FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168312833> ?p ?o ?g. }

• W2168312833 endingPage "983" @default.
• W2168312833 startingPage "963" @default.
• W2168312833 abstract "Little is known about the molecular bases underlying the virulence of diffusely adhering Escherichia coli (DAEC) harbouring the Afa/Dr family of adhesins. These adhesins recognize as receptors the GPI-anchored proteins CD55 (decay-accelerating factor, DAF) and CD66e (carcinoembryonic antigen, CEA). CD66e is a member of the CEA-related cell adhesion molecules (CEACAM) family, comprising seven members. We analysed the interactions of Afa/Dr DAEC with the CEACAMs using CEACAM-expressing CHO and HeLa cells. The results demonstrate that only E. coli expressing a subfamily of Afa/Dr adhesins, named here Afa/Dr-I, including Dr, F1845 and AfaE-III adhesins, bound onto CHO cells expressing CEACAM1, CEA or CEACAM6. Whereas all the Afa/Dr adhesins elicit recruitment of CD55 around adhering bacteria, only the Afa/Dr-I subfamily elicits the recruitment of CEACAM1, CEA and CEACAM6. In addition, although CEACAM3 is not recognized as a receptor by the subfamily of Afa/Dr adhesins, it is recruited around bacteria in HeLa cells. The recruited CEACAM1, CEA and CEACAM6 around adhering bacteria resist totally or in part a detergent extraction, whereas the recruited CEACAM3 does not. Finally, the results show that recognition of CEA and CEACAM6, but not CEACAM1, is accompanied by tight attachment to bacteria of cell surface microvilli-like extensions, which are elongated. Moreover, recognition of CEA is accompanied by an activation of the Rho GTPase Cdc42 and by a phosphorylation of ERM, which in turn elicit the observed cell surface microvilli-like extensions." @default.
• W2168312833 created "2016-06-24" @default.
• W2168312833 creator A5018835870 @default.
• W2168312833 creator A5030084632 @default.
• W2168312833 creator A5051760253 @default.
• W2168312833 creator A5079499882 @default.
• W2168312833 creator A5091257602 @default.
• W2168312833 date "2004-04-13" @default.
• W2168312833 modified "2023-10-16" @default.
• W2168312833 title "Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC)" @default.
• W2168312833 cites W1499058114 @default.
• W2168312833 cites W1517168785 @default.
• W2168312833 cites W1564861448 @default.
• W2168312833 cites W1631814726 @default.
• W2168312833 cites W1812884807 @default.
• W2168312833 cites W1845375977 @default.
• W2168312833 cites W1875628381 @default.
• W2168312833 cites W1893716941 @default.
• W2168312833 cites W1909780944 @default.
• W2168312833 cites W1911083648 @default.
• W2168312833 cites W1917629533 @default.
• W2168312833 cites W1921860486 @default.
• W2168312833 cites W1926560524 @default.
• W2168312833 cites W1949099597 @default.
• W2168312833 cites W1950337425 @default.
• W2168312833 cites W1967872455 @default.
• W2168312833 cites W1968082009 @default.
• W2168312833 cites W1969120551 @default.
• W2168312833 cites W1975440687 @default.
• W2168312833 cites W1977513008 @default.
• W2168312833 cites W1979767486 @default.
• W2168312833 cites W1980507393 @default.
• W2168312833 cites W1980657682 @default.
• W2168312833 cites W1983377759 @default.
• W2168312833 cites W1983462117 @default.
• W2168312833 cites W1985292306 @default.
• W2168312833 cites W1986811442 @default.
• W2168312833 cites W1991419403 @default.
• W2168312833 cites W1994772282 @default.
• W2168312833 cites W1994943697 @default.
• W2168312833 cites W1995498107 @default.
• W2168312833 cites W1997181834 @default.
• W2168312833 cites W2000469457 @default.
• W2168312833 cites W2011630686 @default.
• W2168312833 cites W2012416622 @default.
• W2168312833 cites W2015752928 @default.
• W2168312833 cites W2017174657 @default.
• W2168312833 cites W2021751282 @default.
• W2168312833 cites W2037290743 @default.
• W2168312833 cites W2037309942 @default.
• W2168312833 cites W2044172471 @default.
• W2168312833 cites W2049011942 @default.
• W2168312833 cites W2049042542 @default.
• W2168312833 cites W2049630596 @default.
• W2168312833 cites W2054020689 @default.
• W2168312833 cites W2054037411 @default.
• W2168312833 cites W2059192745 @default.
• W2168312833 cites W2065886456 @default.
• W2168312833 cites W2066058356 @default.
• W2168312833 cites W2067874984 @default.
• W2168312833 cites W2069726487 @default.
• W2168312833 cites W2073016526 @default.
• W2168312833 cites W2073878923 @default.
• W2168312833 cites W2076586496 @default.
• W2168312833 cites W2076864491 @default.
• W2168312833 cites W2080510429 @default.
• W2168312833 cites W2081025984 @default.
• W2168312833 cites W2093106488 @default.
• W2168312833 cites W2093126148 @default.
• W2168312833 cites W2096972275 @default.
• W2168312833 cites W2097228260 @default.
• W2168312833 cites W2099593237 @default.
• W2168312833 cites W2100474559 @default.
• W2168312833 cites W2101277439 @default.
• W2168312833 cites W2101333433 @default.
• W2168312833 cites W2103368250 @default.
• W2168312833 cites W2103672698 @default.
• W2168312833 cites W2111128412 @default.
• W2168312833 cites W2111719241 @default.
• W2168312833 cites W2111778006 @default.
• W2168312833 cites W2114730712 @default.
• W2168312833 cites W2117761762 @default.
• W2168312833 cites W2117916079 @default.
• W2168312833 cites W2118151513 @default.
• W2168312833 cites W2118836261 @default.
• W2168312833 cites W2124622016 @default.
• W2168312833 cites W2130076176 @default.
• W2168312833 cites W2133388060 @default.
• W2168312833 cites W2133906658 @default.
• W2168312833 cites W2134547554 @default.
• W2168312833 cites W2135490717 @default.
• W2168312833 cites W2136259733 @default.
• W2168312833 cites W2138533227 @default.
• W2168312833 cites W2140449528 @default.
• W2168312833 cites W2149611157 @default.
• W2168312833 cites W2154346498 @default.
• W2168312833 cites W2157982703 @default.
• W2168312833 cites W2169168170 @default.

• next