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- W2168448164 abstract "Surface phosophoglycans such as lipophosphoglycan (LPG) or proteophosphoglycan (PPG) and glycosylinositol phospholipids (GIPLs) modulate essential interactions between Leishmania and mammalian macrophages. Phosphoglycan synthesis depends on the Golgi GDP-mannose transporter encoded by LPG2. LPG2-null (lpg2−) Leishmania major cannot establish macrophage infections or induce acute pathology, whereas lpg2− Leishmania mexicana retain virulence. lpg2− Leishmania donovani has been reported to survive poorly in cultured macrophages but in vivo survival has not been explored. Herein we discovered that, similar to lpg2− L. major, lpg2− L. donovani promastigotes exhibited diminished virulence in mice, but persisted at consistently low levels. lpg2− L. donovani promastigotes could not establish infection in macrophages and could not transiently inhibit phagolysosomal fusion. Furthermore, lpg2− promastigotes of L. major, L. donovani and L. mexicana were highly susceptible to complement-mediated lysis. We conclude that phosphoglycan assembly and expression mediated by L. donovani LPG2 are important for promastigote and amastigote virulence, unlike L. mexicana but similar to L. major." @default.
- W2168448164 created "2016-06-24" @default.
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- W2168448164 date "2009-07-01" @default.
- W2168448164 modified "2023-09-27" @default.
- W2168448164 title "Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts" @default.
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- W2168448164 doi "https://doi.org/10.1016/j.exppara.2009.03.014" @default.
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