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- W2168277572 abstract "The development of germ cell carcinoma of the ovary during pregnancy is a rare occurrence. Recent advances in chemotherapy have improved significantly the prognosis for patients with early stage disease. Use of cytotoxic agents in pregnancy traditionally has been avoided because of possible teratogenic effects. We describe a pregnant patient who was found to have endodermal sinus tumor of the ovary, stage I, at 13 weeks gestation. She received five courses of adjuvant VAC chemotherapy, beginning with her 17th week of gestation, prior to delivery of a normal infant at term. After an additional seven courses of chemotherapy, a second-look laparotomy revealed no evidence of disease. The infant is developmentally normal at 1 year. A comprehensive review of the literature describing use of chemotherapeutic agents in pregnancy is presented." @default.
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- W2168277572 date "1989-03-01" @default.
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- W2168277572 title "Adjuvant chemotherapy in a pregnant patient with endodermal sinus tumor of the ovary" @default.
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- W2168277572 doi "https://doi.org/10.1016/0090-8258(89)90644-6" @default.
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