Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168459196> ?p ?o ?g. }
- W2168459196 endingPage "51031" @default.
- W2168459196 startingPage "51022" @default.
- W2168459196 abstract "Polyethylene glycol (PEG) has been heavily used as a building block in the design of stealth nanocarriers for drug delivery. Besides allowing a PEGylated particle to avoid opsonization by serum proteins, the shielding effect of grafted PEG molecules suppresses the nanoparticle (NP)-induced bending of the biomembrane. In this study, we investigated the influence of the chain length (molecular weight) of PEG molecules on the interaction between a PEGylated NP and the biomembrane, via coarse grained molecular dynamics simulations. The shielding effect of PEG molecules is affected by several factors, including the dynamics of PEG molecules attaching to the membrane, the conformational transition of these long chains and the improved surface elasticity of a PEGylated NP. Analysis of the structural variations and dynamic behavior of grafted PEG molecules indicates that the polymer chain length is a critical factor in improving the blocking characteristics of a PEGylated NP. In addition, the size of a NP also has an important influence, which should not be neglected in the design of stealth PEGylated nanocarriers. These findings are consistent with experimental results, and to some extent give a molecular level interpretation of some macro-scale observations of the prolonged circulation half-life of stealth nanocarriers." @default.
- W2168459196 created "2016-06-24" @default.
- W2168459196 creator A5063077634 @default.
- W2168459196 creator A5064842058 @default.
- W2168459196 date "2014-10-02" @default.
- W2168459196 modified "2023-09-27" @default.
- W2168459196 title "Computational investigation of the influence of chain length on the shielding effect of PEGylated nanoparticles" @default.
- W2168459196 cites W1966078827 @default.
- W2168459196 cites W1976060195 @default.
- W2168459196 cites W1984233626 @default.
- W2168459196 cites W1987888610 @default.
- W2168459196 cites W1990796256 @default.
- W2168459196 cites W1993147241 @default.
- W2168459196 cites W2002528172 @default.
- W2168459196 cites W2015497529 @default.
- W2168459196 cites W2023888329 @default.
- W2168459196 cites W2029667189 @default.
- W2168459196 cites W2031378691 @default.
- W2168459196 cites W2032654453 @default.
- W2168459196 cites W2035266068 @default.
- W2168459196 cites W2035500672 @default.
- W2168459196 cites W2049286183 @default.
- W2168459196 cites W2054847598 @default.
- W2168459196 cites W2066966994 @default.
- W2168459196 cites W2070166910 @default.
- W2168459196 cites W2072167784 @default.
- W2168459196 cites W2073956487 @default.
- W2168459196 cites W2080008975 @default.
- W2168459196 cites W2080832637 @default.
- W2168459196 cites W2081724315 @default.
- W2168459196 cites W2087217609 @default.
- W2168459196 cites W2101312385 @default.
- W2168459196 cites W2104372415 @default.
- W2168459196 cites W2105897419 @default.
- W2168459196 cites W2119267663 @default.
- W2168459196 cites W2141540858 @default.
- W2168459196 cites W2158148873 @default.
- W2168459196 cites W2161946327 @default.
- W2168459196 cites W2314289749 @default.
- W2168459196 cites W2328064570 @default.
- W2168459196 cites W3101558973 @default.
- W2168459196 doi "https://doi.org/10.1039/c4ra11142g" @default.
- W2168459196 hasPublicationYear "2014" @default.
- W2168459196 type Work @default.
- W2168459196 sameAs 2168459196 @default.
- W2168459196 citedByCount "16" @default.
- W2168459196 countsByYear W21684591962015 @default.
- W2168459196 countsByYear W21684591962017 @default.
- W2168459196 countsByYear W21684591962018 @default.
- W2168459196 countsByYear W21684591962019 @default.
- W2168459196 countsByYear W21684591962020 @default.
- W2168459196 countsByYear W21684591962021 @default.
- W2168459196 countsByYear W21684591962023 @default.
- W2168459196 crossrefType "journal-article" @default.
- W2168459196 hasAuthorship W2168459196A5063077634 @default.
- W2168459196 hasAuthorship W2168459196A5064842058 @default.
- W2168459196 hasConcept C10138342 @default.
- W2168459196 hasConcept C12554922 @default.
- W2168459196 hasConcept C147597530 @default.
- W2168459196 hasConcept C155672457 @default.
- W2168459196 hasConcept C162324750 @default.
- W2168459196 hasConcept C171250308 @default.
- W2168459196 hasConcept C178790620 @default.
- W2168459196 hasConcept C18150654 @default.
- W2168459196 hasConcept C185592680 @default.
- W2168459196 hasConcept C192562407 @default.
- W2168459196 hasConcept C2776964284 @default.
- W2168459196 hasConcept C2779149719 @default.
- W2168459196 hasConcept C2779820397 @default.
- W2168459196 hasConcept C32909587 @default.
- W2168459196 hasConcept C521977710 @default.
- W2168459196 hasConcept C54400483 @default.
- W2168459196 hasConcept C59593255 @default.
- W2168459196 hasConcept C86803240 @default.
- W2168459196 hasConceptScore W2168459196C10138342 @default.
- W2168459196 hasConceptScore W2168459196C12554922 @default.
- W2168459196 hasConceptScore W2168459196C147597530 @default.
- W2168459196 hasConceptScore W2168459196C155672457 @default.
- W2168459196 hasConceptScore W2168459196C162324750 @default.
- W2168459196 hasConceptScore W2168459196C171250308 @default.
- W2168459196 hasConceptScore W2168459196C178790620 @default.
- W2168459196 hasConceptScore W2168459196C18150654 @default.
- W2168459196 hasConceptScore W2168459196C185592680 @default.
- W2168459196 hasConceptScore W2168459196C192562407 @default.
- W2168459196 hasConceptScore W2168459196C2776964284 @default.
- W2168459196 hasConceptScore W2168459196C2779149719 @default.
- W2168459196 hasConceptScore W2168459196C2779820397 @default.
- W2168459196 hasConceptScore W2168459196C32909587 @default.
- W2168459196 hasConceptScore W2168459196C521977710 @default.
- W2168459196 hasConceptScore W2168459196C54400483 @default.
- W2168459196 hasConceptScore W2168459196C59593255 @default.
- W2168459196 hasConceptScore W2168459196C86803240 @default.
- W2168459196 hasFunder F4320321001 @default.
- W2168459196 hasIssue "92" @default.
- W2168459196 hasLocation W21684591961 @default.
- W2168459196 hasOpenAccess W2168459196 @default.
- W2168459196 hasPrimaryLocation W21684591961 @default.
- W2168459196 hasRelatedWork W2342770640 @default.