FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168240907> ?p ?o ?g. }

• W2168240907 endingPage "1558" @default.
• W2168240907 startingPage "1553" @default.
• W2168240907 abstract "PURPOSE A single-center retrospective analysis was conducted in 167 patients with Waldenström's macroglobulinemia (WM) to delineate prognostic factors. PATIENTS AND METHODS One hundred sixty-seven patients diagnosed between January 1969 and December 1988, fulfilling diagnostic criteria of WM, were entered onto this study. One hundred twenty-eight patients were treated with chlorambucil (0.1 mg/kg/d): 117 at diagnosis and 11 during the disease course. Seventeen variables were analyzed in all patients and in treated patients for their prognostic value on survival using the Kaplan-Meier method and a Cox multivariate regression analysis. RESULTS Median survival duration for all patients was 60 months. Pretreatment factors associated with shorter survival in the entire population were age > or = 60 years (P = .006), male sex (P = .0001), general symptoms (P = .01), hemoglobin less than 10 g/dL (P = .008), leukocytes less than 4 X 10(9)/L (P = .02), neutrophils less than 1.7 X 10(9)/L (P = .02), and platelets less than 150 X 10(9)/L (P = .0006). Organomegaly, signs of hyperviscosity, renal failure, monoclonal immunoglobulin M (M IgM) level, blood lymphocytosis, and percentage of marrow lymphoid cells were not significantly correlated with survival. In a Cox multivariate regression analysis, the combination of factors that gave the best prognostic value was the association of sex (P = .0002), neutrophils (P = .002), age (P = .008), and hemoglobin (P = .02). CONCLUSION Our findings suggest that some pretreatment parameters, including older age, male sex, general symptoms, and cytopenias, carry a poor prognosis in WM. By contrast, high initial tumor burden (indicated by organomegaly, high IgM level, and high percentage of marrow lymphoid cells) does not seem to be significantly associated with short survival. Our results help define a high-risk population that could perhaps benefit from newer therapeutic approaches." @default.
• W2168240907 created "2016-06-24" @default.
• W2168240907 creator A5005205127 @default.
• W2168240907 creator A5009368373 @default.
• W2168240907 creator A5014838075 @default.
• W2168240907 creator A5024315315 @default.
• W2168240907 creator A5050330963 @default.
• W2168240907 creator A5070617775 @default.
• W2168240907 creator A5076627885 @default.
• W2168240907 creator A5087659468 @default.
• W2168240907 date "1993-08-01" @default.
• W2168240907 modified "2023-10-18" @default.
• W2168240907 title "Prognostic factors in Waldenström's macroglobulinemia: a report of 167 cases." @default.
• W2168240907 cites W137878760 @default.
• W2168240907 cites W1484424479 @default.
• W2168240907 cites W1502953431 @default.
• W2168240907 cites W1580788756 @default.
• W2168240907 cites W1814490572 @default.
• W2168240907 cites W1828420111 @default.
• W2168240907 cites W1888632689 @default.
• W2168240907 cites W1974885851 @default.
• W2168240907 cites W1979300931 @default.
• W2168240907 cites W1983066514 @default.
• W2168240907 cites W1994273437 @default.
• W2168240907 cites W1996022438 @default.
• W2168240907 cites W199964741 @default.
• W2168240907 cites W2021890117 @default.
• W2168240907 cites W2187668060 @default.
• W2168240907 cites W2319233995 @default.
• W2168240907 cites W2440452359 @default.
• W2168240907 doi "https://doi.org/10.1200/jco.1993.11.8.1553" @default.
• W2168240907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8336194" @default.
• W2168240907 hasPublicationYear "1993" @default.
• W2168240907 type Work @default.
• W2168240907 sameAs 2168240907 @default.
• W2168240907 citedByCount "149" @default.
• W2168240907 countsByYear W21682409072012 @default.
• W2168240907 countsByYear W21682409072013 @default.
• W2168240907 countsByYear W21682409072014 @default.
• W2168240907 countsByYear W21682409072016 @default.
• W2168240907 countsByYear W21682409072017 @default.
• W2168240907 countsByYear W21682409072018 @default.
• W2168240907 countsByYear W21682409072019 @default.
• W2168240907 countsByYear W21682409072020 @default.
• W2168240907 countsByYear W21682409072022 @default.
• W2168240907 countsByYear W21682409072023 @default.
• W2168240907 crossrefType "journal-article" @default.
• W2168240907 hasAuthorship W2168240907A5005205127 @default.
• W2168240907 hasAuthorship W2168240907A5009368373 @default.
• W2168240907 hasAuthorship W2168240907A5014838075 @default.
• W2168240907 hasAuthorship W2168240907A5024315315 @default.
• W2168240907 hasAuthorship W2168240907A5050330963 @default.
• W2168240907 hasAuthorship W2168240907A5070617775 @default.
• W2168240907 hasAuthorship W2168240907A5076627885 @default.
• W2168240907 hasAuthorship W2168240907A5087659468 @default.
• W2168240907 hasConcept C126322002 @default.
• W2168240907 hasConcept C2776364478 @default.
• W2168240907 hasConcept C2776391228 @default.
• W2168240907 hasConcept C2776694085 @default.
• W2168240907 hasConcept C2776755627 @default.
• W2168240907 hasConcept C2777866208 @default.
• W2168240907 hasConcept C2778551932 @default.
• W2168240907 hasConcept C2779134260 @default.
• W2168240907 hasConcept C2779338263 @default.
• W2168240907 hasConcept C2780126324 @default.
• W2168240907 hasConcept C2781038049 @default.
• W2168240907 hasConcept C2908647359 @default.
• W2168240907 hasConcept C38180746 @default.
• W2168240907 hasConcept C50382708 @default.
• W2168240907 hasConcept C71924100 @default.
• W2168240907 hasConcept C90924648 @default.
• W2168240907 hasConcept C99454951 @default.
• W2168240907 hasConceptScore W2168240907C126322002 @default.
• W2168240907 hasConceptScore W2168240907C2776364478 @default.
• W2168240907 hasConceptScore W2168240907C2776391228 @default.
• W2168240907 hasConceptScore W2168240907C2776694085 @default.
• W2168240907 hasConceptScore W2168240907C2776755627 @default.
• W2168240907 hasConceptScore W2168240907C2777866208 @default.
• W2168240907 hasConceptScore W2168240907C2778551932 @default.
• W2168240907 hasConceptScore W2168240907C2779134260 @default.
• W2168240907 hasConceptScore W2168240907C2779338263 @default.
• W2168240907 hasConceptScore W2168240907C2780126324 @default.
• W2168240907 hasConceptScore W2168240907C2781038049 @default.
• W2168240907 hasConceptScore W2168240907C2908647359 @default.
• W2168240907 hasConceptScore W2168240907C38180746 @default.
• W2168240907 hasConceptScore W2168240907C50382708 @default.
• W2168240907 hasConceptScore W2168240907C71924100 @default.
• W2168240907 hasConceptScore W2168240907C90924648 @default.
• W2168240907 hasConceptScore W2168240907C99454951 @default.
• W2168240907 hasIssue "8" @default.
• W2168240907 hasLocation W21682409071 @default.
• W2168240907 hasLocation W21682409072 @default.
• W2168240907 hasOpenAccess W2168240907 @default.
• W2168240907 hasPrimaryLocation W21682409071 @default.
• W2168240907 hasRelatedWork W1989752474 @default.
• W2168240907 hasRelatedWork W2016750812 @default.
• W2168240907 hasRelatedWork W2042301613 @default.
• W2168240907 hasRelatedWork W2047466514 @default.

• next