Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168223575> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2168223575 endingPage "1030" @default.
- W2168223575 startingPage "1025" @default.
- W2168223575 abstract "Endogenous interleukin (IL)-12 plays a pivotal role in promoting cell-mediated immunity against intracellular pathogens. Uncontrolled cell-mediated immune responses, however, may lead to chronic inflammation and autoimmune disease. Unfortunately, treatment of either infection or autoimmunity with immunomodulating drugs always incur the danger of favouring the other form of disease. The recent discovery of the dimeric IL-12-related cytokine IL-23 adds to our understanding of the fine tuning of cellular immunity. Only recently, studies revealed IL-23, and not IL-12, to be the decisive factor in this immune deviation and a variety of autoimmune disorders have now been shown to be strikingly dependent on IL-23. Therefore, targeting of IL-23-mediated, rather than IL-12-dependent, mechanisms represent a promising therapeutic approach for autoimmune diseases. The invention of aptamers that are capable of neutralising IL-23 and/or IL-12 and their potential use as autoimmune disease therapeutics will be discussed." @default.
- W2168223575 created "2016-06-24" @default.
- W2168223575 creator A5080381047 @default.
- W2168223575 date "2006-06-21" @default.
- W2168223575 modified "2023-09-25" @default.
- W2168223575 title "Aptamers against interleukin-12-related cytokines as novel therapeutics in autoimmune diseases" @default.
- W2168223575 cites W1585477246 @default.
- W2168223575 cites W1627771650 @default.
- W2168223575 cites W1847326477 @default.
- W2168223575 cites W1970847994 @default.
- W2168223575 cites W1987628377 @default.
- W2168223575 cites W2006249161 @default.
- W2168223575 cites W2011790158 @default.
- W2168223575 cites W2038535814 @default.
- W2168223575 cites W2050753578 @default.
- W2168223575 cites W2070837122 @default.
- W2168223575 cites W2076889715 @default.
- W2168223575 cites W2087905758 @default.
- W2168223575 cites W2088654830 @default.
- W2168223575 cites W2107235439 @default.
- W2168223575 cites W2112434543 @default.
- W2168223575 cites W2115855176 @default.
- W2168223575 cites W2116828514 @default.
- W2168223575 cites W2133282256 @default.
- W2168223575 cites W2133657961 @default.
- W2168223575 cites W2136357996 @default.
- W2168223575 cites W2141679700 @default.
- W2168223575 cites W2147329812 @default.
- W2168223575 doi "https://doi.org/10.1517/13543776.16.7.1025" @default.
- W2168223575 hasPublicationYear "2006" @default.
- W2168223575 type Work @default.
- W2168223575 sameAs 2168223575 @default.
- W2168223575 citedByCount "0" @default.
- W2168223575 crossrefType "journal-article" @default.
- W2168223575 hasAuthorship W2168223575A5080381047 @default.
- W2168223575 hasConcept C142724271 @default.
- W2168223575 hasConcept C159654299 @default.
- W2168223575 hasConcept C203014093 @default.
- W2168223575 hasConcept C2776914184 @default.
- W2168223575 hasConcept C2778690821 @default.
- W2168223575 hasConcept C2779075594 @default.
- W2168223575 hasConcept C2779134260 @default.
- W2168223575 hasConcept C2779341262 @default.
- W2168223575 hasConcept C2780130043 @default.
- W2168223575 hasConcept C71924100 @default.
- W2168223575 hasConcept C74172505 @default.
- W2168223575 hasConcept C86803240 @default.
- W2168223575 hasConcept C8891405 @default.
- W2168223575 hasConceptScore W2168223575C142724271 @default.
- W2168223575 hasConceptScore W2168223575C159654299 @default.
- W2168223575 hasConceptScore W2168223575C203014093 @default.
- W2168223575 hasConceptScore W2168223575C2776914184 @default.
- W2168223575 hasConceptScore W2168223575C2778690821 @default.
- W2168223575 hasConceptScore W2168223575C2779075594 @default.
- W2168223575 hasConceptScore W2168223575C2779134260 @default.
- W2168223575 hasConceptScore W2168223575C2779341262 @default.
- W2168223575 hasConceptScore W2168223575C2780130043 @default.
- W2168223575 hasConceptScore W2168223575C71924100 @default.
- W2168223575 hasConceptScore W2168223575C74172505 @default.
- W2168223575 hasConceptScore W2168223575C86803240 @default.
- W2168223575 hasConceptScore W2168223575C8891405 @default.
- W2168223575 hasIssue "7" @default.
- W2168223575 hasLocation W21682235751 @default.
- W2168223575 hasOpenAccess W2168223575 @default.
- W2168223575 hasPrimaryLocation W21682235751 @default.
- W2168223575 hasRelatedWork W1568581857 @default.
- W2168223575 hasRelatedWork W2047765480 @default.
- W2168223575 hasRelatedWork W2096287500 @default.
- W2168223575 hasRelatedWork W2164219360 @default.
- W2168223575 hasRelatedWork W2223869382 @default.
- W2168223575 hasRelatedWork W2593968410 @default.
- W2168223575 hasRelatedWork W3185323772 @default.
- W2168223575 hasRelatedWork W4210976760 @default.
- W2168223575 hasRelatedWork W4285095339 @default.
- W2168223575 hasRelatedWork W4311075666 @default.
- W2168223575 hasVolume "16" @default.
- W2168223575 isParatext "false" @default.
- W2168223575 isRetracted "false" @default.
- W2168223575 magId "2168223575" @default.
- W2168223575 workType "article" @default.