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• W2168454611 abstract "The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates the activation of the Raf/MEK/extracellular signal-regulated kinase (ERK) signal transduction pathway. KSR1 disruption in mouse embryo fibroblasts (MEFs) abrogates growth factor-induced ERK activation, H-RasV12-induced replicative senescence, and H-RasV12-induced transformation. Caveolin-1 has been primarily described as a major component of the coating structure of caveolae, which can serve as a lipid binding adaptor protein and coordinates the assembly of Ras, Raf, MEK, and ERK. In this study, we show that KSR1 interacts with caveolin-1 and is responsible for MEK and ERK redistribution to caveolin-1-rich fractions. The interaction between KSR1 and caveolin-1 is essential for optimal activation of ERK as a KSR1 mutant unable to interact with caveolin-1 does not efficiently mediate growth factor-induced ERK activation at the early stages of pathway activation. Furthermore, abolishing the KSR1–caveolin-1 interaction increases growth factor demands to promote H-RasV12-induced proliferation and has adverse effects on H-RasV12-induced cellular senescence and transformation. These data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras." @default.
• W2168454611 created "2016-06-24" @default.
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• W2168454611 creator A5086847901 @default.
• W2168454611 date "2014-09-01" @default.
• W2168454611 modified "2023-10-15" @default.
• W2168454611 title "Caveolin-1 Is Required for Kinase Suppressor of Ras 1 (KSR1)-Mediated Extracellular Signal-Regulated Kinase 1/2 Activation, H-Ras^V12-Induced Senescence, and Transformation" @default.
• W2168454611 cites W1531836615 @default.
• W2168454611 cites W1549194476 @default.
• W2168454611 cites W1966453709 @default.
• W2168454611 cites W1974162922 @default.
• W2168454611 cites W1978535713 @default.
• W2168454611 cites W1979514203 @default.
• W2168454611 cites W1980492226 @default.
• W2168454611 cites W1980529374 @default.
• W2168454611 cites W1982071275 @default.
• W2168454611 cites W1985309852 @default.
• W2168454611 cites W1986372359 @default.
• W2168454611 cites W1986812906 @default.
• W2168454611 cites W1988475719 @default.
• W2168454611 cites W1989261260 @default.
• W2168454611 cites W1991419403 @default.
• W2168454611 cites W1991807950 @default.
• W2168454611 cites W1995150314 @default.
• W2168454611 cites W1998412189 @default.
• W2168454611 cites W1998749643 @default.
• W2168454611 cites W2011184275 @default.
• W2168454611 cites W2019233970 @default.
• W2168454611 cites W2022228445 @default.
• W2168454611 cites W2025941517 @default.
• W2168454611 cites W2030102642 @default.
• W2168454611 cites W2030727312 @default.
• W2168454611 cites W2033382599 @default.
• W2168454611 cites W2036372337 @default.
• W2168454611 cites W2046053482 @default.
• W2168454611 cites W2046774437 @default.
• W2168454611 cites W2049513608 @default.
• W2168454611 cites W2052122921 @default.
• W2168454611 cites W2053100392 @default.
• W2168454611 cites W2057724921 @default.
• W2168454611 cites W2060416249 @default.
• W2168454611 cites W2060840912 @default.
• W2168454611 cites W2061656219 @default.
• W2168454611 cites W2063283353 @default.
• W2168454611 cites W2071718732 @default.
• W2168454611 cites W2073325321 @default.
• W2168454611 cites W2074753255 @default.
• W2168454611 cites W2075796682 @default.
• W2168454611 cites W2079618910 @default.
• W2168454611 cites W2083358105 @default.
• W2168454611 cites W2087404852 @default.
• W2168454611 cites W2088921555 @default.
• W2168454611 cites W2092437783 @default.
• W2168454611 cites W2094222567 @default.
• W2168454611 cites W2095480781 @default.
• W2168454611 cites W2096480261 @default.
• W2168454611 cites W2098573045 @default.
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• W2168454611 cites W2112879240 @default.
• W2168454611 cites W2114287704 @default.
• W2168454611 cites W2116669977 @default.
• W2168454611 cites W2117181640 @default.
• W2168454611 cites W2125547572 @default.
• W2168454611 cites W2126577131 @default.
• W2168454611 cites W2128963767 @default.
• W2168454611 cites W2135730738 @default.
• W2168454611 cites W2138217548 @default.
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• W2168454611 doi "https://doi.org/10.1128/mcb.01633-13" @default.
• W2168454611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4135613" @default.
• W2168454611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25002533" @default.
• W2168454611 hasPublicationYear "2014" @default.
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