FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168374849> ?p ?o ?g. }

• W2168374849 endingPage "4452" @default.
• W2168374849 startingPage "4441" @default.
• W2168374849 abstract "Heterogeneous ribonucleoprotein-K (hnRNP-K) is normally ubiquitinated by HDM2 for proteasome-mediated degradation. Under DNA-damage conditions, hnRNP-K is transiently stabilized and serves as a transcriptional co-activator of p53 for cell-cycle arrest. However, how the stability and function of hnRNP-K is regulated remained unknown. Here, we demonstrated that UV-induced SUMOylation of hnRNP-K prevents its ubiquitination for stabilization. Using SUMOylation-defective mutant and purified SUMOylated hnRNP-K, SUMOylation was shown to reduce hnRNP-K's affinity to HDM2 with an increase in that to p53 for p21-mediated cell-cycle arrest. PIAS3 served as a small ubiquitin-related modifier (SUMO) E3 ligase for hnRNP-K in an ATR-dependent manner. During later periods after UV exposure, however, SENP2 removed SUMO from hnRNP-K for its destabilization and in turn for release from cell-cycle arrest. Consistent with the rise-and-fall of both SUMOylation and stability of hnRNP-K, its ability to interact with PIAS3 was inversely correlated to that with SENP2 during the time course after UV exposure. These findings indicate that SUMO modification plays a crucial role in the control of hnRNP-K's function as a p53 co-activator in response to DNA damage by UV." @default.
• W2168374849 created "2016-06-24" @default.
• W2168374849 creator A5009564247 @default.
• W2168374849 creator A5024215409 @default.
• W2168374849 creator A5029812244 @default.
• W2168374849 creator A5042288960 @default.
• W2168374849 creator A5054958021 @default.
• W2168374849 creator A5055725373 @default.
• W2168374849 creator A5056147025 @default.
• W2168374849 creator A5071827538 @default.
• W2168374849 creator A5083479792 @default.
• W2168374849 date "2012-10-23" @default.
• W2168374849 modified "2023-09-28" @default.
• W2168374849 title "SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage" @default.
• W2168374849 cites W1650797637 @default.
• W2168374849 cites W1963798045 @default.
• W2168374849 cites W1965493433 @default.
• W2168374849 cites W1966163762 @default.
• W2168374849 cites W1967630574 @default.
• W2168374849 cites W1970488978 @default.
• W2168374849 cites W1973480232 @default.
• W2168374849 cites W1975563698 @default.
• W2168374849 cites W1975759427 @default.
• W2168374849 cites W1989643386 @default.
• W2168374849 cites W1991616147 @default.
• W2168374849 cites W1992360356 @default.
• W2168374849 cites W1993180829 @default.
• W2168374849 cites W1993520606 @default.
• W2168374849 cites W2005893109 @default.
• W2168374849 cites W2007897471 @default.
• W2168374849 cites W2007935491 @default.
• W2168374849 cites W2010281502 @default.
• W2168374849 cites W2012053348 @default.
• W2168374849 cites W2012618272 @default.
• W2168374849 cites W2013108773 @default.
• W2168374849 cites W2020151423 @default.
• W2168374849 cites W2025722611 @default.
• W2168374849 cites W2035188342 @default.
• W2168374849 cites W2037233550 @default.
• W2168374849 cites W2039576757 @default.
• W2168374849 cites W2043927273 @default.
• W2168374849 cites W2052433275 @default.
• W2168374849 cites W2054879089 @default.
• W2168374849 cites W2059392163 @default.
• W2168374849 cites W2061130457 @default.
• W2168374849 cites W2063669247 @default.
• W2168374849 cites W2074615071 @default.
• W2168374849 cites W2077436902 @default.
• W2168374849 cites W2082101329 @default.
• W2168374849 cites W2083358720 @default.
• W2168374849 cites W2083622679 @default.
• W2168374849 cites W2084501381 @default.
• W2168374849 cites W2096229285 @default.
• W2168374849 cites W2104902761 @default.
• W2168374849 cites W2105873215 @default.
• W2168374849 cites W2112441454 @default.
• W2168374849 cites W2119301405 @default.
• W2168374849 cites W2121428233 @default.
• W2168374849 cites W2127551600 @default.
• W2168374849 cites W2128252882 @default.
• W2168374849 cites W2130952513 @default.
• W2168374849 cites W2132396299 @default.
• W2168374849 cites W2136128861 @default.
• W2168374849 cites W2136879986 @default.
• W2168374849 cites W2139462220 @default.
• W2168374849 cites W2141238215 @default.
• W2168374849 cites W2152804961 @default.
• W2168374849 cites W2152957900 @default.
• W2168374849 cites W2164467344 @default.
• W2168374849 cites W2170189698 @default.
• W2168374849 cites W90182880 @default.
• W2168374849 cites W95252060 @default.
• W2168374849 doi "https://doi.org/10.1038/emboj.2012.293" @default.
• W2168374849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3512394" @default.
• W2168374849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23092970" @default.
• W2168374849 hasPublicationYear "2012" @default.
• W2168374849 type Work @default.
• W2168374849 sameAs 2168374849 @default.
• W2168374849 citedByCount "70" @default.
• W2168374849 countsByYear W21683748492013 @default.
• W2168374849 countsByYear W21683748492014 @default.
• W2168374849 countsByYear W21683748492015 @default.
• W2168374849 countsByYear W21683748492016 @default.
• W2168374849 countsByYear W21683748492017 @default.
• W2168374849 countsByYear W21683748492018 @default.
• W2168374849 countsByYear W21683748492019 @default.
• W2168374849 countsByYear W21683748492020 @default.
• W2168374849 countsByYear W21683748492021 @default.
• W2168374849 countsByYear W21683748492022 @default.
• W2168374849 countsByYear W21683748492023 @default.
• W2168374849 crossrefType "journal-article" @default.
• W2168374849 hasAuthorship W2168374849A5009564247 @default.
• W2168374849 hasAuthorship W2168374849A5024215409 @default.
• W2168374849 hasAuthorship W2168374849A5029812244 @default.
• W2168374849 hasAuthorship W2168374849A5042288960 @default.
• W2168374849 hasAuthorship W2168374849A5054958021 @default.
• W2168374849 hasAuthorship W2168374849A5055725373 @default.
• W2168374849 hasAuthorship W2168374849A5056147025 @default.

• next