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- W2168391236 endingPage "R24" @default.
- W2168391236 startingPage "R11" @default.
- W2168391236 abstract "Cardiotonic steroids have been used for the past 200 years in the treatment of congestive heart failure. As specific inhibitors of membrane-bound Na + /K + ATPase, they enhance cardiac contractility through increasing myocardial cell calcium concentration in response to the resulting increase in intracellular Na concentration. The half-minimal concentrations of cardiotonic steroids required to inhibit Na + /K + ATPase range from nanomolar to micromolar concentrations. In contrast, the circulating levels of cardiotonic steroids under physiological conditions are in the low picomolar concentration range in healthy subjects, increasing to high picomolar levels under pathophysiological conditions including chronic kidney disease and heart failure. Little is known about the physiological function of low picomolar concentrations of cardiotonic steroids. Recent studies have indicated that physiological concentrations of cardiotonic steroids acutely stimulate the activity of Na + /K + ATPase and activate an intracellular signaling pathway that regulates a variety of intracellular functions including cell growth and hypertrophy. The effects of circulating cardiotonic steroids on renal salt handling and total body sodium homeostasis are unknown. This review will focus on the role of low picomolar concentrations of cardiotonic steroids in renal Na + /K + ATPase activity, cell signaling, and blood pressure regulation." @default.
- W2168391236 created "2016-06-24" @default.
- W2168391236 creator A5021395049 @default.
- W2168391236 date "2014-04-29" @default.
- W2168391236 modified "2023-10-01" @default.
- W2168391236 title "Advances in understanding the role of cardiac glycosides in control of sodium transport in renal tubules" @default.
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