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• W2168171808 startingPage "283" @default.
• W2168171808 abstract "Increasing evidence shows that the cells associated with atherogenesis (platelets, endothelialand smooth muscle cells, fibroblasts, monocytes, macrophages and T lymphocytes) express proinflammatorypathways of CD40 signalling. Activation of platelets CD40/CD40L system andits counterpart CD40 receptors on vascular cell surface induces the expression of variousadhesion molecules, cytokines, chemokines, growth factors, matrix metalloproteinases andreactive oxygen species, the substances which are responsible for plaque formation,destabilisation and rupture. Disturbed laminar blood flow (low wall shear stress) can mediateCD40/CD40L system signalling by increasing the residence time of the interaction betweenplatelets and endothelium. Experimental studies provide considerable data indicating that interruption of CD40 signallingsignificantly inhibits the progression of established atheroma and altered plaque compositionfor a lipid-poor collagen-rich stable plaque phenotype. Recent data suggest different aspectsof CD40/CD40L system activation in the context of risk factors (hypercholesterolaemia, diabetesmellitus, obesity and cigarette smoking) link them into the pro-inflammatory and prothromboticmilieu, aggravating the atherosclerotic process. Activation of the CD40/CD40Lsystem plays a pivotal role in acute coronary syndromes as well as acute cerebral ischaemia.After percutaneous coronary intervention the risk of restenosis increases with high levels ofplasma-soluble CD40L (sCD40L). In apparently healthy women sCD40L concentration hasbeen recognised as an independent risk factor of the first acute coronary event. Clopidogrel,aspirin, statins and some oral hypoglycaemic agents share common anti-inflammatory propertiesincluding inhibition of CD40/CD40L intercellular signalling. To prevent plaque progression,destabilisation and thrombotic complications, anti-platelet treatment strategy should befocused on inhibition of platelet activation instead of on response to platelet aggregation." @default.
• W2168171808 created "2016-06-24" @default.
• W2168171808 creator A5044229657 @default.
• W2168171808 creator A5063247962 @default.
• W2168171808 date "2006-01-01" @default.
• W2168171808 modified "2023-09-25" @default.
• W2168171808 title "The role of CD40/CD40 ligand system in the pathogenesis of atherosclerosis" @default.
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