FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168430775> ?p ?o ?g. }

• W2168430775 abstract "Abstract Background Influenza is a respiratory disease that seriously threatens human health. In fact, influenza virus itself does not make critical contribution to mortality induced by influenza, but cytokine storm produced by the excessive immune response triggered by the virus can result in inflammatory reaction of lung tissues and fatal lung tissue injury, and thus increase influenza mortality. Therefore, besides antiviral drugs, immunosuppression drugs should also be included in infection treatment. Presentation of the hypothesis Complement is the center of inflammatory reaction. If complement system is over activated, the body will have strong inflammatory reaction or tissue injury, resulting in pathological process. Many studies have proved that, inflammatory injury of lung tissues caused by influenza virus is closely related to complement activation. Therefore, inhibiting complement activation can significantly reduce inflammatory injury in lung tissues. As complement is both a physiological defense and pathological damage medium, systematic inhibition may result in side effects including infection. Therefore, we design targeting complement inhibitors for complement activation sites, i.e. with CR2 as targeting vector, complement inhibitors like CD59 and Crry are targeted to inflammatory sites to specially inhibit the complement activation in local injury, thus local inflammatory reaction is inhibited. Testing the hypothesis CR2-CD59 and CR2-Crry targeting complement inhibitors are fusion-expressed, and their biological activity is examined via in vivo and in vitro tests. CR2 targeting complement inhibitors are used to treat mouse influenza viral pneumonia model, with PBS treatment group as the control. The survival and lung tissue injury of the mice is observed and the effect of CR2 targeting complement inhibitors on pneumonia induced by influenza virus is evaluated. Implications of the hypothesis CR2 targeting complement inhibitors are expected to be ideal drugs for viral pneumonia." @default.
• W2168430775 created "2016-06-24" @default.
• W2168430775 creator A5006428200 @default.
• W2168430775 creator A5009328791 @default.
• W2168430775 creator A5014061069 @default.
• W2168430775 creator A5034430614 @default.
• W2168430775 creator A5039841256 @default.
• W2168430775 creator A5044282595 @default.
• W2168430775 creator A5046552608 @default.
• W2168430775 creator A5046584963 @default.
• W2168430775 creator A5051968927 @default.
• W2168430775 creator A5063647013 @default.
• W2168430775 creator A5066102428 @default.
• W2168430775 creator A5078190224 @default.
• W2168430775 date "2010-02-09" @default.
• W2168430775 modified "2023-10-13" @default.
• W2168430775 title "A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitior" @default.
• W2168430775 cites W121687570 @default.
• W2168430775 cites W1563519254 @default.
• W2168430775 cites W1591044434 @default.
• W2168430775 cites W1964982019 @default.
• W2168430775 cites W1973412798 @default.
• W2168430775 cites W1993728991 @default.
• W2168430775 cites W1999147222 @default.
• W2168430775 cites W2019340566 @default.
• W2168430775 cites W2028117310 @default.
• W2168430775 cites W2030865344 @default.
• W2168430775 cites W2036617125 @default.
• W2168430775 cites W2048013672 @default.
• W2168430775 cites W2049071821 @default.
• W2168430775 cites W2065152876 @default.
• W2168430775 cites W2066747479 @default.
• W2168430775 cites W2073234751 @default.
• W2168430775 cites W2094031027 @default.
• W2168430775 cites W2113038532 @default.
• W2168430775 cites W2138759154 @default.
• W2168430775 cites W2141107197 @default.
• W2168430775 cites W2150659072 @default.
• W2168430775 cites W2170434427 @default.
• W2168430775 cites W4292550103 @default.
• W2168430775 doi "https://doi.org/10.1186/1743-422x-7-30" @default.
• W2168430775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2829536" @default.
• W2168430775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20144216" @default.
• W2168430775 hasPublicationYear "2010" @default.
• W2168430775 type Work @default.
• W2168430775 sameAs 2168430775 @default.
• W2168430775 citedByCount "16" @default.
• W2168430775 countsByYear W21684307752012 @default.
• W2168430775 countsByYear W21684307752013 @default.
• W2168430775 countsByYear W21684307752014 @default.
• W2168430775 countsByYear W21684307752018 @default.
• W2168430775 countsByYear W21684307752019 @default.
• W2168430775 countsByYear W21684307752020 @default.
• W2168430775 countsByYear W21684307752022 @default.
• W2168430775 crossrefType "journal-article" @default.
• W2168430775 hasAuthorship W2168430775A5006428200 @default.
• W2168430775 hasAuthorship W2168430775A5009328791 @default.
• W2168430775 hasAuthorship W2168430775A5014061069 @default.
• W2168430775 hasAuthorship W2168430775A5034430614 @default.
• W2168430775 hasAuthorship W2168430775A5039841256 @default.
• W2168430775 hasAuthorship W2168430775A5044282595 @default.
• W2168430775 hasAuthorship W2168430775A5046552608 @default.
• W2168430775 hasAuthorship W2168430775A5046584963 @default.
• W2168430775 hasAuthorship W2168430775A5051968927 @default.
• W2168430775 hasAuthorship W2168430775A5063647013 @default.
• W2168430775 hasAuthorship W2168430775A5066102428 @default.
• W2168430775 hasAuthorship W2168430775A5078190224 @default.
• W2168430775 hasBestOaLocation W21684307751 @default.
• W2168430775 hasConcept C111684460 @default.
• W2168430775 hasConcept C126322002 @default.
• W2168430775 hasConcept C142724271 @default.
• W2168430775 hasConcept C150903083 @default.
• W2168430775 hasConcept C203014093 @default.
• W2168430775 hasConcept C207001950 @default.
• W2168430775 hasConcept C2522874641 @default.
• W2168430775 hasConcept C2776914184 @default.
• W2168430775 hasConcept C2777546802 @default.
• W2168430775 hasConcept C2777714996 @default.
• W2168430775 hasConcept C2777914695 @default.
• W2168430775 hasConcept C2779134260 @default.
• W2168430775 hasConcept C2779559532 @default.
• W2168430775 hasConcept C3008058167 @default.
• W2168430775 hasConcept C524204448 @default.
• W2168430775 hasConcept C71924100 @default.
• W2168430775 hasConcept C86803240 @default.
• W2168430775 hasConcept C8891405 @default.
• W2168430775 hasConceptScore W2168430775C111684460 @default.
• W2168430775 hasConceptScore W2168430775C126322002 @default.
• W2168430775 hasConceptScore W2168430775C142724271 @default.
• W2168430775 hasConceptScore W2168430775C150903083 @default.
• W2168430775 hasConceptScore W2168430775C203014093 @default.
• W2168430775 hasConceptScore W2168430775C207001950 @default.
• W2168430775 hasConceptScore W2168430775C2522874641 @default.
• W2168430775 hasConceptScore W2168430775C2776914184 @default.
• W2168430775 hasConceptScore W2168430775C2777546802 @default.
• W2168430775 hasConceptScore W2168430775C2777714996 @default.
• W2168430775 hasConceptScore W2168430775C2777914695 @default.
• W2168430775 hasConceptScore W2168430775C2779134260 @default.
• W2168430775 hasConceptScore W2168430775C2779559532 @default.
• W2168430775 hasConceptScore W2168430775C3008058167 @default.

• next