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- W2168256727 abstract "Abstract Protective responses in mice immunized with an interferon-gamma producing strain of Cryptococcus neoformans , H99γ, are associated with IL-17A production by neutrophils. Neutrophil depletion in H99γ-immunized mice did not affect pulmonary fungal burden, indicating that neutrophils are not required for clearance. However, we observed an increase in IL-17A in the lungs of neutrophil-depleted H99γ infected mice, which corresponded to an increase in IL-17A + γδ + T cells. Moreover, we observed increased IL-17A + / CD3 + cells and IL-17A + /γδ + cells, but decreased IL-17A + /Ly6G + neutrophils in the lungs of IL-17 receptor (R)A deficient mice compared to wild-type mice. Increased production of IL-17A in neutropenic mice coincided with increased IL-6 and CXCL1, but not Th17 inducing cytokines TGF-β, IL-21 and IL-23. Concurrent depletion of neutrophils and γδ + T cells reduced IL-17A levels. Our results suggest that γδ + T cells mediate significant IL-17A production in neutropenic mice during the protective response to C . neoformans infection." @default.
- W2168256727 created "2016-06-24" @default.
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- W2168256727 date "2012-12-01" @default.
- W2168256727 modified "2023-10-10" @default.
- W2168256727 title "Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by gamma/delta T cells" @default.
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- W2168256727 doi "https://doi.org/10.1186/1471-2172-13-65" @default.
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