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• W2168224930 abstract "The androgen receptor (AR) plays a key role in prostate cancer development, as well as its treatments, even for the hormone-refractory state. Here, we report that an earlier described lysine-to-arginine mutation at position 179 in AR leads to a more potent AR. We show that two activation domains (Tau-1 and Tau-5) are necessary and sufficient for the full activity of AR and the intrinsic activity of the AR-NTD. Two alpha-helices surrounding the Lys179 define the core of Tau-1, which can act as an autonomous activation function, independent of p160 coactivators. Furthermore, we show that although the recruitment of p160 coactivators is mediated through Tau-5, this event is attenuated by core Tau-1. This better definition of the mechanisms of action of both Tau-1 and Tau-5 is instrumental for the design of alternative therapeutic strategies against prostate cancer." @default.
• W2168224930 created "2016-06-24" @default.
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• W2168224930 date "2006-01-01" @default.
• W2168224930 modified "2023-10-12" @default.
• W2168224930 title "Interplay between Two Hormone-Independent Activation Domains in the Androgen Receptor" @default.
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• W2168224930 doi "https://doi.org/10.1158/0008-5472.can-05-2389" @default.
• W2168224930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16397271" @default.
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