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- W2168290151 abstract "Hyperlipemia is characterized by elevated chylomicron and Sf 10–400 and lowered Sf 3–9 and high density lipoprotein fractions. Chemical analyses suggest that the chylomicron fraction contains very low density lipoproteins of hepatic origin as well as chylomicrons of alimentary origin. The composition and distribution of lipoprotein molecules within Sf 10–400 subfractions (D < 1.005 and D > 1.005) suggests that Sf 10–400 lipoprotein subfractions are not elevated proportionally in all hyperlipemic subjects. Chemical analyses indicate that a constant triglyceride:phospholipid ratio is important in the formation and stability of Sf 10–400 lipoproteins. Atypical lipoproteins with low cholesterol: phospholipid and high fatty acid ester:cholesterol ratios are found in the Sf 3–9 lipoprotein fractions of hyperlipemic subjects. Hyperlipemia is corrected by the administration of insulin to a subject with diabetic acidosis and the administration of linoleate to two subjects with idiopathic hyperlipemia and associated diabetes mellitus. The sequences in serum lipoprotein metabolism in hyperlipemic states are discussed with reference to overproduction and underutilization. The chylomicron fraction is defined operationally and functionally and the relative contribution of alimentary chylomicrons and endogenous lipoproteins to hyperlipemia discussed." @default.
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- W2168290151 date "1961-02-01" @default.
- W2168290151 modified "2023-10-12" @default.
- W2168290151 title "Studies on the Characterization of Human Serum Lipoproteins Separated by Ultracentrifugation in a Density Gradient" @default.
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- W2168290151 doi "https://doi.org/10.1093/ajcn/9.1.41" @default.
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