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- W2168331112 abstract "Background The recurrence rate of chordoma is high, and the prognosis is poor. Methods Differential proteomic analysis was performed on chordomas and adjacent normal tissues, with verification by Western blot. Protein expression was evaluated by immunohistochemistry of 37 chordomas. Association of candidate protein expression with clinical parameters, disease-free survival, and overall survival were analyzed. Results We identified 14 up-regulated and 5 down-regulated proteins in chordomas. Expression of alpha enolase (ENO1), pyruvate kinase M2 (PKM2), and gp96 was higher in recurrences than in primary tumors. Univariate analysis showed that significantly adverse factors for disease-free survival were overexpression of ENO1 and PKM2, involvement of contiguous vertebral levels, and inadequate surgical margin at initial surgery. Inadequate surgical margin without radiotherapy, involvement of contiguous vertebral levels, and cervical spine location were adverse factors for overall survival. By multivariate analysis, independent adverse prognostic factors were inadequate surgical margin and involvement of multiple contiguous vertebral levels for recurrence; upper cervical spine location and involvement of contiguous vertebral levels for tumor-related death. Multivariate analysis failed to show the significance of the proteins. Conclusions Involvements of multiple contiguous vertebral levels and upper cervical spine, rather than overexpression of ENO1, PKM2, or gp96, are independent prognostic indicators for chordomas. J. Surg. Oncol. 2010;102:720–727. © 2010 Wiley-Liss, Inc." @default.
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- W2168331112 date "2010-08-18" @default.
- W2168331112 modified "2023-10-13" @default.
- W2168331112 title "Differential proteomic profiling of chordomas and analysis of prognostic factors" @default.
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- W2168331112 cites W1970135198 @default.
- W2168331112 cites W1971742491 @default.
- W2168331112 cites W1976267153 @default.
- W2168331112 cites W1976273239 @default.
- W2168331112 cites W1978647823 @default.
- W2168331112 cites W1987335665 @default.
- W2168331112 cites W1996293068 @default.
- W2168331112 cites W1998454073 @default.
- W2168331112 cites W2001825144 @default.
- W2168331112 cites W2004331530 @default.
- W2168331112 cites W2005421986 @default.
- W2168331112 cites W2011231668 @default.
- W2168331112 cites W2015207840 @default.
- W2168331112 cites W2015803946 @default.
- W2168331112 cites W2019630916 @default.
- W2168331112 cites W2025596075 @default.
- W2168331112 cites W2028714029 @default.
- W2168331112 cites W2031021626 @default.
- W2168331112 cites W2037468826 @default.
- W2168331112 cites W2039038348 @default.
- W2168331112 cites W2039605009 @default.
- W2168331112 cites W2041119380 @default.
- W2168331112 cites W2041138881 @default.
- W2168331112 cites W2041836429 @default.
- W2168331112 cites W2043021179 @default.
- W2168331112 cites W2044853699 @default.
- W2168331112 cites W2052289283 @default.
- W2168331112 cites W2052628523 @default.
- W2168331112 cites W2057695117 @default.
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- W2168331112 cites W2083704321 @default.
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- W2168331112 doi "https://doi.org/10.1002/jso.21674" @default.
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