Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168312017> ?p ?o ?g. }
- W2168312017 endingPage "2886" @default.
- W2168312017 startingPage "2880" @default.
- W2168312017 abstract "Lower responsiveness to erythropoiesis-stimulating agents (ESA-R) predicts cardiovascular (CV) events. Whether ESA-R also affects the risk of end-stage renal disease (ESRD) is unknown.We evaluated ESA-R in 194 consecutive chronic kidney disease (CKD) patients, regularly seen in outpatient nephrology clinics, who started erythropoiesis-stimulating agent (ESA) therapy between 2002-06. Exclusion criteria were causes of anaemia other than CKD or recent transfusion. ESA-R was calculated as (Hb1-Hb0)/time/ESA dose (g/dL/month/10 μg/week of ESA). Patients were classified, from lower to higher tertile of ESA-R, as poor, intermediate and good responders. Time to ESRD was the primary outcome.Age was 64±16 years, 48% were male, 34% had diabetes and 32% had CV disease, glomerular filtration rate (GFR) 24±13 mL/min/1.73 m2 and proteinuria 0.6 g/dL (interquartile range 0.2-1.9). First ESA dose was 23.7±10.8 μg/week; haemoglobin (Hb) increased from 9.9±0.8 g/dL to 11.0±1.2 g/dL at first control, obtained after 1.4±0.4 months. These changes corresponded to an ESA-R of 0.37±0.38 g/dL/month/10 μg/week of ESA and tertiles limits were 0.17 and 0.47. Poor responders were younger and had lower GFR and higher proteinuria than intermediate and good responders. During the first 6 months of ESA therapy, poor responders showed lower Hb levels and sustained longer periods of Hb level<11 g/dL. During follow-up (median 3.0 years), 99 patients reached ESRD. At multivariable Cox's analysis, poor responsiveness was associated with higher risk of ESRD (hazard ratio 2.49, 95% confidence interval 1.28-4.84).ESA-R predicts renal prognosis in CKD patients followed in nephrology practice, where ESRD is the predominant outcome and ESA is commonly used at low dose." @default.
- W2168312017 created "2016-06-24" @default.
- W2168312017 creator A5009196186 @default.
- W2168312017 creator A5010126422 @default.
- W2168312017 creator A5015427913 @default.
- W2168312017 creator A5019096846 @default.
- W2168312017 creator A5067035351 @default.
- W2168312017 creator A5076786210 @default.
- W2168312017 creator A5080793108 @default.
- W2168312017 date "2012-02-08" @default.
- W2168312017 modified "2023-10-13" @default.
- W2168312017 title "Hyporesponsiveness to erythropoiesis-stimulating agents and renal survival in non-dialysis CKD patients" @default.
- W2168312017 cites W1990188871 @default.
- W2168312017 cites W1990220461 @default.
- W2168312017 cites W2005973637 @default.
- W2168312017 cites W2009143579 @default.
- W2168312017 cites W2016532897 @default.
- W2168312017 cites W2016632653 @default.
- W2168312017 cites W2026716582 @default.
- W2168312017 cites W2028097446 @default.
- W2168312017 cites W2040421189 @default.
- W2168312017 cites W2046224330 @default.
- W2168312017 cites W2049666202 @default.
- W2168312017 cites W2066192288 @default.
- W2168312017 cites W2070614628 @default.
- W2168312017 cites W2074603087 @default.
- W2168312017 cites W2085943887 @default.
- W2168312017 cites W2088085043 @default.
- W2168312017 cites W2088466196 @default.
- W2168312017 cites W2097586983 @default.
- W2168312017 cites W2100267190 @default.
- W2168312017 cites W2101827523 @default.
- W2168312017 cites W2106114378 @default.
- W2168312017 cites W2115593565 @default.
- W2168312017 cites W2115870410 @default.
- W2168312017 cites W2121664270 @default.
- W2168312017 cites W2132989103 @default.
- W2168312017 cites W2133254081 @default.
- W2168312017 cites W2134389978 @default.
- W2168312017 cites W2134487085 @default.
- W2168312017 cites W2136840691 @default.
- W2168312017 cites W2140188175 @default.
- W2168312017 cites W2148238637 @default.
- W2168312017 cites W2151511116 @default.
- W2168312017 cites W2152947749 @default.
- W2168312017 cites W2161298115 @default.
- W2168312017 cites W2162009787 @default.
- W2168312017 cites W2170328739 @default.
- W2168312017 cites W2334894921 @default.
- W2168312017 cites W4243225397 @default.
- W2168312017 doi "https://doi.org/10.1093/ndt/gfs007" @default.
- W2168312017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22319218" @default.
- W2168312017 hasPublicationYear "2012" @default.
- W2168312017 type Work @default.
- W2168312017 sameAs 2168312017 @default.
- W2168312017 citedByCount "41" @default.
- W2168312017 countsByYear W21683120172013 @default.
- W2168312017 countsByYear W21683120172014 @default.
- W2168312017 countsByYear W21683120172015 @default.
- W2168312017 countsByYear W21683120172016 @default.
- W2168312017 countsByYear W21683120172017 @default.
- W2168312017 countsByYear W21683120172018 @default.
- W2168312017 countsByYear W21683120172019 @default.
- W2168312017 countsByYear W21683120172020 @default.
- W2168312017 countsByYear W21683120172021 @default.
- W2168312017 countsByYear W21683120172022 @default.
- W2168312017 countsByYear W21683120172023 @default.
- W2168312017 crossrefType "journal-article" @default.
- W2168312017 hasAuthorship W2168312017A5009196186 @default.
- W2168312017 hasAuthorship W2168312017A5010126422 @default.
- W2168312017 hasAuthorship W2168312017A5015427913 @default.
- W2168312017 hasAuthorship W2168312017A5019096846 @default.
- W2168312017 hasAuthorship W2168312017A5067035351 @default.
- W2168312017 hasAuthorship W2168312017A5076786210 @default.
- W2168312017 hasAuthorship W2168312017A5080793108 @default.
- W2168312017 hasBestOaLocation W21683120171 @default.
- W2168312017 hasConcept C119060515 @default.
- W2168312017 hasConcept C126322002 @default.
- W2168312017 hasConcept C126894567 @default.
- W2168312017 hasConcept C134018914 @default.
- W2168312017 hasConcept C159641895 @default.
- W2168312017 hasConcept C2778248108 @default.
- W2168312017 hasConcept C2778534260 @default.
- W2168312017 hasConcept C2778653478 @default.
- W2168312017 hasConcept C2779561371 @default.
- W2168312017 hasConcept C2779703530 @default.
- W2168312017 hasConcept C2779978075 @default.
- W2168312017 hasConcept C2780091579 @default.
- W2168312017 hasConcept C54847362 @default.
- W2168312017 hasConcept C71924100 @default.
- W2168312017 hasConcept C90924648 @default.
- W2168312017 hasConceptScore W2168312017C119060515 @default.
- W2168312017 hasConceptScore W2168312017C126322002 @default.
- W2168312017 hasConceptScore W2168312017C126894567 @default.
- W2168312017 hasConceptScore W2168312017C134018914 @default.
- W2168312017 hasConceptScore W2168312017C159641895 @default.
- W2168312017 hasConceptScore W2168312017C2778248108 @default.
- W2168312017 hasConceptScore W2168312017C2778534260 @default.