Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168283792> ?p ?o ?g. }
- W2168283792 abstract "To elucidate in vitro the transience of glucagon-induced hepatic glucose release, the effects of glucagon on hepatic glucose production and cAMP release were evaluated in the isolated rat liver preparation perfused by a nonrecirculating system. Glucagon was added to the infusate in stepwise increasing concentrations at 0, 60, and 100 min to give final concentrations of 2.5 X 10(-11), 10(-9), and 5 X 10(-8) M, respectively. Glucagon at 2.5 X 10(-11) M caused cAMP release [basal (mean +/- SD), 11.2 +/- 3.0 pmol/(min X 100 g BW)] to rise rapidly and plateau at 23.3 +/- 7.0 pmol/(min X 100 g BW), whereas hepatic glucose production [basal, 3.7 +/- 1.6 mumol/(min X 100 g BW)] increased only transiently to a maximum of 15.3 +/- 3.1 mumol/(min X 100 g BW) and fell thereafter. The enhanced cAMP release during the consecutive glucagon infusion was accompanied by a transient rise in hepatic glucose production during the second, but not during a third, glucagon infusion. When 3-isobutyl-1-methylxanthine, a potent phosphodiesterase inhibitor, was added to the perfusion medium (0.5 mM), the cAMP response to 2.5 X 10(-11) M glucagon was enhanced [247 +/- 124 pmol/(min X 100 g BW)] as was hepatic glucose production (+ 21%; P less than 0.05). Further augmentation of the glucagon concentration was followed by an increase in hepatic cAMP, but not glucose, release. When glucagon infusion (2.5 X 10(-11) M) was repeated with a glucagon-free period of 30 min in between, no stimulation of cAMP and consecutive glucose release was found during the second period. However, when the second glucagon dose was increased to 10(-9) M, glucose and cAMP release were again stimulated to the same extent as in experiments with no glucagon-free period in between. We conclude that the size of the glycogen pool and the cAMP concentration directly modulate hepatic glucose production and are responsible for evanescent glucagon action. This mechanism can be described by computer simulation." @default.
- W2168283792 created "2016-06-24" @default.
- W2168283792 creator A5012165137 @default.
- W2168283792 creator A5038773949 @default.
- W2168283792 creator A5049558583 @default.
- W2168283792 creator A5078001608 @default.
- W2168283792 creator A5078743062 @default.
- W2168283792 creator A5082957801 @default.
- W2168283792 creator A5088153148 @default.
- W2168283792 date "1985-03-01" @default.
- W2168283792 modified "2023-09-25" @default.
- W2168283792 title "Contribution by the Glycogen Pool and Adenosine 3′,5′ Monophosphate Release to the Evanescent Effect of Glucagon on Hepatic Glucose Productionin Vitro*" @default.
- W2168283792 cites W1499316111 @default.
- W2168283792 cites W1525562492 @default.
- W2168283792 cites W1578458937 @default.
- W2168283792 cites W1582996069 @default.
- W2168283792 cites W1588148271 @default.
- W2168283792 cites W1588593248 @default.
- W2168283792 cites W1603557977 @default.
- W2168283792 cites W1603836262 @default.
- W2168283792 cites W1608569838 @default.
- W2168283792 cites W1667518818 @default.
- W2168283792 cites W1855195526 @default.
- W2168283792 cites W1966211513 @default.
- W2168283792 cites W1972591967 @default.
- W2168283792 cites W1984224264 @default.
- W2168283792 cites W2006103366 @default.
- W2168283792 cites W2011779677 @default.
- W2168283792 cites W2029164149 @default.
- W2168283792 cites W2037933253 @default.
- W2168283792 cites W2043047593 @default.
- W2168283792 cites W2077844789 @default.
- W2168283792 cites W2078452457 @default.
- W2168283792 cites W2092283677 @default.
- W2168283792 cites W2112918293 @default.
- W2168283792 cites W2116412594 @default.
