FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168445549> ?p ?o ?g. }

• W2168445549 endingPage "186" @default.
• W2168445549 startingPage "173" @default.
• W2168445549 abstract "SGP-l/prosaposin can be secreted or targeted to the lysosomes where it is processed into smaller saposins (A, B, C, and D) required for the hydrolysis of glycosphingolipids. The deficiency of saposins B and C results in variant forms of metachromatic leukodystrophy and Gaucher?s disease, respectively, which are characterized by lysosomal storage of undegraded glycosphingolipids. In the nervous system, prosaposin presents trophic activity. A mouse model was recently developed by creating a null allele in embryonic stem cells through gene targeting to investigate the phenotypic diversity of prosaposin mutations and the involvement of this protein in lysosomal storage diseases, and for the development of therapeutic approaches. Mice homozygous mutants die at the age of 35?40 days and neurological disorders contribute to the early demise of the mutant mice. The male reproductive organs in homozygous mutants show several abnormalities, such as a decrease in testis size with reduced spermiogenesis and an involution of the prostate, seminal vesicles, and epididymis. In these animals, the blood levels of testosterone remain normal. In the prostate of homozygous mutants, only the basal epithelial cells appear to be present, while the secretory cells are absent. These findings suggest that prosaposin may be involved in the development and maintenance of the male reproductive organs, as well as, in cellular differentiation." @default.
• W2168445549 created "2016-06-24" @default.
• W2168445549 creator A5001257039 @default.
• W2168445549 date "2000-01-01" @default.
• W2168445549 modified "2023-10-04" @default.
• W2168445549 title "ROLE OF PROSAPOSIN IN THE MALE REPRODUCTIVE SYSTEM: EFFECT OF PROSAPOSIN INACTIVATION ON THE TESTIS, EPIDIDYMIS, PROSTATE, AND SEMINAL VESICLES" @default.
• W2168445549 cites W1506724492 @default.
• W2168445549 cites W1565920658 @default.
• W2168445549 cites W1604414616 @default.
• W2168445549 cites W1647156299 @default.
• W2168445549 cites W1769454357 @default.
• W2168445549 cites W1969256622 @default.
• W2168445549 cites W1977203893 @default.
• W2168445549 cites W1978378792 @default.
• W2168445549 cites W1981507196 @default.
• W2168445549 cites W1984560166 @default.
• W2168445549 cites W1986392995 @default.
• W2168445549 cites W1989566457 @default.
• W2168445549 cites W2000356560 @default.
• W2168445549 cites W2009316968 @default.
• W2168445549 cites W2009724964 @default.
• W2168445549 cites W2010504637 @default.
• W2168445549 cites W2013464193 @default.
• W2168445549 cites W2013944448 @default.
• W2168445549 cites W2014248100 @default.
• W2168445549 cites W2015126957 @default.
• W2168445549 cites W2017641062 @default.
• W2168445549 cites W2020129150 @default.
• W2168445549 cites W2033666577 @default.
• W2168445549 cites W2037915126 @default.
• W2168445549 cites W2039288110 @default.
• W2168445549 cites W2040026861 @default.
• W2168445549 cites W2040588955 @default.
• W2168445549 cites W2049631250 @default.
• W2168445549 cites W2055043387 @default.
• W2168445549 cites W2064678211 @default.
• W2168445549 cites W2064874874 @default.
• W2168445549 cites W2070782550 @default.
• W2168445549 cites W2070882122 @default.
• W2168445549 cites W2081147243 @default.
• W2168445549 cites W2086588677 @default.
• W2168445549 cites W2088514907 @default.
• W2168445549 cites W2090565001 @default.
• W2168445549 cites W2094336459 @default.
• W2168445549 cites W2101251049 @default.
• W2168445549 cites W2116966882 @default.
• W2168445549 cites W2130898002 @default.
• W2168445549 cites W2139689892 @default.
• W2168445549 cites W2143838650 @default.
• W2168445549 cites W2152517932 @default.
• W2168445549 cites W2156498317 @default.
• W2168445549 cites W2159256868 @default.
• W2168445549 cites W2161400325 @default.
• W2168445549 cites W2167433496 @default.
• W2168445549 cites W2322338818 @default.
• W2168445549 cites W2323372801 @default.
• W2168445549 cites W2328629600 @default.
• W2168445549 cites W2419563257 @default.
• W2168445549 cites W299444643 @default.
• W2168445549 doi "https://doi.org/10.1080/014850100262146" @default.
• W2168445549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10864364" @default.
• W2168445549 hasPublicationYear "2000" @default.
• W2168445549 type Work @default.
• W2168445549 sameAs 2168445549 @default.
• W2168445549 citedByCount "30" @default.
• W2168445549 countsByYear W21684455492012 @default.
• W2168445549 countsByYear W21684455492015 @default.
• W2168445549 countsByYear W21684455492016 @default.
• W2168445549 countsByYear W21684455492017 @default.
• W2168445549 countsByYear W21684455492018 @default.
• W2168445549 countsByYear W21684455492019 @default.
• W2168445549 countsByYear W21684455492020 @default.
• W2168445549 countsByYear W21684455492021 @default.
• W2168445549 countsByYear W21684455492022 @default.
• W2168445549 countsByYear W21684455492023 @default.
• W2168445549 crossrefType "journal-article" @default.
• W2168445549 hasAuthorship W2168445549A5001257039 @default.
• W2168445549 hasConcept C104317684 @default.
• W2168445549 hasConcept C121608353 @default.
• W2168445549 hasConcept C126322002 @default.
• W2168445549 hasConcept C134018914 @default.
• W2168445549 hasConcept C143065580 @default.
• W2168445549 hasConcept C16685009 @default.
• W2168445549 hasConcept C2776235491 @default.
• W2168445549 hasConcept C2781087480 @default.
• W2168445549 hasConcept C2781171107 @default.
• W2168445549 hasConcept C2781254305 @default.
• W2168445549 hasConcept C54355233 @default.
• W2168445549 hasConcept C61705674 @default.
• W2168445549 hasConcept C71924100 @default.
• W2168445549 hasConcept C86803240 @default.
• W2168445549 hasConcept C95444343 @default.
• W2168445549 hasConceptScore W2168445549C104317684 @default.
• W2168445549 hasConceptScore W2168445549C121608353 @default.
• W2168445549 hasConceptScore W2168445549C126322002 @default.
• W2168445549 hasConceptScore W2168445549C134018914 @default.
• W2168445549 hasConceptScore W2168445549C143065580 @default.
• W2168445549 hasConceptScore W2168445549C16685009 @default.

• next