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• W2168436327 abstract "IL-2 controls the survival of regulatory T cells (Tregs), but it is unclear whether IL-2 also directly affects Treg suppressive capacity in vivo. We have found that eliminating Bim-dependent apoptosis in IL-2- and CD25-deficient mice restored Treg numbers but failed to cure their lethal autoimmune disease, demonstrating that IL-2-dependent survival and suppressive activity can be uncoupled in Tregs. Treatment with IL-2-anti-IL-2-Ab complexes enhanced the numbers and suppressive capacity of IL-2-deprived Tregs with striking increases in CD25, CTLA-4, and CD39/CD73 expression. Although cytokine treatment induced these suppressive mechanisms in both IL-2(-/-) and IL-2(-/-)Bim(-/-) mice, it only reversed autoimmune disease in the latter. Our results suggest that successful IL-2 therapy of established autoimmune diseases will require a threshold quantity of Tregs present at the start of treatment and show that the suppressive capacity of Tregs critically depends on IL-2 even when Treg survival is independent of this cytokine." @default.
• W2168436327 created "2016-06-24" @default.
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• W2168436327 date "2010-10-29" @default.
• W2168436327 modified "2023-10-17" @default.
• W2168436327 title "Cutting Edge: Mechanisms of IL-2–Dependent Maintenance of Functional Regulatory T Cells" @default.
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• W2168436327 doi "https://doi.org/10.4049/jimmunol.0903940" @default.
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