- W2168283792 cites W2138446078 @default.
- W2168283792 cites W2261532043 @default.
- W2168283792 cites W2339175250 @default.
- W2168283792 cites W2397190364 @default.
- W2168283792 cites W2410947620 @default.
- W2168283792 cites W2412818700 @default.
- W2168283792 cites W2464322821 @default.
- W2168283792 doi "https://doi.org/10.1210/endo-116-3-978" @default.
- W2168283792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2578952" @default.
- W2168283792 hasPublicationYear "1985" @default.
- W2168283792 type Work @default.
- W2168283792 sameAs 2168283792 @default.
- W2168283792 citedByCount "17" @default.
- W2168283792 countsByYear W21682837922012 @default.
- W2168283792 crossrefType "journal-article" @default.
- W2168283792 hasAuthorship W2168283792A5012165137 @default.
- W2168283792 hasAuthorship W2168283792A5038773949 @default.
- W2168283792 hasAuthorship W2168283792A5049558583 @default.
- W2168283792 hasAuthorship W2168283792A5078001608 @default.
- W2168283792 hasAuthorship W2168283792A5078743062 @default.
- W2168283792 hasAuthorship W2168283792A5082957801 @default.
- W2168283792 hasAuthorship W2168283792A5088153148 @default.
- W2168283792 hasConcept C126322002 @default.
- W2168283792 hasConcept C134018914 @default.
- W2168283792 hasConcept C146957229 @default.
- W2168283792 hasConcept C181199279 @default.
- W2168283792 hasConcept C185592680 @default.
- W2168283792 hasConcept C20904676 @default.
- W2168283792 hasConcept C2776766087 @default.
- W2168283792 hasConcept C2777499176 @default.
- W2168283792 hasConcept C2777949327 @default.
- W2168283792 hasConcept C2778024521 @default.
- W2168283792 hasConcept C2778563252 @default.
- W2168283792 hasConcept C2779306644 @default.
- W2168283792 hasConcept C55493867 @default.
- W2168283792 hasConcept C62231903 @default.
- W2168283792 hasConcept C62826618 @default.
- W2168283792 hasConcept C71924100 @default.
- W2168283792 hasConcept C86803240 @default.
- W2168283792 hasConceptScore W2168283792C126322002 @default.
- W2168283792 hasConceptScore W2168283792C134018914 @default.
- W2168283792 hasConceptScore W2168283792C146957229 @default.
- W2168283792 hasConceptScore W2168283792C181199279 @default.
- W2168283792 hasConceptScore W2168283792C185592680 @default.
- W2168283792 hasConceptScore W2168283792C20904676 @default.
- W2168283792 hasConceptScore W2168283792C2776766087 @default.
- W2168283792 hasConceptScore W2168283792C2777499176 @default.
- W2168283792 hasConceptScore W2168283792C2777949327 @default.
- W2168283792 hasConceptScore W2168283792C2778024521 @default.
- W2168283792 hasConceptScore W2168283792C2778563252 @default.
- W2168283792 hasConceptScore W2168283792C2779306644 @default.
- W2168283792 hasConceptScore W2168283792C55493867 @default.
- W2168283792 hasConceptScore W2168283792C62231903 @default.
- W2168283792 hasConceptScore W2168283792C62826618 @default.
- W2168283792 hasConceptScore W2168283792C71924100 @default.
- W2168283792 hasConceptScore W2168283792C86803240 @default.
- W2168283792 hasLocation W21682837921 @default.
- W2168283792 hasLocation W21682837922 @default.
- W2168283792 hasOpenAccess W2168283792 @default.
- W2168283792 hasPrimaryLocation W21682837921 @default.
- W2168283792 hasRelatedWork W1794360333 @default.
- W2168283792 hasRelatedWork W1998832524 @default.
- W2168283792 hasRelatedWork W2001590341 @default.
- W2168283792 hasRelatedWork W2018315084 @default.