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• W2168263399 abstract "Nucleoside analogues with a Z- or an E-methylenecyclopropane moiety were synthesized and examined for activity against human immunodeficiency virus type 1 (HIV-1) in vitro. The addition of a methyl phenyl phosphoro-L-alaninate moiety to modestly active analogues resulted in potentiation of their anti-HIV-1 activity. Two such compounds, designated QYL-685 (with 2,6-diaminopurine) and QYL-609 (with adenine), were most potent against HIV-1 in vitro, with 50% inhibitory concentrations of 0.034 and 0.0026 microM, respectively, in MT-2 cell-based assays. Both compounds were active against zidovudine-resistant, didanosine-resistant, and multi-dideoxynucleoside-resistant infectious clones in vitro. Further development of these analogues as potential therapies for HIV-1 infection is warranted." @default.
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• W2168263399 date "1999-06-01" @default.
• W2168263399 modified "2023-10-12" @default.
• W2168263399 title "In Vitro Anti-Human Immunodeficiency Virus Activities of <i>Z</i> - and <i>E</i> -Methylenecyclopropane Nucleoside Analogues and Their Phosphoro- <scp>l</scp> -Alaninate Diesters" @default.
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• W2168263399 doi "https://doi.org/10.1128/aac.43.6.1487" @default.
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