FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168454329> ?p ?o ?g. }

• W2168454329 endingPage "e1000378" @default.
• W2168454329 startingPage "e1000378" @default.
• W2168454329 abstract "Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD) and periodontitis. Both diseases are associated with similar risk factors and are characterized by a chronic inflammatory process. In a candidate-gene association study, we identify an association of a genetic susceptibility locus shared by both diseases. We confirm the known association of two neighboring linkage disequilibrium regions on human chromosome 9p21.3 with CHD and show the additional strong association of these loci with the risk of aggressive periodontitis. For the lead SNP of the main associated linkage disequilibrium region, rs1333048, the odds ratio of the autosomal-recessive mode of inheritance is 1.99 (95% confidence interval 1.33–2.94; P = 6.9×10−4) for generalized aggressive periodontitis, and 1.72 (1.06–2.76; P = 2.6×10−2) for localized aggressive periodontitis. The two associated linkage disequilibrium regions map to the sequence of the large antisense noncoding RNA ANRIL, which partly overlaps regulatory and coding sequences of CDKN2A/CDKN2B. A closely located diabetes-associated variant was independent of the CHD and periodontitis risk haplotypes. Our study demonstrates that CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases." @default.
• W2168454329 created "2016-06-24" @default.
• W2168454329 creator A5001476429 @default.
• W2168454329 creator A5007594146 @default.
• W2168454329 creator A5022188479 @default.
• W2168454329 creator A5031706417 @default.
• W2168454329 creator A5040917387 @default.
• W2168454329 creator A5042569584 @default.
• W2168454329 creator A5043565763 @default.
• W2168454329 creator A5059435501 @default.
• W2168454329 creator A5063557940 @default.
• W2168454329 date "2009-02-13" @default.
• W2168454329 modified "2023-10-16" @default.
• W2168454329 title "Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis" @default.
• W2168454329 cites W1499959019 @default.
• W2168454329 cites W1525531948 @default.
• W2168454329 cites W1944558458 @default.
• W2168454329 cites W1964291828 @default.
• W2168454329 cites W1976841572 @default.
• W2168454329 cites W1981168111 @default.
• W2168454329 cites W1991403773 @default.
• W2168454329 cites W2001492139 @default.
• W2168454329 cites W2001913879 @default.
• W2168454329 cites W2014779881 @default.
• W2168454329 cites W2024507597 @default.
• W2168454329 cites W2027139308 @default.
• W2168454329 cites W2030069564 @default.
• W2168454329 cites W2033431538 @default.
• W2168454329 cites W2036198235 @default.
• W2168454329 cites W2043712928 @default.
• W2168454329 cites W2048755332 @default.
• W2168454329 cites W2054955743 @default.
• W2168454329 cites W2058401000 @default.
• W2168454329 cites W2066411968 @default.
• W2168454329 cites W2070454905 @default.
• W2168454329 cites W2072141830 @default.
• W2168454329 cites W2076072304 @default.
• W2168454329 cites W2082122713 @default.
• W2168454329 cites W2091126023 @default.
• W2168454329 cites W2096188298 @default.
• W2168454329 cites W2099817964 @default.
• W2168454329 cites W2100812189 @default.
• W2168454329 cites W2105886563 @default.
• W2168454329 cites W2115830594 @default.
• W2168454329 cites W2120451046 @default.
• W2168454329 cites W2124050695 @default.
• W2168454329 cites W2133707909 @default.
• W2168454329 cites W2134368004 @default.
• W2168454329 cites W2134662886 @default.
• W2168454329 cites W2134738076 @default.
• W2168454329 cites W2134783591 @default.
• W2168454329 cites W2141607524 @default.
• W2168454329 cites W2144062486 @default.
• W2168454329 cites W2144911879 @default.
• W2168454329 cites W2149574088 @default.
• W2168454329 cites W2153111398 @default.
• W2168454329 cites W2159087408 @default.
• W2168454329 cites W2161633633 @default.
• W2168454329 cites W2162530578 @default.
• W2168454329 cites W2163217260 @default.
• W2168454329 cites W2165999166 @default.
• W2168454329 cites W2166967068 @default.
• W2168454329 cites W2170273325 @default.
• W2168454329 cites W2281100215 @default.
• W2168454329 cites W2296936391 @default.
• W2168454329 cites W2491061016 @default.
• W2168454329 cites W4210956735 @default.
• W2168454329 doi "https://doi.org/10.1371/journal.pgen.1000378" @default.
• W2168454329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2632758" @default.
• W2168454329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19214202" @default.
• W2168454329 hasPublicationYear "2009" @default.
• W2168454329 type Work @default.
• W2168454329 sameAs 2168454329 @default.
• W2168454329 citedByCount "196" @default.
• W2168454329 countsByYear W21684543292012 @default.
• W2168454329 countsByYear W21684543292013 @default.
• W2168454329 countsByYear W21684543292014 @default.
• W2168454329 countsByYear W21684543292015 @default.
• W2168454329 countsByYear W21684543292016 @default.
• W2168454329 countsByYear W21684543292017 @default.
• W2168454329 countsByYear W21684543292018 @default.
• W2168454329 countsByYear W21684543292019 @default.
• W2168454329 countsByYear W21684543292020 @default.
• W2168454329 countsByYear W21684543292021 @default.
• W2168454329 countsByYear W21684543292022 @default.
• W2168454329 countsByYear W21684543292023 @default.
• W2168454329 crossrefType "journal-article" @default.
• W2168454329 hasAuthorship W2168454329A5001476429 @default.
• W2168454329 hasAuthorship W2168454329A5007594146 @default.
• W2168454329 hasAuthorship W2168454329A5022188479 @default.
• W2168454329 hasAuthorship W2168454329A5031706417 @default.
• W2168454329 hasAuthorship W2168454329A5040917387 @default.
• W2168454329 hasAuthorship W2168454329A5042569584 @default.
• W2168454329 hasAuthorship W2168454329A5043565763 @default.
• W2168454329 hasAuthorship W2168454329A5059435501 @default.
• W2168454329 hasAuthorship W2168454329A5063557940 @default.
• W2168454329 hasBestOaLocation W21684543291 @default.
• W2168454329 hasConcept C104317684 @default.

• next