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• W2168307317 abstract "The authors previously showed that a minority of nucleus accumbens neurons, which show strong cocaine-induced activation of the immediate early gene Fos, are necessary for cocaine-induced psychomotor sensitization. Here they find that these cocaine-activated neurons have increased numbers of silent synapses following cocaine sensitization. Cocaine-induced alterations in synaptic glutamate function in nucleus accumbens are thought to mediate drug-related behaviors such as psychomotor sensitization. However, previous studies have examined global alterations in randomly selected accumbens neurons regardless of their activation state during cocaine-induced behavior. We recently found that a minority of strongly activated Fos-expressing accumbens neurons are necessary for cocaine-induced psychomotor sensitization, whereas the majority of accumbens neurons are less directly involved. We assessed synaptic alterations in these strongly activated accumbens neurons in Fos-GFP mice, which express a fusion protein of Fos and GFP in strongly activated neurons, and compared these alterations with those in surrounding non-activated neurons. Cocaine sensitization produced higher levels of 'silent synapses', which contained functional NMDA receptors and nonfunctional AMPA receptors only in GFP-positive neurons, 6–11 d after sensitization. Thus, distinct synaptic alterations are induced in the most strongly activated accumbens neurons that mediate psychomotor sensitization." @default.
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• W2168307317 date "2012-09-30" @default.
• W2168307317 modified "2023-10-12" @default.
• W2168307317 title "Silent synapses in selectively activated nucleus accumbens neurons following cocaine sensitization" @default.
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• W2168307317 doi "https://doi.org/10.1038/nn.3232" @default.
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