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- W2168392705 abstract "Dengue has become the most important arboviral infection worldwide with more than 30 million cases of dengue fever estimated to occur each year. The need for a dengue vaccine is great and several live attenuated dengue candidate vaccines are proceeding through clinical evaluation. The need to induce a balanced immune response against all four DENV serotypes with a single vaccine has been a challenge for dengue vaccine developers. A live attenuated DENV chimeric vaccine produced by Sanofi Pasteur has recently entered Phase III evaluation in numerous dengue-endemic regions of the world. Viral interference between serotypes contained in live vaccines has required up to three doses of the vaccine be given over a 12-month period of time. For this reason, novel DENV candidate vaccines are being developed with the goal of achieving a protective immune response with an immunization schedule that can be given over the course of a few months. These next-generation candidates include DNA vaccines, recombinant adenovirus vectored vaccines, alphavirus replicons, and sub-unit protein vaccines. Several of these novel candidates will be discussed." @default.
- W2168392705 created "2016-06-24" @default.
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- W2168392705 date "2011-09-26" @default.
- W2168392705 modified "2023-09-27" @default.
- W2168392705 title "Next-Generation Dengue Vaccines: Novel Strategies Currently Under Development" @default.
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- W2168392705 doi "https://doi.org/10.3390/v3101800" @default.
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