FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168168388> ?p ?o ?g. }

• W2168168388 endingPage "102" @default.
• W2168168388 startingPage "91" @default.
• W2168168388 abstract "Intranasal azelastine hydrochloride (Astelin, Meda Pharmaceuticals, Somerset, NJ, USA) is a first-line treatment for allergic and non-allergic vasomotor rhinitis with well-established therapeutic efficacy and safety. A new formulation of azelastine nasal spray (Astepro, Meda Pharmaceuticals, Somerset, NJ, USA), with a sorbitol-based vehicle and sucralose as a taste-masking agent, was developed to reduce the bitter taste of azelastine experienced by some patients.Two studies were conducted to evaluate the safety, tolerability and pharmacokinetic parameters of this new formulation compared with the original azelastine nasal spray.In a pharmacokinetic study, 18 healthy volunteers received either a single dose of the new formulation or the original formulation and pharmacokinetic parameters were determined. In a 1-year safety study, patients with chronic rhinitis were randomized to the new formulation (n = 430) or the original formulation (n = 432) to assess tolerability and the potential for adverse effects on the nasal mucosa.The new formulation was safe and well tolerated with long-term use and had a comparable pharmacokinetic profile to the original formulation. The overall incidence of treatment-emergent adverse events with the new formulation (48.4%) and the original formulation (49.1%) was similar, with no evidence of increased nasal irritation, nasal septal perforation, severe epistaxis or ulceration with either formulation during the 1-year study." @default.
• W2168168388 created "2016-06-24" @default.
• W2168168388 creator A5078829922 @default.
• W2168168388 date "2009-01-01" @default.
• W2168168388 modified "2023-10-15" @default.
• W2168168388 title "Pharmacokinetic characteristics and safety and tolerability of a reformulated azelastine hydrochloride nasal spray in patients with chronic rhinitis" @default.
• W2168168388 cites W180119566 @default.
• W2168168388 cites W18777319 @default.
• W2168168388 cites W1971293075 @default.
• W2168168388 cites W1977034799 @default.
• W2168168388 cites W1990969825 @default.
• W2168168388 cites W2004291103 @default.
• W2168168388 cites W2008955505 @default.
• W2168168388 cites W2011769776 @default.
• W2168168388 cites W2023228660 @default.
• W2168168388 cites W2023262375 @default.
• W2168168388 cites W2025071774 @default.
• W2168168388 cites W2025422535 @default.
• W2168168388 cites W2028204150 @default.
• W2168168388 cites W2030897240 @default.
• W2168168388 cites W2036540489 @default.
• W2168168388 cites W2039415856 @default.
• W2168168388 cites W2042573566 @default.
• W2168168388 cites W2062061217 @default.
• W2168168388 cites W2063390971 @default.
• W2168168388 cites W2065118186 @default.
• W2168168388 cites W2066354923 @default.
• W2168168388 cites W2068926397 @default.
• W2168168388 cites W2079047143 @default.
• W2168168388 cites W2079984901 @default.
• W2168168388 cites W2080356144 @default.
• W2168168388 cites W2084304346 @default.
• W2168168388 cites W2086167722 @default.
• W2168168388 cites W2094201276 @default.
• W2168168388 cites W2102161193 @default.
• W2168168388 cites W2131864493 @default.
• W2168168388 cites W2143924168 @default.
• W2168168388 doi "https://doi.org/10.1517/17425250802670474" @default.
• W2168168388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19220164" @default.
• W2168168388 hasPublicationYear "2009" @default.
• W2168168388 type Work @default.
• W2168168388 sameAs 2168168388 @default.
• W2168168388 citedByCount "15" @default.
• W2168168388 countsByYear W21681683882012 @default.
• W2168168388 countsByYear W21681683882016 @default.
• W2168168388 countsByYear W21681683882019 @default.
• W2168168388 countsByYear W21681683882020 @default.
• W2168168388 countsByYear W21681683882021 @default.
• W2168168388 countsByYear W21681683882022 @default.
• W2168168388 crossrefType "journal-article" @default.
• W2168168388 hasAuthorship W2168168388A5078829922 @default.
• W2168168388 hasConcept C112705442 @default.
• W2168168388 hasConcept C16005928 @default.
• W2168168388 hasConcept C197934379 @default.
• W2168168388 hasConcept C2778375690 @default.
• W2168168388 hasConcept C2778984665 @default.
• W2168168388 hasConcept C2779121184 @default.
• W2168168388 hasConcept C2779777004 @default.
• W2168168388 hasConcept C2780113039 @default.
• W2168168388 hasConcept C2780973058 @default.
• W2168168388 hasConcept C2910477827 @default.
• W2168168388 hasConcept C42219234 @default.
• W2168168388 hasConcept C42404028 @default.
• W2168168388 hasConcept C46821324 @default.
• W2168168388 hasConcept C71924100 @default.
• W2168168388 hasConcept C85663871 @default.
• W2168168388 hasConcept C98274493 @default.
• W2168168388 hasConceptScore W2168168388C112705442 @default.
• W2168168388 hasConceptScore W2168168388C16005928 @default.
• W2168168388 hasConceptScore W2168168388C197934379 @default.
• W2168168388 hasConceptScore W2168168388C2778375690 @default.
• W2168168388 hasConceptScore W2168168388C2778984665 @default.
• W2168168388 hasConceptScore W2168168388C2779121184 @default.
• W2168168388 hasConceptScore W2168168388C2779777004 @default.
• W2168168388 hasConceptScore W2168168388C2780113039 @default.
• W2168168388 hasConceptScore W2168168388C2780973058 @default.
• W2168168388 hasConceptScore W2168168388C2910477827 @default.
• W2168168388 hasConceptScore W2168168388C42219234 @default.
• W2168168388 hasConceptScore W2168168388C42404028 @default.
• W2168168388 hasConceptScore W2168168388C46821324 @default.
• W2168168388 hasConceptScore W2168168388C71924100 @default.
• W2168168388 hasConceptScore W2168168388C85663871 @default.
• W2168168388 hasConceptScore W2168168388C98274493 @default.
• W2168168388 hasIssue "1" @default.
• W2168168388 hasLocation W21681683881 @default.
• W2168168388 hasLocation W21681683882 @default.
• W2168168388 hasOpenAccess W2168168388 @default.
• W2168168388 hasPrimaryLocation W21681683881 @default.
• W2168168388 hasRelatedWork W1807078522 @default.
• W2168168388 hasRelatedWork W1974998611 @default.
• W2168168388 hasRelatedWork W1988456554 @default.
• W2168168388 hasRelatedWork W1989718697 @default.
• W2168168388 hasRelatedWork W2004291103 @default.
• W2168168388 hasRelatedWork W2076100225 @default.
• W2168168388 hasRelatedWork W2079554523 @default.
• W2168168388 hasRelatedWork W2150163190 @default.
• W2168168388 hasRelatedWork W2157370005 @default.
• W2168168388 hasRelatedWork W2587347780 @default.

• next