.05 pg/mL; 8.94–11.98) compared with controls (4.79 pg/mL; 3.72–7.22; p<0.001), but not compared with RA patients (9.52 pg/mL; 8.32–10.42; p = 0.17). Conclusions: Antibodies to GM-CSF and IL3 are rare in patients with FS and RA and in healthy subjects. In individual patients with FS, the presence of neutralising anti-IL3 antibodies may contribute to the development of cytopenia." @default.
• W2168157584 created "2016-06-24" @default.
• W2168157584 creator A5002173493 @default.
• W2168157584 creator A5036967075 @default.
• W2168157584 creator A5079593789 @default.
• W2168157584 creator A5085617282 @default.
• W2168157584 date "2004-07-01" @default.
• W2168157584 modified "2023-10-01" @default.
• W2168157584 title "Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with Felty's syndrome" @default.
• W2168157584 cites W1503959924 @default.
• W2168157584 cites W1568917344 @default.
• W2168157584 cites W157857262 @default.
• W2168157584 cites W1973699988 @default.
• W2168157584 cites W1986007337 @default.
• W2168157584 cites W2002459830 @default.
• W2168157584 cites W2014576433 @default.
• W2168157584 cites W2016458865 @default.
• W2168157584 cites W2024395135 @default.
• W2168157584 cites W2030994743 @default.
• W2168157584 cites W2046793800 @default.
• W2168157584 cites W2051206141 @default.
• W2168157584 cites W2062891125 @default.
• W2168157584 cites W2076823426 @default.
• W2168157584 cites W2077634266 @default.
• W2168157584 cites W2086437884 @default.
• W2168157584 cites W2101033273 @default.
• W2168157584 cites W2116622733 @default.
• W2168157584 cites W2133305327 @default.
• W2168157584 cites W2152348310 @default.
• W2168157584 cites W2410752766 @default.
• W2168157584 cites W2473496047 @default.
• W2168157584 cites W27505663 @default.
• W2168157584 cites W277141492 @default.
• W2168157584 cites W4237777218 @default.
• W2168157584 cites W78271696 @default.
• W2168157584 cites W859299 @default.
• W2168157584 doi "https://doi.org/10.1136/ard.2003.011056" @default.
• W2168157584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1755075" @default.
• W2168157584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15194585" @default.
• W2168157584 hasPublicationYear "2004" @default.
• W2168157584 type Work @default.
• W2168157584 sameAs 2168157584 @default.
• W2168157584 citedByCount "13" @default.
• W2168157584 countsByYear W21681575842012 @default.
• W2168157584 countsByYear W21681575842015 @default.
• W2168157584 countsByYear W21681575842016 @default.
• W2168157584 countsByYear W21681575842023 @default.
• W2168157584 crossrefType "journal-article" @default.
• W2168157584 hasAuthorship W2168157584A5002173493 @default.
• W2168157584 hasAuthorship W2168157584A5036967075 @default.
• W2168157584 hasAuthorship W2168157584A5079593789 @default.
• W2168157584 hasAuthorship W2168157584A5085617282 @default.
• W2168157584 hasBestOaLocation W21681575841 @default.
• W2168157584 hasConcept C126322002 @default.
• W2168157584 hasConcept C159654299 @default.
• W2168157584 hasConcept C163764329 @default.
• W2168157584 hasConcept C203014093 @default.
• W2168157584 hasConcept C2776694085 @default.
• W2168157584 hasConcept C2777063308 @default.
• W2168157584 hasConcept C2777478134 @default.
• W2168157584 hasConcept C2777575956 @default.
• W2168157584 hasConcept C2778491709 @default.
• W2168157584 hasConcept C2778690821 @default.
• W2168157584 hasConcept C71924100 @default.
• W2168157584 hasConcept C90924648 @default.
• W2168157584 hasConceptScore W2168157584C126322002 @default.
• W2168157584 hasConceptScore W2168157584C159654299 @default.
• W2168157584 hasConceptScore W2168157584C163764329 @default.
• W2168157584 hasConceptScore W2168157584C203014093 @default.
• W2168157584 hasConceptScore W2168157584C2776694085 @default.
• W2168157584 hasConceptScore W2168157584C2777063308 @default.
• W2168157584 hasConceptScore W2168157584C2777478134 @default.
• W2168157584 hasConceptScore W2168157584C2777575956 @default.
• W2168157584 hasConceptScore W2168157584C2778491709 @default.
• W2168157584 hasConceptScore W2168157584C2778690821 @default.
• W2168157584 hasConceptScore W2168157584C71924100 @default.
• W2168157584 hasConceptScore W2168157584C90924648 @default.
• W2168157584 hasIssue "7" @default.
• W2168157584 hasLocation W21681575841 @default.
• W2168157584 hasLocation W21681575842 @default.
• W2168157584 hasLocation W21681575843 @default.
• W2168157584 hasLocation W21681575844 @default.
• W2168157584 hasLocation W21681575845 @default.
• W2168157584 hasOpenAccess W2168157584 @default.
• W2168157584 hasPrimaryLocation W21681575841 @default.
• W2168157584 hasRelatedWork W2017027775 @default.
• W2168157584 hasRelatedWork W2101875571 @default.
• W2168157584 hasRelatedWork W2156283049 @default.
• W2168157584 hasRelatedWork W2316954211 @default.
• W2168157584 hasRelatedWork W2411146163 @default.
• W2168157584 hasRelatedWork W2425255793 @default.
• W2168157584 hasRelatedWork W2427075784 @default.
• W2168157584 hasRelatedWork W2761967325 @default.
• W2168157584 hasRelatedWork W4232149484 @default.
• W2168157584 hasRelatedWork W4233809360 @default.
• W2168157584 hasVolume "63" @default.
• W2168157584 isParatext "false" @default.
• W2168157584 isRetracted "false" @default.

• next