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• W2168326064 abstract "ABSTRACT Coupling of the previously characterized β1-and β2-like adrenoceptors in the sea pansy Renilla koellikeri with adenylate cyclase was examined in membrane preparations from this cnidarian. Adenylate cyclase activity was stimulated by several guanine nucleotides, such as GTP, Gpp(NH)p and GTPγS. Fluoride ions and cholera toxin greatly enhanced the enzyme activity, whereas forskolin had no effect on basal or isoproterenol-induced stimulation of the enzyme. The stimulation of adenylate cyclase activity by several β-adrenergic agonists in different parts of the animal reflected a positive coupling with the β2-and β1-like adrenoceptors in autozooid and peduncle tissues, respectively. In addition, isoproterenol-induced stimulation of adenylate cyclase activity was dependent on guanine nucleotides, suggesting coupling mediated by a G protein. The pharmacological profile of various antagonists on isoproterenol-sensitive adenylate cyclase in autozooid and peduncle tissues matched that of previous radioligand binding studies. Isoproterenol-induced stimulation of adenylate cyclase activity in rachidial tissues was partially inhibited by trifluoperazine or (±)CGP12177 and was completely blocked in the presence of both antagonists. This suggests that coupling of the enzyme occurs with β1-and β2-like adrenoceptors, both being present in the rachis. Serotonin and dopamine were also found to stimulate adenylate cyclase activity. Their stimulatory effect was additive to isoproterenol-induced activation, suggesting the presence of dopaminergic and serotonergic receptors in the tissues of the sea pansy. Along with the data presented previously on β-adrenergic binding, this study suggests that elements of receptor-dependent G protein signal transduction originated early in invertebrate evolution." @default.
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• W2168326064 date "1993-09-01" @default.
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• W2168326064 title "Positive Coupling of β-Like Adrenergic Receptors With Adenylate Cyclase In The Cnidarian <i>Renilla Koellikeri</i>" @default.
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• W2168326064 doi "https://doi.org/10.1242/jeb.182.1.131" @default.
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